“Knowledge Management in       Biomedical Translational             Research”                          HIKM-ACW           ...
Outline• Biomedical translational research• The role of knowledge management• HBIR@UniMelb
BiomedicalTranslational Research
---The ultimate goal of translationalmedicine is the development of newtreatments and insights towards theimprovement of h...
USA: 7 NCBC + 60 CTSA + 1 new NCATS  www.ScienceTranslationalMedicine.org             6 July 2011 Vol 3 Issue 90
Transdisciplinary paths – research teams                                   Bench (Bioscientist)                           ...
Biomedical Informatics: Biomedical Information                                                  processing from particle t...
The role of Knowledgemanagement
The role of knowledge management to                    facilitate translational research•  Update researchers and clinicia...
SPECTRUM OF BIOMEDICAL KNOWLEDGE IN INTERNET               Maths     Physics   Chemistry    Biology    Medicine   Engineer...
- Knowledge management - BIKMAS
Knowledge management   •  Blogs   •  Journals   •  Podcasts   •  Bookmarks   •  News   •  Slideshare   •  Videos
Questions – Data integration•  What are the main features of the disease?•  Are there any drugs for the disease?•  Are the...
DiseaseCard•  DiseaseCard•  Collaboration with   University of Aveiro•  Integrates information   from 20 reference   datab...
Clinical relevance of biomarkers- Biomarkercard
INTERNET  WEB                                  MEDLINE  2.0                  Imaging                                      ...
Education - Genome Game
HBIR @UniMelb
Model for the new Centre for HBIRAcademichome                                                            Funding          ...
Research•  Three main areas:    –  Informatics - personalized       medicine    –  Informatics - simulation,       modelin...
Education•  Health students and professionals,   Engineers & informaticians•  Experts in the field (Master, PhD in HBI)•  ...
OutreachCollaborative Health Informatics Research Seminar & Social (CHIRSS)Focus on the future of healthcare and new oppor...
Scoop.it
Netvibes
Paper.li
Thank you for your attention!© Copyright The University of Melbourne 2012
HIKM 2012 presentation fjms
HIKM 2012 presentation fjms
HIKM 2012 presentation fjms
HIKM 2012 presentation fjms
HIKM 2012 presentation fjms
HIKM 2012 presentation fjms
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HIKM 2012 presentation fjms

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Presentation given at Health Informatics and Knowledge Management conference
(http://publichealth.curtin.edu.au/HIKM/), as part of Australasian Computer Science Week 2012.
http://www.cs.rmit.edu.au/acsw2012/

Published in: Health & Medicine, Education
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HIKM 2012 presentation fjms

