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IQ4I Research & Consultancy Published new report on Next Generation Sequencing (NGS) Global Market -Sample

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IQ4I Estimates The global NGS market to reach $4.89 billion by 2020. The first report to cover both Market size ($$) and Market Volume (Number of platforms, Number of research labs/hospitals/biotech and Number of Samples per technology)

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IQ4I Research & Consultancy Published new report on Next Generation Sequencing (NGS) Global Market -Sample

  1. 1. 2014 IQ4I Research & Consultancy Pvt. Ltd. info@iq4i.com www.iq4i.com Next Generation Sequencing Global Market – Forecast to 2020 Copyright © 2014 IQ4I All Rights Reserved. This document contains highly confidential information and is the sole property of IQ4I. No part of it may be circulated, copied, quoted, or otherwise reproduced without the approval of IQ4I. [Products (Instruments & Consumables, Services and Work Flow Products), Technology (Targeted Resequencing, Whole Exome Sequencing, RNA Sequencing, Whole Genome Sequencing, ChiP sequencing, De novo sequencing, and Methyl Sequencing), End Users (Academic Research, Hospitals & Clinics, Biotech/Pharma and Others) Applications {Clinical (Oncology, Genetic Screening, Infectious Diseases and Others), Non-Clinical (Oncology, Genetic Screening, Infectious Diseases, Drug & Biomarker discovery, Epidemology, Agriculture and Others)}, Region (North America, Europe, APAC and RoW)],
  2. 2. IQ4I Research & Consultancy Pvt. Ltd. Page 2 Next Generation Sequencing Global Market –Forecast to 2020
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  14. 14. IQ4I Research & Consultancy Pvt. Ltd. Page 14 Next Generation Sequencing Global Market –Forecast to 2020 1.1 REPORT DESCRIPTION Next generation sequencing market is one of the fastest growing segments in the genomics market with an estimated CAGR of around 21% in the next five years. The research study includes the market assessment of various products, technologies, applications, and end-users. The report is definitely one of its kind, includes the data pertaining to the NGS sample volume market analysis by technology, end-users, and applications. The report also includes the installation base of various NGS platforms across the regions. Market analysis of labs performing NGS across the world segmented by lab type such as small, medium and large core. The major factors such as rapid adoption of this technology by researchers and its usability as a substitute of microarray technology in addition to its higher throughput, increased accuracy, and affordable costs are driving the next generation sequencing market growth. However, factors such as reducing capital expenditure from academic institutions and huge dependability on grants funding from the government are hampering the next generation sequencing market growth. In addition, the analysis of large amount of data generated by sequencers, and data storage and management is posing a major challenge. The growth opportunities of this market include cloud computing, rising demand for pre-sequencing, developments in NGS fully integrated instruments and rising nanopore sequencing technology. There is a huge opportunity for this technology in the field of drug discovery, personalized medicine, agricultural and animal research. Among the technology market targeted re-sequencing accounted for the largest share in 2013. The fastest growing technology is whole genome sequencing which has the highest CAGR of more than 25% during the forecast period. In the end users segment academic research holds the largest share in 2013. The fastest growing segment is hospitals and clinics during the forecast period. The highest CAGR is due to rising collaborations among hospitals, research institutes and NGS manufacturers leading to immediate transformation of NGS into applications. The North American region accounts for the largest share of the next generation sequencing market. The European and Asian markets are also expected to grow due to the favorable funding from the government to adopt this technology. The major factors contributing to this market growth include rising adoption by new customers, rising adoption of high-throughput sequencing platforms by government organizations such as Biotechnology and Biological
