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The "International Chemical Ontology Network" is established by major chemical industries in order to elaborate and understand the connections in the Big Data collections of chemistry / pharmacology. The collections come from the different natural sciences and human sciences and can only be explained or experienced in overlapping structures and connections. In this way, new innovative approaches are to be defined, new knowledge generated, products produced and marketed. Thus, the whole value creation process can be simulated and defined in the initial phase of a project, and it is possible to counteract unfavorable developments even at a very early stage. The clear structure and the incorporation of all relevant and common rules will help to improve the understanding of overlapping structures in the research, development and production processes, which will lead to a considerable saving of costs and resources, Full innovation potential of the industry 4.0 approach.