Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

L methylfolate The New face of Folic Acid


Published on

Facts about folic acid metabolism and the new form of folic acid

Published in: Health & Medicine

L methylfolate The New face of Folic Acid

  1. 1. Folate
  2. 2.   Folic acid is a water-soluble vitamin B9. It is also known as vitamin B9, vitamin Bc or folacin and folate (the naturally occurring form)
  3. 3.  Folate is found naturally in some foods, including leafy vegetables, citrus fruits, beans (legumes), liver and whole grains  Folic Acid is found in various products as a food supplement.  "Folic acid" is the term used for the man-made or synthetic form of the vitamin.
  4. 4. RDI= Refrence Daily Intake, UL=tolerable upper intake levels
  5. 5.   Folic Acid is essential to numerous bodily functions. The human body needs folate to synthesize DNA and repair DNA, as well as to act as a cofactor in biological reactions involving folate.
  6. 6.   Folic Acid is especially important in aiding rapid cell division and growth, such as in infancy and pregnancy. Children and adults both require folic acid to produce healthy red blood cells and prevent anemia. Since folate deficiency limits cell division, erythropoiesis is hindered and leads to megaloblastic anemia
  7. 7.  A lack (deficiency) of folate in the human body can be caused by certain diseases,  by taking certain medications, or  by not getting enough folate in your diet 
  8. 8.  Deficiency can result in many health problems, the most notable one being neural tube defects in developing embryos which includes NTDs( Neural Tube Defects) i.e.   Anencephaly Spina Bifida
  9. 9. Common symptoms of folate deficiency include:  diarrhea,  macrocytic anemia with weakness or shortness of breath,  nerve damage with weakness and limb numbness (peripheral neuropathy),  pregnancy complications such as NTDs, recurrent pregnancy loss, low birth weight  mental confusion,  forgetfulness or other cognitive declines,  mental depression,  sore or swollen tongue,  peptic or mouth ulcers,  headaches,  heart palpitations,  Irritability, and behavioral disorders
  10. 10. Anencephaly is the absence of a large part of the brain and the skull  Anencephaly is a neural tube defect that occurs when the cephalic (head) end of the neural tube fails to close, usually between the 23rd and 26th day of pregnancy, resulting in the absence of a major portion of the brain, skull, and scalp
  11. 11.    Infants born with anencephaly are usually blind, deaf, unconscious, and unable to feel pain There is no cure or standard treatment for anencephaly Most anencephalic babies do not survive birth. If the infant is not stillborn, then he or she will usually die within a few hours or days after birth.
  12. 12.   Spina bifida literally means ‘split spine’ A fault in the development of the spinal cord and surrounding bones (vertebrae) leaves a gap or split in the spine. The spinal cord has not formed properly, and may also be damaged.
  13. 13.     Spina bifida is a developmental disorder caused by the incomplete closing of the embryonic neural tube Complications of spina bifida can range from minor physical problems to severe physical and mental disabilities It can lead to varying degree of loss of muscle function and sensation Surgery has made it possible to treat mild cases by closure of the defect and orthopedic procedures can be applied to balance muscle power
  14. 14.    At present causation is unknown and research continues. However, we do know that taking folic acid supplements can reduce the risk of spina bifida in unborn babies. For families with no history of spina bifida it is recmomended that women take an ‘over the counter’ dose of 400mcg daily. For families where there is a history of spina bifida, a prescription dose (5mg) of folic acid is needed
  15. 15.  Contains contains L-Methylfolate 400mcg L-Methylfolate is the biologically active form of folic acid  L-Methylfolate is the natural, active form of folic acid used at the cellular level  It bypasses several metabolic steps in the body as it is already present in the absorbable form  is an orally administered prescription medical food for the management of low folate levels 
  16. 16. DHF Reductase Enzyme MTHFR DHF = Di-hydrofolate MTHFR= Methylene-tetra-hydrofolate
  17. 17. L-methylfolate is a Novel form of Folate More effective than folic acid  L-methylfolate is a high absorbable form of folic acid  L-methylfolate is the bioactive form of folic acid ready to use at cellular level.  Unlike regular folic acid, L-methylfolate does not require enzymatic conversion to L-methylfolate in the body  L-methylfolate is 7 times more bioavailable than folic acid  L-methylfolate is less likely to mask a vitamin B deficiency compared to folic acid  L-methylfolate increases RBC folate better than folic acid 
  18. 18.  Hifol Tablets 2×15’s  Price is Rs.200.00/pack
  19. 19.  Hifol Detailing Story