  15. 15. IQ4I Research & Consultancy Pvt. Ltd. Page 15 Next Generation Sequencing Global Market –Forecast to 2020 Sciences Research Council (BBSRC) (U.K.) and NHGRI (National Human Genome Research Institute) (U.S.). The key players dominating in the next generation sequencing market include Illumina Inc. (U.S.), Life Technologies Corporation (U.S.), Roche Holding AG. (Switzerland), Pacific Biosciences of California Inc. (U.S.), Ambry Genetics Corp. (U.S.), Axeq Technologies Inc. (U.S.), Beijing Genomics Institute (China), GeneDx (U.S.), Fluidigm Corp. (U.S.), Foundation Medicine Inc. (U.S.), Good Start Genetics Inc. (U.S.), Helicos BioSciences Corp. (U.S.), Knome Inc. (U.S.), NABsys Inc. (U.S.), Oxford Nanopore Technologies Ltd. (U.K.), Pathogenica Inc. (U.S.), and QIAGEN N.V. (The Netherlands). Among the platforms Illumina accounted for the largest market share in 2013. Some of the most widely used platforms for NGS sequencing are Roche/454 Life Technologies (Pyrosequencing), the Illumina/Solexa Genome Analyzer (Sequencing by synthesis) the Applied Biosystems SOLiD System (sequencing by ligation), the Helicos, Heliscope (single molecule sequencing) and Pacific Biosciences SMRT (single molecule real time sequencing). Whole genome sequencing, targeted re-sequencing, de novo sequencing, RNA-Seq, ChIP-Seq and methyl-Seq are the major applications that use NGS data analysis tools and services. The report provides an in depth market analysis of the above mentioned segments across the following regions:  North America  Europe  Asia-Pacific  Rest of the World (RoW)
  16. 16. IQ4I Research & Consultancy Pvt. Ltd. Page 16 Next Generation Sequencing Global Market –Forecast to 2020 FIGURE 1 NGS PLATFORM INSTALLATION BASE (2013) Source: National Human Genome Research Institute (NHGRI), National Centre for Genomic Resources (NCGR), Genome Science Centre (GSC), Association of Clinical Research Professionals (ACRP), American Genetic Association (AGA), ASGT, NRCGEB, WHO, and Industry Expert Interviews XX% XX% XX% XX% XX% XX% XX% XX% XX% Thermofisher ScientificRoche 454Pacific BiosciencesPolonator-Dover systemsOther PlatformsIlluminaMiSeqHiSeq 2000Genome Analyser
  17. 17. IQ4I Research & Consultancy Pvt. Ltd. Page 17 Next Generation Sequencing Global Market –Forecast to 2020 TABLE 1 GLOBAL NGS SAMPLES MARKET VOLUME, BY PLATFORM, (2012-2020) (NO’S) Platform 2012 2013 2014 2020 CAGR % (2014-2020) Illumina XX XX 1,810,608 XX XX Thermofisher Scientific XX XX XX XX XX Roche XX XX XX XX 40.0 Pacific Biosciences XX XX XX XX XX Polonator -Dover systems 1,328 XX XX XX XX Others XX XX XX 1,291,254 XX Total XX XX XX XX XX Source: National Human Genome Research Institute (NHGRI), National Centre for Genomic Resources (NCGR), Genome Science Centre (GSC), Association of Clinical Research Professionals (ACRP), American Genetic Association (AGA), ASGT, NRCGEB, WHO, and Industry Expert Interviews Illumina commanded the largest share of XX% of the global next generation sequencing samples market. It accounted for XX samples in 2013 growing at a CAGR of XX% from 2014 to 2020. Other platforms are expected to grow at the highest CAGR of XX% during the forecast period.
  18. 18. IQ4I Research & Consultancy Pvt. Ltd. Page 18 Next Generation Sequencing Global Market –Forecast to 2020 FIGURE 2 NGS TECHNOLOGY MARKET SCENARIO, (2013 - 2020) Source: National Human Genome Research Institute (NHGRI), National Centre for Genomic Resources (NCGR), Genome Science Centre (GSC), Association of Clinical Research Professionals (ACRP), American Genetic Association (AGA), ASGT, NRCGEB, WHO, and Industry Expert Interviews Targeted SequencingRNA SequencingWhole Exome SequencingWhole Genome SequencingChiP SequencingDe novo SequencingMethyl Sequencing0% 5% 10% 15% 20% 25% 30% 0%3%6%9%12%15%18%21%24%27%30% CAGR % (2014 -2020) Market Share % (2013)
  19. 19. IQ4I Research & Consultancy Pvt. Ltd. Page 19 Next Generation Sequencing Global Market –Forecast to 2020 TABLE 2 GLOBAL WHOLE GENOME SEQUENCING MARKET REVENUE, BY REGION, (2012-2020) ($MN) Region 2012 2013 2014 2020 CAGR % (2014-2020) North America XX XX XX 360.2 XX Europe XX XX XX XX XX Asia-Pacific XX XX XX XX XX RoW XX XX XX XX 22.1 Total 126.9 XX XX XX XX Source: National Human Genome Research Institute (NHGRI), National Centre for Genomic Resources (NCGR), Genome Science Centre (GSC), Association of Clinical Research Professionals (ACRP), American Genetic Association (AGA), ASGT, NRCGEB, WHO, and Industry Expert Interviews North America accounted for the largest revenue of $XX million of the global whole genome sequencing technology market in 2013. It is expected to grow at a CAGR of XX% from 2014 to 2020 to reach $XX million by 2020. Asia-Pacific is expected to grow at the highest CAGR of XX% during the forecast period.
