In this presentation, we will introduce Hotspot's Garbage First collector (G1GC) as the most suitable collector for latency-sensitive applications running with large memory environments. We will first discuss G1GC internal operations and tuning opportunities, and also cover tuning flags that set desired GC pause targets, change adaptive GC thresholds, and adjust GC activities at runtime. We will provide several HBase case studies using Java heaps as large as 100GB that show how to best tune applications to remove unpredicted, protracted GC pauses.