1
JENIS KOLAGENJENIS KOLAGEN TEMPATTEMPAT SEL-SEL YANGSEL-SEL YANG
DIHASILKANDIHASILKAN
CIRI-CIRICIRI-CIRI
TIPE I (TIPE I ...
2
JENIS KOLAGENJENIS KOLAGEN TEMPATTEMPAT SEL-SEL YANGSEL-SEL YANG
DIHASILKANDIHASILKAN
CIRI-CIRICIRI-CIRI
TIPE III (tersu...
3
In addition, a number of other collagens have been recently identified in the followingIn addition, a number of other co...
4
GAMBARANGAMBARAN KOLAGENKOLAGEN RETIKULERRETIKULER ELASTISELASTIS
JaringanJaringan
molekulermolekuler
Triple-stranded he...
5
GAMBARANGAMBARAN KOLAGENKOLAGEN RETIKULERRETIKULER ELASTISELASTIS
Asam dan basaAsam dan basa
kuatkuat
LarutLarut
Pewarna...
6
JENIS SELJENIS SEL FUNGSI UMUMFUNGSI UMUM
FibroblasFibroblas Menghasilkan serat-serat (kolagen, retikuler, elastin) danM...
7
Reseptor permukaanReseptor permukaan
bagi:bagi:
Receptors that bind C3b component of complementReceptors that bind C3b c...
8
Menghasilkan FagositMenghasilkan Fagosit Sel matiSel mati
Seluler debrisSeluler debris
BakteriBakteri
Pemaparan AntigenP...
9
Menghasilkan sekretMenghasilkan sekret
khususkhusus
Fibroblast growth factor (FGF)Fibroblast growth factor (FGF)
Transfo...
10
NAMA SELNAMA SEL FUNGSIFUNGSI TEMPATTEMPAT
MacrophageMacrophage Fagositosis, antigenFagositosis, antigen
presentationpr...
11
NAMA SELNAMA SEL FUNGSIFUNGSI TEMPATTEMPAT
MicrogliaMicroglia Fagositosis, antigenFagositosis, antigen
presentationpres...
12
HeparinHeparin (acidic GAG)(acidic GAG) Anticoagulant: binds to fibronectin, growthAnticoagulant: binds to fibronectin,...
13
Eosinophil chemotactic factor ofEosinophil chemotactic factor of
anaphilaxis (ECF-A)anaphilaxis (ECF-A)
Attracts eosino...
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Jaringanpenyambung 2

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Jaringanpenyambung 2

  1. 1. 1 JENIS KOLAGENJENIS KOLAGEN TEMPATTEMPAT SEL-SEL YANGSEL-SEL YANG DIHASILKANDIHASILKAN CIRI-CIRICIRI-CIRI TIPE I (TIPE I (~ 90%)~ 90%) (tersusun atas(tersusun atas dua jenis rantai-dua jenis rantai-αα)) Lapisan kulit, tendonLapisan kulit, tendon FibroblasFibroblas Hidroksilisin rendah,Hidroksilisin rendah, karbohidrat rendahkarbohidrat rendah Tersebar (areolar),Tersebar (areolar), memadati jaringanmemadati jaringan penyambung, serat-penyambung, serat- serat kolagenserat kolagen Sel retikular dan ototSel retikular dan otot halushalus Hampir kebanyakanHampir kebanyakan tersebar di organtersebar di organ internainterna TulangTulang OsteoblasOsteoblas Dentin (Gigi)Dentin (Gigi) OdontoblasOdontoblas TIPE II (tersusunTIPE II (tersusun hanya satu jenishanya satu jenis rantai-rantai-αα)) Tulang rawan hialinTulang rawan hialin dan elastindan elastin Lensa mata, jaringanLensa mata, jaringan invertebralinvertebral KondrositKondrosit Sel-sel retinaSel-sel retina KondrositKondrosit Hidroksilisin tinggi,Hidroksilisin tinggi, karbohidrat tinggikarbohidrat tinggi (Fibril lebih tipis dari(Fibril lebih tipis dari tipe I)tipe I) JENIS-JENIS SERAT KOLAGEN