  20. 20. IQ4I Research & Consultancy Pvt. Ltd. Page 20 Next Generation Sequencing Global Market –Forecast to 2020 TABLE 3 GLOBAL NGS SAMPLES MARKET VOLUME, BY END- USERS/LABORATORIES, (2012-2020) (NO’S) End Users 2012 2013 2014 2020 CAGR % (2014-2020) Academic Research XX XX XX XX XX Hospitals and Clinics XX XX XX XX 37.8 Biotech/Pharmacy XX XX XX 1,250,130 XX Others XX XX XX XX XX Total 1,328,076 XX XX XX XX Source: National Human Genome Research Institute (NHGRI), National Centre for Genomic Resources (NCGR), Genome Science Centre (GSC), Association of Clinical Research Professionals (ACRP), American Genetic Association (AGA), ASGT, NRCGEB, WHO, and Industry Expert Interviews Academic Research commanded the largest share of XX% of the global next generation sequencing samples market. It accounted for XX samples in 2013 growing at a CAGR of XX% from 2014 to 2020. Hospitals and clinics are expected to grow at the highest CAGR of XX% during the forecast period.
  21. 21. IQ4I Research & Consultancy Pvt. Ltd. Page 21 Next Generation Sequencing Global Market –Forecast to 2020 TABLE 4 GLOBAL NGS LABORATORIES MARKET VOLUME, BY TYPE, (2012-2020) (NO'S) Lab Type 2012 2013 2014 2020 CAGR % (2014-2020) Small Core XX XX XX XX XX Medium Core XX XX XX XX 31.7 Large Core 934 XX XX 4,731 XX Total XX XX XX XX XX Source: National Human Genome Research Institute (NHGRI), National Centre for Genomic Resources (NCGR), Genome Science Centre (GSC), Association of Clinical Research Professionals (ACRP), American Genetic Association (AGA), ASGT, NRCGEB, WHO, and Industry Expert Interviews Large core labs commanded for the largest share of XX% accounting for XX labs of the global next generation sequencing laboratories market in 2013. It is expected to grow at a CAGR of XX% from 2014 to 2020 to reach XX labs by 2020. Medium core labs are expected to grow at the highest CAGR of XX% during the forecast period.
  22. 22. IQ4I Research & Consultancy Pvt. Ltd. Page 22 Next Generation Sequencing Global Market –Forecast to 2020 1.1.1 RESEARCH SOURCES TABLE 5 NEXT GENERATION SEQUENCING MARKET: RESEARCH SOURCES Primary Sources Secondary Sources  Supply Side: Top-level Executives, Marketing Managers, Sales Managers, Regional Managers  Demand Side: Hospital Medical Directors, Laboratory Managers, Research Scientists, Principal Scientists, Purchase/Procurement Managers, Laboratory Technicians, Academic Research  Others: Independent Consultants and Freelancers  IQ4I Repository  NGS Company-Specific annual reports, SEC filings, corporate presentations & Press releases  Associations and Groups : World Health Organization (WHO), National Human Genome Research Institute (NHGRI), National Centre for Genomic Resources (NCGR), Genome Science Centre (GSC), ACRP, AGA, ASGT and NRCGEB  Paid Sources : Factiva, OneSource, Hoovers, Bloomberg  Social Networking & Databases: LinkedIn, Melt-Water, Zintro
  23. 23. IQ4I Research & Consultancy Pvt. Ltd. Page 23 Next Generation Sequencing Global Market –Forecast to 2020 1.2 RESEARCH METHODOLOGY FIGURE 3 NEXT GENERATION SEQUENCING MARKET: RESEARCH APPROACH •Bottom-up and Top-down approach •Data triangulation•Qualitative & Quantitative analysis•NGS market segmentation•Market size, CAGR and market trends validation•Market size of sub segments and market shares of major players•Upcoming trends and technological advancements in types, applications and end users•Validation of factors influencing market and regional market shares•Technical information of NGS and components•Strategic insights, financial revenues and competitive intelligence of Key players•Types, end users, and applications of NGS•Market trends and growth scenario of sub markets and parent marketMarket BreakdownPrimary ResearchSecondary Research
