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Vaccination in pregnancy: Safety and Boosters

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Vaccination in pregnancy: Safety and Boosters

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Webinar: Demystifying COVID-19 Vaccine Booster
Vaccination in pregnancy : Safety and Boosters
Speaker: Dr. Muniswaran Ganeshan

More information, please visit: https://clinupcovid.mailerpage.com/resources/r1r5o3-demystifying-covid-19-vaccine-boo

Webinar: Demystifying COVID-19 Vaccine Booster
Vaccination in pregnancy : Safety and Boosters
Speaker: Dr. Muniswaran Ganeshan

More information, please visit: https://clinupcovid.mailerpage.com/resources/r1r5o3-demystifying-covid-19-vaccine-boo

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Vaccination in pregnancy: Safety and Boosters

  1. 1. Safety of COVID-19 Vaccination & Boosters in Pregnancy Dr. Muniswaran Ganeshan Maternal Fetal Medicine Consultant, Women and Children’s Kuala Lumpur Hospital
  2. 2. No conflict of interest • This slide was prepared for the Webinar Demystifying the COVID-19 Vaccine Booster on 8th Dec 2021, by Dr. Muniswaran Ganeshan, Maternal Fetal Medicine Consultant, Women and Children’s Kuala Lumpur Hospital, Malaysia. •This is intended to share within healthcare professionals, not for public. •Kindly acknowledge “Clinical Updates in COVID-19 http://www.nih.gov.my/covid-19” should you plan to share the information obtained from this slide with your colleagues.
  3. 3. COVID 19 & Pregnancy Vaccination in pregnancy Safety & Booster
  4. 4. COVID-19 & pregnancy
  5. 5. What has history thought us about infections in pregnancy?
  6. 6. MALAYSIAN MMR (2000 – 2018)
  7. 7. COVID 19 statistics (31st November 2021) US 148,327 screened positive 241 deaths 0.016% UK 3371 symptomatic 14 deaths 0.4% Malaysia 14,491 screened positive 184 deaths 1.27%
  8. 8. Living systematic review Covid-19 pregnant vs non pregnant women Mortality ICU admissions Stillbirth Neonatal death NICU admissions Fetal distress C O V I D Mothers
  9. 9. Systematic reviews & pregnancy outcomes Oxygen support Mechanical ventilation Caesarean section Preterm delivery Fetal distress C O V I D Mothers
  10. 10. First or Second wave?
  11. 11. First or Second wave? 1 in 10 alpha variant 1 in 7 delta variant
  12. 12. Other publications
  13. 13. Other publications
  14. 14. Malaysian COVID-19 CEMD
  15. 15. Timing of maternal deaths 66% of them required delivery
  16. 16. Maternal deaths – BMI & Co-morbidities
  17. 17. Maternal Deaths & Age
  18. 18. COVID 19 & Pregnancy Pregnant mothers are vulnerable 1 in 7 mothers needed ICU admissions Risk of ventilation & death is increased in pregnancy Fetal risk Preterm, stillbirth, neonatal death, caesarean section Risk of transmission to fetus – 1-2%
  19. 19. Vaccination in pregnancy
  20. 20. The Malaysian Experience Medical & non medical frontlines (Pregnant & Breastfeeding) February – April 2021 High risk pregnancies April- August 2021 All pregnant mothers August 2021 Booster All pregnant mothers
  21. 21. V safe pregnancy registry US Total vaccinated 177,736 Enrolled 6,685
  22. 22. V safe pregnancy registry US Total vaccinated 177,736 Enrolled 6,685 Malaysia 176,761 till 30th November 2021
  23. 23. Effectivenes s
  24. 24. Vaccination & Maternal deaths 66.7 % had Sinovac Total vaccinated pregnant mothers : 176,761
  25. 25. Is it safe?
  26. 26. Safety of mRNA vaccinations in the first trimester
  27. 27. Other vaccines?
  28. 28. Other vaccines?
  29. 29. Fetal benefits?
  30. 30. Booster or no booster in pregnancy?
  31. 31. •Prevent symptomatic infection (11-206) •To prevent severe infections – 412-2058 •To prevent preterm delivery 200 •To prevent caesarean section - 182
  32. 32. •Prevent symptomatic infection (11-206) •To prevent severe infections – 412-2058 •To prevent preterm delivery 200 •To prevent caesarean section - 182
  33. 33. Other guidelines
  34. 34. Summary Fear COVID-19, not the vaccine No evidence does not mean it is unsafe Appreciate physiological adaptations in pregnancy Science of probability mRNA vaccines are safe Be holistic, not fetal centric
  35. 35. Women don’t die because of illness that we cannot treat. They die because society still hasn’t decided that their lives are worth saving Prof Mahmoud Fathalla
  36. 36. THANK YOU www.obstetricmedicine.my

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