  2. 2. 2 JENIS KOLAGENJENIS KOLAGEN TEMPATTEMPAT SEL-SEL YANGSEL-SEL YANG DIHASILKANDIHASILKAN CIRI-CIRICIRI-CIRI TIPE III (tersusunTIPE III (tersusun hanya atas satuhanya atas satu jenis rantai-jenis rantai-αα)) Menyebar di jaringanMenyebar di jaringan penyambung; serabutpenyambung; serabut retikuler, lapisan kulitretikuler, lapisan kulit papiler (pada fasepapiler (pada fase perkembangan)perkembangan) Fibroblas dan sel-selFibroblas dan sel-sel retikularretikular Hidroksiprolin tinggi,Hidroksiprolin tinggi, hidroksilisin rendah,hidroksilisin rendah, karbohidrat rendahkarbohidrat rendah Pembuluh darahPembuluh darah Sel otot halus, selSel otot halus, sel endotelialendotelial TIPE IV (tersusunTIPE IV (tersusun atas dua jenisatas dua jenis rantai-rantai-αα)) Lamina basalLamina basal Kapsul lensa mataKapsul lensa mata Sel epitelial dan selSel epitelial dan sel endotelialendotelial Epitel lensaEpitel lensa Hidroksilisin sangatHidroksilisin sangat tinggi, karbohidrattinggi, karbohidrat tinggi, (menahantinggi, (menahan prokolagen menjadiprokolagen menjadi peptida)peptida) TIPE VTIPE V Membran fetalMembran fetal (plasenta)(plasenta) Membran lapisanMembran lapisan dasardasar TulangTulang Otot halusOtot halus FibroblasFibroblas Sel-sel epitelialSel-sel epitelial OsteoblasOsteoblas Sel-sel otot halusSel-sel otot halus JENIS-JENIS SERAT KOLAGEN
  3. 3. 3 In addition, a number of other collagens have been recently identified in the followingIn addition, a number of other collagens have been recently identified in the following location:location: TIPE VITIPE VI Short triple helical segment about 100 nm long; occur in small amounts inShort triple helical segment about 100 nm long; occur in small amounts in kidney, liver, and uterus, where type I and III collagens are foundkidney, liver, and uterus, where type I and III collagens are found TIPE VIITIPE VII Basal laminae of many ephiteliaBasal laminae of many ephitelia TIPE VIIITIPE VIII Secretory product of endothelial cells; major component of Decemet’sSecretory product of endothelial cells; major component of Decemet’s membrane in the corneamembrane in the cornea TIPE IXTIPE IX Mainly in cartilage; found with type II collagenMainly in cartilage; found with type II collagen TIPE XTIPE X Confined to cartilage; in matrix surrounding hypertrophic chondrocytesConfined to cartilage; in matrix surrounding hypertrophic chondrocytes TIPE XITIPE XI Associated with type OO collagen in cartilage; function unknownAssociated with type OO collagen in cartilage; function unknown TIPE XIITIPE XII Tendon; properties in common with type IX collagenTendon; properties in common with type IX collagen TIPE XIIITIPE XIII EndotheliumEndothelium TIPE XIVTIPE XIV Fetal skin and tendonFetal skin and tendon Thus far, some 25 distinct collagenThus far, some 25 distinct collagen αα-chains, each encoded by a separate gene, have-chains, each encoded by a separate gene, have been identified.been identified.
