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Iron Poisoning


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Iron Poisoning

  2. 2. SOURCES WITH AN EXCESS OF IRON(EXCESSIVELY CONSUMING WHICH MAY LEADTO TOXICITY) White Flour products Some iron supplements, containing iron alone as the ingredient. Red meat, especially beef. Pollution -- Iron contamination of the air, water and soil is quite common, especially in iron-producing areas.
  3. 3. SOURCES WITH AN EXCESS OF IRON(EXCESSIVELY CONSUMING WHICH MAY LEADTO TOXICITY) Occupational Exposure. Welders, electrical workers who use solder, iron and pipe workers. Congenital Iron Toxicity (excessive iron present at birth). Most children today are born with some excess iron. They may still be anemic because their iron is not all bioavailable.
  4. 4. SOURCES WITH AN EXCESS OF IRON(EXCESSIVELY CONSUMING WHICH MAY LEADTO TOXICITY) Emotional Iron Sources. Holding on to one’s anger or rage appears to keep iron in the body. While this is not a source of iron toxicity, it still has an extremely damaging effect.
  5. 5. IRON’S EFFECTS ON THE BODY Iron Replaces Other Vital Minerals Causing Enzyme Dysfunction. Inflammation. When iron replaces other elements in the body, in addition to enzyme malfunction, the next most important problem it causes is inflammation. Toxic Iron Oxide. Iron oxide is formed when iron combines with several atoms of oxygen at once. It is biologically useless and quite toxic as well Bacterial Growth Stimulant. Due to its properties as an excellent oxygen transporter, iron tends to stimulate the growth of common bacteria. Cellular Poison (Cancer). Imbalances related to iron reduce the output of cellular energy in the body. This leads directly to cancer
  6. 6. ORGANS AFFECTED BY IRON OVERLOAD Organs that may be most affected by iron are the pancreas, liver, kidneys, brain, heart, a rteries, and joints.
  7. 7. ACUTE POISONING Pain in the stomach (due to ulceration) Nausea, vomiting The pain then reduces for 24 hours as the iron passes deeper into the body and damages internal organs, particularly the brain, kidneys and liver, and metabolic acidosis develops (due to renal insufficiency). The body goes into shock and so occurs death from liver failure.
  8. 8. CHRONIC POISONING Diabetes (referred to as bronze diabetes): Iron replaces many minerals that can give rise to symptoms of diabetes. Cancers Nervous System Diseases. These may include Parkinson’s disease, Alzheimer’s disease and behavioral abnormalities, including violence, anti-social behavior, ADHD, autistic characteristics and other. A bad temper is often related to iron toxicity, as mentioned earlier. Hypertension Renal Failure Inflammatory symptoms
  9. 9. FATAL DOSE The therapeutic dose for iron deficiency anaemia is 3–6 mg/kg/day. Toxic effects begin to occur at doses above 10–20 mg/kg of elemental iron. Ingestions of more than 50 mg/kg of elemental iron are associated with severe toxicity.
  10. 10. TREATMENT Chelating agents, such as deferoxamine. Iron Antagonists: These include minerals such as zinc, selenium, sulphur, and manganese. Dialysis Phlebotomy
  11. 11. MEDICOLEGAL ASPECTS Iron toxicity has been primarily associated with young children who consumed large quantities of iron supplement pills, which resemble sweets and are widely used. Excessive dietary intake of iron is not yet associated with bodily effects too large to indicate serious toxicity.
  12. 12. POSTMARTOM APPEARANCE Elevated iron concentrations in most major body organs: Liver, stomach, brain, heart, lungs, small bowel and kidneys, indicating oxidative damage. Congestion, edema, necrosis, and iron deposition in gastric and intestinal mucosa. Haemorrhage and congestion in the lungs.