  1. 1. “Knowledge Management in Biomedical Translational Research” HIKM-ACW HIKM ---- 1 Feb 2012 Fernando J. Martin-Sanchez Professor and Chair of Health Informatics Melbourne Medical School Faculty of Medicine, Dentistry & Health Sciences &Director, Health and Biomedical Informatics Research (HBIR) Unit
  2. 2. Outline• Biomedical translational research• The role of knowledge management• HBIR@UniMelb
  3. 3. BiomedicalTranslational Research
  4. 4. ---The ultimate goal of translationalmedicine is the development of newtreatments and insights towards theimprovement of health acrosspopulations.--- Woolf, SH. JAMA 2008
  5. 5. USA: 7 NCBC + 60 CTSA + 1 new NCATS www.ScienceTranslationalMedicine.org 6 July 2011 Vol 3 Issue 90
  6. 6. Transdisciplinary paths – research teams Bench (Bioscientist) Facilitate KNOWLEDGE MANAGEMENTTranslate basic research structured,findings into clinical solutions standardized, WHAT anonymized clinical data Bedside (Clinician) sets for Evaluate the efficacy of research Interventions across communities WHY Population (Epidemiologist) Assess impact on health policies HOW Society at large (Health services researcher)
  7. 7. Biomedical Informatics: Biomedical Information processing from particle to populationMultilevel modeling, ontologies, data integration,data mining, …Altman RB, Balling R, Brinkley JF, Coiera E, Consorti F, Dhansay MA, Geissbuhler A, Hersh W, Kwankam SY, Lorenzi NM, Martin-Sanchez F, Mihalas GI,Shahar Y, Takabayashi K, Wiederhold G. "Commentaries on Informatics and medicine: from molecules to populations". Methods Inf Med. 2008;47(4):296-317.
  8. 8. The role of Knowledgemanagement
  9. 9. The role of knowledge management to facilitate translational research•  Update researchers and clinicians on the latest developments within relevant areas•  Data integration (putting into context molecular information from the patient with existing biomedical knowledge on the web)•  Assess the clinical relevance of biomarkers•  Supporting decision making through new clinical guidelines, and alerting systems which take into account genetic data from patients•  Education of patients and health professionals in genomics and informatics
  10. 10. SPECTRUM OF BIOMEDICAL KNOWLEDGE IN INTERNET Maths Physics Chemistry Biology Medicine Engineering …. BIKMAS SYSTEM RSS feeds (BiomedicalInformationKnowledgeManagement Archive of Antena topics System)‫‏‬ USES (several formats and applications)‫‏‏‬Webs Courses ‫‏‬ News‫ ‏‬Scientific Documents (White Paper, articles)‫‏‬
  11. 11. - Knowledge management - BIKMAS
  12. 12. Knowledge management •  Blogs •  Journals •  Podcasts •  Bookmarks •  News •  Slideshare •  Videos
  13. 13. Questions – Data integration•  What are the main features of the disease?•  Are there any drugs for the disease?•  Are there any gene therapies or clinical trials for the disease?•  What laboratories perform genetic tests for the disease?•  What genes cause the disease?•  On which chromosomes are these genes located?•  What mutations have been found in these genes?•  What names are used to refer to these genes?•  What are the proteins coded by these genes?•  What are the functions of the gene product?•  What is the 3D structure for these proteins?•  What are the enzymes associated to these proteins?
  14. 14. DiseaseCard•  DiseaseCard•  Collaboration with University of Aveiro•  Integrates information from 20 reference databases•  2000+ genetic diseasesDias GS, Oliveira JL, Vicente J, Martin-Sanchez F.“Integrating medical and genomic data: a successfulexample for rare diseases”. Stud. Health Technol. Inform.2006;124:125-30. http://www.diseasecard.org
  15. 15. Clinical relevance of biomarkers- Biomarkercard
  16. 16. INTERNET WEB MEDLINE 2.0 Imaging •  My NCBI•  Blogs •  Pubmed•  Journals•  Podcasts•  Bookmarks•  News•  OMIM•  Genetests Disease•  Uniprot•  dbSNP•  KEGG Biomarkers•  Enzyme•  PDB… Nano - Biotechnology Knowledge Management Biomedical databases
  17. 17. Education - Genome Game
  18. 18. HBIR @UniMelb
  19. 19. Model for the new Centre for HBIRAcademichome Funding Agencies (competitive Grants) Foundational Foundational Contributing Contributing member member Support of specific activities Liaison with medical specialties
  20. 20. Research•  Three main areas: –  Informatics - personalized medicine –  Informatics - simulation, modeling and sensors –  Informatics – e-health•  All of them aim at: –  Improving health services –  Facilitating translational research –  Contributing to professional development
  21. 21. Education•  Health students and professionals, Engineers & informaticians•  Experts in the field (Master, PhD in HBI)•  Undergrad – Bachelor of Biomed, Science•  Postgrad New MD – Across the Curriculum•  MSc - Offer an elective subject: “eHealth and Biomedical Informatics Systems” –  MSc Information Science, MSc Bioinformatics, MSc Biomedical Engineering, MSc Public Health, …•  2nd Elective subject (eHealth and Biomedical Informatics Methods)•  4 subjects stream within an existing MSc•  Master and PhD degrees
  22. 22. OutreachCollaborative Health Informatics Research Seminar & Social (CHIRSS)Focus on the future of healthcare and new opportunities that are emerging for collaborative R&D in Health and Biomedical Informatics.Once a month.CHIRSS is supported by the Institute for a Broadband Enabled Society and Victorian eResearch Strategic InitiativePartnershipsJournal clubA new Health and Biomedical Informatics journal club has started up, with a focus on strategies for publishing health informatics research. We meet from 12.00 to 1.00 on the second Tuesday of the month in the ICT Building, 111 Barry Street, level 4, room 9.Bulletins“Liaisons” with Clinical specialtiesWeb pagehttp://www.healthinformatics.unimelb.edu.au
  23. 23. Scoop.it
  24. 24. Netvibes
  25. 25. Paper.li
  26. 26. Thank you for your attention!© Copyright The University of Melbourne 2012

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