Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
Whole Genome Sequencing of
 the World’s Oldest People




    Stuart Kim Lab, Stanford University
  Stephen Coles, GRG & L...
World’s Oldest Human
Jeanne Calment
of Arles, France

1875-1997
122 yrs
Longevity is Heritable




                From Gross L., 2006
There are only 17 Supercentenarians
                    alive in the US today.
                   10,000,000,000
         ...
Life expectancy of supercentenarian
siblings is 8-14 years above average.

                         85
                   ...
Whole Genome Sequencing of the
      World’s Oldest People
                                        Gerontology Research Gr...
Identify genes that have mutations in
          supercentenarians
Two genes are significant
Gene B mutations in
               supercentenarians




7 mutations/17 supercentenarians

30 mutations/4300 control genom...
A gene for human longevity?
Acknowledgments



                                        Gerontology
                                         Research
 ...
Upcoming SlideShare
Loading in …5
×

of

Stuart Kim at Health Extension Salon #5 Slide 1 Stuart Kim at Health Extension Salon #5 Slide 2 Stuart Kim at Health Extension Salon #5 Slide 3 Stuart Kim at Health Extension Salon #5 Slide 4 Stuart Kim at Health Extension Salon #5 Slide 5 Stuart Kim at Health Extension Salon #5 Slide 6 Stuart Kim at Health Extension Salon #5 Slide 7 Stuart Kim at Health Extension Salon #5 Slide 8 Stuart Kim at Health Extension Salon #5 Slide 9 Stuart Kim at Health Extension Salon #5 Slide 10 Stuart Kim at Health Extension Salon #5 Slide 11
Upcoming SlideShare
Judith Campisi at Health Extension Salon #3
Next

0 Likes

Share

Stuart Kim at Health Extension Salon #5

Prof. Kim presents publicly for the first time results from his lab: two newly discovered genetic variants present almost exclusively in supercentenarians may give clues that lead to therapies allowing all of us to have clean arteries and sharp minds at 110 years of age.

Related Books

Free with a 30 day trial from Scribd

See all
  • Be the first to like this

Stuart Kim at Health Extension Salon #5

  1. 1. Whole Genome Sequencing of the World’s Oldest People Stuart Kim Lab, Stanford University Stephen Coles, GRG & Leroy Hood, ISB
  2. 2. World’s Oldest Human Jeanne Calment of Arles, France 1875-1997 122 yrs
  3. 3. Longevity is Heritable From Gross L., 2006
  4. 4. There are only 17 Supercentenarians alive in the US today. 10,000,000,000 1,000,000,000 313,000,000 100,000,000 Number of people 10,000,000 1,000,000 70,000 100,000 10,000 1,000 100 17 10 US Centenarians Supercentenarians Source: Gerontology Research Grouphttp://www.grg.org/Adams/E.HTM
  5. 5. Life expectancy of supercentenarian siblings is 8-14 years above average. 85 Supercentenarian Sibling Average age at death 80 US cohort 75 Swedish cohort 70 65 60 Male Female Adapted from Perls et al. 2007
  6. 6. Whole Genome Sequencing of the World’s Oldest People Gerontology Research Group Dr. Kristen Fortney Dr. Hinco Gierman Dr. L. Stephen Coles Dr. Lee Hood
  7. 7. Identify genes that have mutations in supercentenarians
  8. 8. Two genes are significant
  9. 9. Gene B mutations in supercentenarians 7 mutations/17 supercentenarians 30 mutations/4300 control genomes P < .005 (Bonferroni corrected)
  10. 10. A gene for human longevity?
  11. 11. Acknowledgments Gerontology Research Group Dr. Kristen Fortney Dr. Hinco Gierman Dr. L. Stephen Coles Dr. Lee Hood

Prof. Kim presents publicly for the first time results from his lab: two newly discovered genetic variants present almost exclusively in supercentenarians may give clues that lead to therapies allowing all of us to have clean arteries and sharp minds at 110 years of age.

Views

Total views

1,400

On Slideshare

0

From embeds

0

Number of embeds

796

Actions

Downloads

0

Shares

0

Comments

0

Likes

0

×