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Stuart Kim at Health Extension Salon #5

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Stuart Kim at Health Extension Salon #5

Prof. Kim presents publicly for the first time results from his lab: two newly discovered genetic variants present almost exclusively in supercentenarians may give clues that lead to therapies allowing all of us to have clean arteries and sharp minds at 110 years of age.

Prof. Kim presents publicly for the first time results from his lab: two newly discovered genetic variants present almost exclusively in supercentenarians may give clues that lead to therapies allowing all of us to have clean arteries and sharp minds at 110 years of age.

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Stuart Kim at Health Extension Salon #5

  1. 1. Whole Genome Sequencing of the World’s Oldest People Stuart Kim Lab, Stanford University Stephen Coles, GRG & Leroy Hood, ISB
  2. 2. World’s Oldest Human Jeanne Calment of Arles, France 1875-1997 122 yrs
  3. 3. Longevity is Heritable From Gross L., 2006
  4. 4. There are only 17 Supercentenarians alive in the US today. 10,000,000,000 1,000,000,000 313,000,000 100,000,000 Number of people 10,000,000 1,000,000 70,000 100,000 10,000 1,000 100 17 10 US Centenarians Supercentenarians Source: Gerontology Research Grouphttp://www.grg.org/Adams/E.HTM
  5. 5. Life expectancy of supercentenarian siblings is 8-14 years above average. 85 Supercentenarian Sibling Average age at death 80 US cohort 75 Swedish cohort 70 65 60 Male Female Adapted from Perls et al. 2007
  6. 6. Whole Genome Sequencing of the World’s Oldest People Gerontology Research Group Dr. Kristen Fortney Dr. Hinco Gierman Dr. L. Stephen Coles Dr. Lee Hood
  7. 7. Identify genes that have mutations in supercentenarians
  8. 8. Two genes are significant
  9. 9. Gene B mutations in supercentenarians 7 mutations/17 supercentenarians 30 mutations/4300 control genomes P < .005 (Bonferroni corrected)
  10. 10. A gene for human longevity?
  11. 11. Acknowledgments Gerontology Research Group Dr. Kristen Fortney Dr. Hinco Gierman Dr. L. Stephen Coles Dr. Lee Hood

Editor's Notes

  • Thank you Tom, and thank you so much
  • (only data shown for siblings age &gt;20 years)
  • Alternate slide 9 (fewer details on specific mutations)

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