Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Dr. Saul Villeda at Health Extension Salon #6

1,892 views

Published on

Saul presents the results of his work in joining the blood systems of young animals to young animals, in which the old animals become younger. These heterchronic parabiosis experiments raise new questions: is it something in young blood that helps the old animals? Or a dilution of the old animals' blood? Will this work in humans? Will it extend lifespan? Many more experiments to try!

Published in: Health & Medicine
  • Be the first to comment

  • Be the first to like this

Dr. Saul Villeda at Health Extension Salon #6

  1. 1. Young Blood and Brain Aging Saul Villeda, PhD University of California San Francisco Eli and Edythe Stem Cell Institute
  2. 2. Aging is a process affecting every individual
  3. 3. Aging is associated with a decline in cognitive functions Hedden and Gabriel Nat. Rev. Neurosci 2004
  4. 4. Aging is associated with a decline in cognitive functions AgingYoung Old
  5. 5. Question: Can the effects of aging on cognitive function be reversed? Aging Young Old
  6. 6. Stem cells and tissue regeneration
  7. 7. Stem cells and tissue regeneration
  8. 8. Stem cells and tissue regeneration
  9. 9. Stem cells and tissue regeneration
  10. 10. Stem cells and tissue regeneration
  11. 11. Palmer et al. J Comp. Neurol. 2000Mirzadeh et al. Cell Stem Cell 2008
  12. 12. Reviewed by Zhao et al. Cell 2008
  13. 13. Reviewed by Zhao et al. Cell 2008
  14. 14. Reviewed by Zhao et al. Cell 2008
  15. 15. Aging impairs neural stem cells and associated cognitive function Reviewed by Lazarov et al. Trends Neurosci 2010
  16. 16. Aging impairs neural stem cells and associated cognitive function Reviewed by Lazarov et al. Trends Neurosci 2010
  17. 17. Systemic perturbations in old animals enhances neural stem cell and cognitive functions Van Praag et al. J. Neurosci. 2005
  18. 18. Systemic perturbations in old animals enhances neural stem cell and cognitive functions Van Praag et al. J. Neurosci. 2005
  19. 19. Hypothesis Changes naturally occuring in the agingsystemic milieu (blood) impair neural stem cell and cognitive functions
  20. 20. Using parabiosis surgery to investigate changes in the young and old brain Old-Young Pioneered by Rando Conboy et al. Nature 2005
  21. 21. Using parabiosis surgery to investigate changes in the young and old brain Young-Young Old-Young Old-Old Pioneered by Rando Conboy et al. Nature 2005
  22. 22. Exposure to old blood impairs neural stem cell function in young mice Old Blood Parabiosis Villeda et al. Nature 2011
  23. 23. Villeda et al. Nature 2011
  24. 24. Old = YoungVilleda et al. Nature 2011
  25. 25. Exposure to old blood impairs cognitive function in young mice Old Blood Cognitive Impairments Parabiosis Villeda et al. Nature 2011
  26. 26. Exposure to young blood enhances neural stem Stem cells and tissue regeneration cell function in old animals Villeda et al. Nature 2011
  27. 27. Systemic exposure to young blood enhances neural stem cell function in old mice Old = Young Villeda et al. Nature 2011
  28. 28. Systemic exposure to young blood enhances neural stem cell function in old mice Old = Young Villeda et al. Nature 2011
  29. 29. Exposure to young blood rejuvenates stem cell Stem cells and tissue regeneration function in old animals Muscle Cells Young Blood Neurons Tissue Specific Stem Cells Blood Cells Conboy et al. Nature 2005, Brack et al. Science 2007, Villeda et al. Nature 2011, Ruckh et al. Cell Stem Cell 2012
  30. 30. Question: Can the beneficial effects of young blood extend beyond stem cell function? Rejuvenation ?
  31. 31. Exposure to young blood improvescommunication between neurons in the old brain Old-Old Old-Young Rejuvenation
  32. 32. Exposure to young blood improves learning and memory in old animals Rejuvenation Cognitive Improvements
  33. 33. Testing hippocampal-dependent spatial learning and memoryRadial Arm Water Maze DAY 1: Training Phase DAY 1: Training Phase Villeda et al. Nature 2011
  34. 34. Exposure to young blood improves learning and memory in old animals
  35. 35. Direction of the LabUnderstanding how administration of young blood late in life improves the old brain Rejuvenation Function Genes Cognition Cells
  36. 36. AcknowledgementsVilleda Lab: Collaborators: Lucas Smith  Thomas Rando Kristopher Plambeck (Stanford/VA Palo Alto) Jill Bouchard  Xinmen Xie (AfaSci) Liz Wheatley  Bende Zou (AfaSci)  Marion Buckwalter (Stanford)Wyss-Coray Lab:  Theo Palmer (Stanford)  Ge Li (VA Seattle) Tony Wyss-Coray  Elaine R. Peskind (VA Seattle) Jeong-Soo Park  Jeffrey A. Kaye Yingbo He (Oregon Health Sciences) Greg Bieri  Joseph F. Quinn Jian Luo (Oregon Health Sciences) Kira Irving  Douglas R. Galasko (UCSD) Rafael Wabhl Markus Britschgi Alex Eggel Funding: Ching Ding Trisha Stan  UCSF Fellows (Sandler Eva Czirr Foundation) Kurt Lucin  NIH Director’s Jinte Middledorp Independence Award Daniella Birdnik  CIRM Award Joseph Castellano  NIA
  37. 37. The Villeda Lab at UCSF COGNITION AGING REJUVENATION

×