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Offord hartley oxytocine innovation 2014 new

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Les saignements incontrôlés après l’accouchement - A >99% un problème des populations les plus pauvres de la planète
- Oliver Hartley & Robin Offord Faculté de Médecine et
la Fondation Mintaka pour la Recherche Médicale

Published in: Health & Medicine
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Offord hartley oxytocine innovation 2014 new

  1. 1. Les saignements incontrôlés après l’accouchement A >99% un problème des populations les plus pauvres de la planète Oliver Hartley & Robin Offord Faculté de Médecine et la Fondation Mintaka pour la Recherche Médicale .
  2. 2. Les saignements incontrôlés après l'accouchement • Environ 140'000 femmes par an (99% aux pays en développement) meurent de tels saignements. • 1'600’000 femmes survivent mais restent sévèrement anémiques. • Souvent, les victimes ont une charge de famille déjà, tant économique qu’humaine.
  3. 3. 1000
  4. 4. 2000
  5. 5. 3000
  6. 6. 4000
  7. 7. Le traitement de choix marche mal sous les tropiques • L’oxytocine, une substance naturelle, constitue le meilleur médicament • Or, celle-ci résiste mal à la chaleur tropicale • Elle doit être injectée, ce qui limite son utilisation aux établissements médicalisés. • Le misoprostol résiste à la chaleur et peut être administré par voie orale mais il présente de graves inconvénients.
  8. 8. Un prNoboltèrem seomluatilognré elle
  9. 9. Inhalation
  10. 10. Zone Climatique OMS IVb (la plus sévère) 30° C, 75% humidité relative • Brésil, Brunei, Cambodge, Indonésie, Laos, Malaysia, Myanmar, Philippines, Singapore, Thaïlande, Vietnam • Nos essais: 40°C 75% humidité relative • De différentes formulations (divers ions divalents) : MannKind Corporation (USA)
  11. 11. Prochaine étape • Rassembler les données pour le dossier d’autorisation d’essais cliniques de Swissmedic • Planifier et exécuter un essai phase 1 (sureté)
  12. 12. Résultats espérés • Réduction significative dans les ~140’000 décès, 1,6 millions cas de morbidité • Moins d’utilisation de misoprostol • Utilisation thérapeutique et prophylactique au delà du contexte hospitalier
  13. 13. Merci de votre attention Faisons en sorte qu’elle reste en bonne santé! Photo: F. Reuss
  14. 14. Mintaka? Mintaka est le nom que donnent les marins à delta-Orionis, la plus à l’ouest des trois étoiles formant le baudrier d’Orion. C’est la seule étoile brillante qui soit suffisamment près de l'équateur céleste pour être visible de toutes les régions de la Terre, ne favorisant ni l’hémisphère Nord, ni l’hémisphère Sud. Ainsi, son nom symbolise la vision et les objectifs de la Fondation.

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