  4. 4. 4 GAMBARANGAMBARAN KOLAGENKOLAGEN RETIKULERRETIKULER ELASTISELASTIS JaringanJaringan molekulermolekuler Triple-stranded helix;Triple-stranded helix; Tiap helaiTiap helai ~ 1000 AA;~ 1000 AA; Molekul ~ panjang 300Molekul ~ panjang 300 nm, diameter 1,5 nmnm, diameter 1,5 nm (glisin, hidroksiprolin,(glisin, hidroksiprolin, hidroksilisin)hidroksilisin) Kolagen tipe IIIKolagen tipe III Elastin 830 aminoElastin 830 amino acid residues long;acid residues long; contains desmocine,contains desmocine, isodesmocineisodesmocine (dibentuk dari empat(dibentuk dari empat molekul lisin)molekul lisin) Jaringan FibrilarJaringan Fibrilar Diameter fiber 2-10Diameter fiber 2-10 μμmm (tidak bercabang);(tidak bercabang); diameter fibril ~ 50nm;diameter fibril ~ 50nm; mikrofibril yang lebih kecilmikrofibril yang lebih kecil Diameter fiberDiameter fiber 0,2-20,2-2 μμm, fibril 25-m, fibril 25- 45 nm45 nm Diameter fiber 1-4Diameter fiber 1-4 μμm; cabang fiberm; cabang fiber Tidak ada fibrilTidak ada fibril Diameter mikrofibrilDiameter mikrofibril ~ 12 nm~ 12 nm Axial periodicityAxial periodicity Fibrils 670 A; axialFibrils 670 A; axial periodicityperiodicity 670 A670 A Tidak adaTidak ada Air mendidihAir mendidih Merubah kolagen menjadiMerubah kolagen menjadi gelatingelatin ResistenResisten Asam dan basaAsam dan basa lemahlemah MembengkakMembengkak Sama denganSama dengan kolagenkolagen Resisten terhadapResisten terhadap asam dan basaasam dan basa lemahlemah PERBANDINGAN CIRI-CIRI SERAT JARINGAN PENYAMBUNG
  5. 5. 5 GAMBARANGAMBARAN KOLAGENKOLAGEN RETIKULERRETIKULER ELASTISELASTIS Asam dan basaAsam dan basa kuatkuat LarutLarut PewarnaanPewarnaan Dengan pewarnaanDengan pewarnaan asidofilikasidofilik Silver (argirofilik)Silver (argirofilik) PAS+PAS+ Resorsin fuchsin,Resorsin fuchsin, resorsin orseinresorsin orsein Efek enzimEfek enzim Larut dalam pepsin danLarut dalam pepsin dan kolagenasekolagenase Sensitif terhadapSensitif terhadap elastaseelastase Sel penghasil seratSel penghasil serat FibroblasFibroblas Sel otot halus di pembuluhSel otot halus di pembuluh darahdarah OsteoblasOsteoblas KondroblasKondroblas OdontoblasOdontoblas Kolagen tipe IVKolagen tipe IV Diproduksi oleh selDiproduksi oleh sel epitel dan sel endotelialepitel dan sel endotelial Sel retikulerSel retikuler FibroblasFibroblas Sel Schwan (untukSel Schwan (untuk endoneurium)endoneurium) FibroblasFibroblas Sel otot halus diSel otot halus di pembuluh darahpembuluh darah PERBANDINGAN CIRI-CIRI SERAT JARINGAN PENYAMBUNG
  6. 6. 6 JENIS SELJENIS SEL FUNGSI UMUMFUNGSI UMUM FibroblasFibroblas Menghasilkan serat-serat (kolagen, retikuler, elastin) danMenghasilkan serat-serat (kolagen, retikuler, elastin) dan selaput tak beraturan (glikosaminoglikans, proteglikans)selaput tak beraturan (glikosaminoglikans, proteglikans) MakrofagMakrofag Fagosit (mis: bakteri)Fagosit (mis: bakteri) Pemaparan antigenPemaparan antigen PerisitPerisit Membedakan antara fibroblas, sel retikuler, makrofag, ototMembedakan antara fibroblas, sel retikuler, makrofag, otot halus dalam pembuluh darah, adiposithalus dalam pembuluh darah, adiposit Sel MastSel Mast Secrete heparin, histamine, slow-reacting substanse ofSecrete heparin, histamine, slow-reacting substanse of anaphylaxis, eosinophilic chemotactic factor anaphylaxisanaphylaxis, eosinophilic chemotactic factor anaphylaxis Foreign body giant cellForeign body giant cell Phagocytic (larger particulate material)Phagocytic (larger particulate material) Sel retikulerSel retikuler Memproduksi serat retikuler (kolagen tipe ke-3) untukMemproduksi serat retikuler (kolagen tipe ke-3) untuk pembuluh limf, limpa, sum-sum tulang, dllpembuluh limf, limpa, sum-sum tulang, dll AdipositAdiposit Penimbunan lemak, mobilitasPenimbunan lemak, mobilitas Kondroblas (kondrosit)Kondroblas (kondrosit) Mengeluarkan kolagen atau serat elastis seperti halnyaMengeluarkan kolagen atau serat elastis seperti halnya substansi intersel amorf (glikosaminoglikans, proteoglikans),substansi intersel amorf (glikosaminoglikans, proteoglikans), dan protein lainnyadan protein lainnya OsteoblasOsteoblas Mengeluarkan kolagen, susunan tulang (proteoglikans)Mengeluarkan kolagen, susunan tulang (proteoglikans) JENIS SEL DI JARINGAN PENYAMBUNG
