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Christopher Southan (The IUPHAR/BPS Guide to PHARMACOLOGY, UK)
While the raison d'être of patents is Intellectual Property (IP) there is a growing awareness of the scientific value of their data content. This is particularly so in medicinal chemistry and associated bioactivity domains where disclosed compounds and associated data not only exceeds that published in papers by several-fold and surfaces years earlier, but is also, paradoxically; completely open (i.e. no paywalls). Scientists have traditionally extracted their own relationships or used commercial sources but the last few years have seen a “big bang” in patent extractions submitted to open databases, including nearly 20 million structures now in PubChem.
This tutorial will:
Outline the statistics of patent chemistry in various open sources
Introduce a spectrum of open resources and tools
Enable an understanding of target identification, bioactivity and SAR extraction from patents and connecting these relationships to papers
Cover aspects of medicinal chemistry patent mining
Include hands on exercises using open source antimalarial research as examples
The focus will be on public databases and patent office portals, since these can be transparently demonstrated. However, the essential complementarity with commercial resources will be touched on. Those engaged in Competitive Intelligence will also find the material relevant.