  24. 24. IQ4I Research & Consultancy Pvt. Ltd. Page 24 Next Generation Sequencing Global Market –Forecast to 2020 1.2.1 MARKET SIZE ESTIMATION The global Next Generation Sequencing market size, its different segments and sub-segments is analyzed using both top-down and bottom-up approaches. The market size and revenue calculated using research methodology involves primary and secondary research of major players in the market, factors influencing the market, market segmentation and geographical market scenario. Secondary research of major players include the study of their annual and financial reports, press release while primary research involves interviews from the supply side (CEOs, directors, strategic growth managers, international/regional marketing managers, and marketing executives) and the demand side (reference laboratory heads, hospitals, and purchase managers). Primary and secondary sources helped in verification of percentage shares, splits, and breakdowns. This data is consolidated with detailed inputs and presented in this report. FIGURE 4 NEXT GENERATION SEQUENCING MARKET: TOP-DOWN AND BOTTOM-UP APPROACH Global GenomemarketMarket share ofNext Generation Sequencing PlatformsRegional market sharesMarket share of sub Segments/TechnologiesSub segments market size and CAGROverall market size and CAGRMarket share of the playersin the overall NGSMarket and sub marketsTop players Market Revenue in the Genomics Market: Agilent Technologies, Inc.Beijing Genome InstituteBiomatters, Ltd.GenomatixSoftware GmbhIlluminaInc.Life Technologies Corp. Pacific Biosciences of California Inc.QiagenN.VRoche Holding Ltd.Strand Life Sciences Pvt. LtdGlobal Genome Sequencing market
  25. 25. IQ4I Research & Consultancy Pvt. Ltd. Page 25 Next Generation Sequencing Global Market –Forecast to 2020 FIGURE 5 NEXT GENERATION SEQUENCING MARKET: FORECASTING MODEL Historical Data and trends of NGSMarketEvolutionCompany developmentsApplications Download PatternRegulatory LandscapeFactors InfluencingMarket GrowthMarket OpportunitiesAgreements & Joint ventures, New product launchTechnology EvolutionSupply chain trendAdoption patternRegulationsMarket ShareValue and volume analysisGeographical Usage Market PenetrationMarket RestraintsInvestmentsMarket Drivers. Historical Market DataImpact Analysis of Market TrendsMarket Size & Forecast by TechnologyMarket Size & Forecast byApplications& End UsersGlobal NGS Market Size, Segmental share and CAGR from 2014-2020Market Trend and Growth Forecasting
  26. 26. IQ4I Research & Consultancy Pvt. Ltd. Page 26 Next Generation Sequencing Global Market –Forecast to 2020 1.2.2 MARKET BREAKDOWN & DATA TRIANGULATION FIGURE 6 NEXT GENERATION SEQUENCING MARKET: MARKET BREAKDOWN & DATA TRIANGULATION Market share of NGS Market in Global Genomics marketTop-downPrimary ResearchBottom-upSecondary ResearchNGSMarket(~ Bn) (2013) •Financial/Annual reports•Investor Presentations•SEC filings•Scientific Journals•Organizations/ Associations & GroupsMarket Share analysis of key playersDemand & Supply side: Laboratories, Research institutes, Healthcare InstitutionsExecutives from major companies, Consultants
  27. 27. IQ4I Research & Consultancy Pvt. Ltd. Page 27 Next Generation Sequencing Global Market –Forecast to 2020 Disclaimer: IQ4I strategic analysis services are limited publications containing valuable market information provided to a select group of customers in response to orders. Our customers acknowledge, when ordering, that IQ4I strategic analysis services are for our customers’ internal use and not for general publication or disclosure to third parties. Quantitative market information is based primarily on interviews and therefore, is subject to fluctuation. IQ4I does not endorse any vendor, product or service depicted in its research publications. IQ4I strategic analysis publications consist of the opinions of IQ4I' research and should not be construed as statements of fact. IQ4I disclaims all warranties, expressed or implied, with respect to this research, including any warranties of merchantability or fitness for a particular purpose. IQ4I takes no responsibility for any incorrect information supplied to us by manufacturers or users. All trademarks, copyrights and other forms of intellectual property belong to their respective owners and may be protected by copyright. Under no circumstance may any of these be reproduced in any form without the prior written agreement of their owner. No part of this strategic analysis service may be given, lent, resold or disclosed to non- customers without written permission. Reproduction and/or transmission in any form and by any means including photocopying, mechanical, electronic, recording or otherwise, without the permission of the publisher is prohibited. For information regarding permission, contact: Tel: +91 80 60500229 Email: satish.birudukota@IQ4I.com

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