  7. 7. 7 Reseptor permukaanReseptor permukaan bagi:bagi: Receptors that bind C3b component of complementReceptors that bind C3b component of complement Fc receptors, IgGFc receptors, IgG IL-2, IL-1, IL-6IL-2, IL-1, IL-6 Tumor necrosis factor (TFN)Tumor necrosis factor (TFN) (interferon)(interferon) ATPaseATPase 5’-Nucleotidase5’-Nucleotidase Muatan LisosomMuatan Lisosom Hidrolase asamHidrolase asam LisozimLisozim MieloperoksidaseMieloperoksidase Makrofag aktifatorMakrofag aktifator LipopolisakaridaLipopolisakarida Interferon-Interferon-γγ Efek Interleukin yangEfek Interleukin yang dihasilkan olehdihasilkan oleh makrofagmakrofag Mengaktifkan B limfositMengaktifkan B limfosit Faktor kemotaktis untuk neutrofilFaktor kemotaktis untuk neutrofil Meningkatkan sirkulasi neutrofilMeningkatkan sirkulasi neutrofil Bagian dari fibroblasBagian dari fibroblas FUNGSI MAKROFAG
  8. 8. 8 Menghasilkan FagositMenghasilkan Fagosit Sel matiSel mati Seluler debrisSeluler debris BakteriBakteri Pemaparan AntigenPemaparan Antigen Present antigen with MHC II molecules to helper T lymphocytesPresent antigen with MHC II molecules to helper T lymphocytes (T(THH cells)cells) IL-1 (a mitogenic protein for T lymohocytes)IL-1 (a mitogenic protein for T lymohocytes) IL-6, Il-8IL-6, Il-8 TNF-TNF- αα Interferon-Interferon- αα, -, -ββ; involved in fighting virus; involved in fighting virus Colony-stimulating factor (M-CSF)Colony-stimulating factor (M-CSF) Granulocyte-colony stimulating factor (G-CSF)Granulocyte-colony stimulating factor (G-CSF) Granulocyte-macrophage colony-stimulating factor (GM-CSF)Granulocyte-macrophage colony-stimulating factor (GM-CSF) ErythropoietinErythropoietin Platelet-derived growth factor (PDGF)Platelet-derived growth factor (PDGF) FUNGSI MAKROFAG
  9. 9. 9 Menghasilkan sekretMenghasilkan sekret khususkhusus Fibroblast growth factor (FGF)Fibroblast growth factor (FGF) Transforming growth factor-Transforming growth factor-ββ (TGF-(TGF- ββ)) Protease inhibitorsProtease inhibitors Elastase, collagenaseElastase, collagenase ProstaglandinsProstaglandins LeukotrienesLeukotrienes Neutral proteasesNeutral proteases Coagulation factors (II, VII, IX, X, XII)Coagulation factors (II, VII, IX, X, XII) ThrombospondinThrombospondin Plasminogen activatorPlasminogen activator Factor inducing monocytopoiesisFactor inducing monocytopoiesis Complement componenetsComplement componenets Pyrogens (mediate fever)Pyrogens (mediate fever) Proteoglycan-degrading enzymesProteoglycan-degrading enzymes Hydrogen peroxideHydrogen peroxide LipasesLipases SuperoxideSuperoxide FUNGSI MAKROFAG
  10. 10. 10 NAMA SELNAMA SEL FUNGSIFUNGSI TEMPATTEMPAT MacrophageMacrophage Fagositosis, antigenFagositosis, antigen presentationpresentation Loose (areolar) connectiveLoose (areolar) connective tissuetissue Peritoneal or pleuralPeritoneal or pleural macrophagesmacrophages FagositosisFagositosis Serous cavitiesSerous cavities MacrophageMacrophage Blood cell destruction,Blood cell destruction, antigen presentationantigen presentation Bone marrow, spleen,Bone marrow, spleen, thymus, lymph nodethymus, lymph node Alveolar macrophage (or dustAlveolar macrophage (or dust cell)cell) FagositosisFagositosis Alveoli of lungAlveoli of lung Sel LangerhansSel Langerhans Antigen presentationAntigen presentation EpidermisEpidermis Sel KuppferSel Kuppfer FagositosisFagositosis Liver (perinsinusoidalLiver (perinsinusoidal makrofag)makrofag) SISTEM MACROPHAGE
  11. 11. 11 NAMA SELNAMA SEL FUNGSIFUNGSI TEMPATTEMPAT MicrogliaMicroglia Fagositosis, antigenFagositosis, antigen presentationpresentation Sistem saraf pusatSistem saraf pusat Osteoklas (multinukleat)Osteoklas (multinukleat) Penyerapan tulangPenyerapan tulang Permukaan tulang (formPermukaan tulang (form from fusion of monocyte-from fusion of monocyte- derived macrophages)derived macrophages) Fibroblast –derivedFibroblast –derived macrophagemacrophage FagositosisFagositosis Lamina propria usus halusLamina propria usus halus Uterus-endometriumUterus-endometrium Foreign body giant cellForeign body giant cell (multinucleate)(multinucleate) FagositosisFagositosis Induced in areas of largeInduced in areas of large particulate material (e.g.,particulate material (e.g., talc on mesentery) (fusion oftalc on mesentery) (fusion of monocytes, macrophages)monocytes, macrophages) SISTEM MACROPHAGE
  12. 12. 12 HeparinHeparin (acidic GAG)(acidic GAG) Anticoagulant: binds to fibronectin, growthAnticoagulant: binds to fibronectin, growth factors, coagulation proteins, complementfactors, coagulation proteins, complement compounds; has anticancer activity, causescompounds; has anticancer activity, causes tumor regression, inhibits tumor metastasistumor regression, inhibits tumor metastasis Chondroitin sulfateChondroitin sulfate Sometimes present in mast cell granulesSometimes present in mast cell granules rather than heparin: thus, different types ofrather than heparin: thus, different types of mast cells existmast cells exist HistamineHistamine Causes contraction of smooth muscle ofCauses contraction of smooth muscle of bronchioles: causes increased capillarybronchioles: causes increased capillary permeability (leakiness)permeability (leakiness) LeukotrienesLeukotrienes (slow-reacting substance of(slow-reacting substance of anaphylaxis (SRS-A)anaphylaxis (SRS-A) Causes contraction of smooth muscle (notCauses contraction of smooth muscle (not stored in cell-synthesized from membranestored in cell-synthesized from membrane phospholipids)phospholipids) SUBSTANSI YANG DIHASILKAN OLEH SEL MAST
  13. 13. 13 Eosinophil chemotactic factor ofEosinophil chemotactic factor of anaphilaxis (ECF-A)anaphilaxis (ECF-A) Attracts eosinophils to regions of antigen-Attracts eosinophils to regions of antigen- antibody interaction; eosinophilsantibody interaction; eosinophils phagocytize antigen-antibody complexes:phagocytize antigen-antibody complexes: eosinophils produce histaminase, whicheosinophils produce histaminase, which depresses histamine effects, and aryldepresses histamine effects, and aryl sulfatase, which counteracts leukotrienessulfatase, which counteracts leukotrienes Lysosomal enzymesLysosomal enzymes IncludingIncluding ββ-glucuronidse, hexosaminidase,-glucuronidse, hexosaminidase, aryl sulfatasearyl sulfatase Functional role unclear: may degradeFunctional role unclear: may degrade GAGs in extracellular matrixGAGs in extracellular matrix Neutrophil chemotactic factor (NCF)Neutrophil chemotactic factor (NCF) Chemoattractant for neutrophilsChemoattractant for neutrophils Other subtancesOther subtances includeinclude platelet-activating factor, prostoglandinsplatelet-activating factor, prostoglandins (several), and(several), and neutralneutral proteasesproteases (tryptase, chymase) (most of the IgE molecules in the body are fixed on the(tryptase, chymase) (most of the IgE molecules in the body are fixed on the surface of mast cells rather than in the plasma)surface of mast cells rather than in the plasma) SUBSTANSI YANG DIHASILKAN OLEH SEL MAST

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