Thank you to the BSI for supporting this poster:
A unique access-point to
immunological data in
Develop new pages and
extend search mechanism
for immunological data
Assist in the identification
of novel therapeutic
Assist in identifying
S. D. Harding1
, E. Faccenda1
, S. Ireland1
, A. J. Pawson1
, J. L. Sharman1
, C. Southan1
, S. P. Alexander2
, C. Bryant4
, A. P. Davenport5
, C. Doerig6
, D. Fabbro7
, F. Levi-Schaffer8
, M. Spedding9
, J. A. Davies1
1Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UNITED KINGDOM, 2Life Sciences, University of Nottingham, Nottingham, UNITED KINGDOM,3MRC Centre for Inflammation Research, QMRI, University
of Edinburgh, Edinburgh, UNITED KINGDOM, 4
Veterinary Medicine, University of Cambridge, Cambridge, UNITED KINGDOM,5
Clinical Pharmacology Unit, University of Cambridge, Cambridge, UNITED KINGDOM, 6
Department of Microbiology, Monash
University, Clayton, AUSTRALIA, 7PIQUR Therapeutics AG, Basel, SWITZERLAND, 8School of Pharmacy, Institute for Drug Research, Hebrew University of Jerusalem, Jerusalem, ISRAEL, 9Spedding Research Solutions SARL, Le Vesinet, FRANCE.
Immune/inflammatory/infection responses and disorders are a major focus of
pharmacological R&D. Chronic diseases, aspects of ageing and progress of infection all
have, or depend strongly on, an immune, or inflammatory, component. Being able to
modulate these more effectively with better drugs would be immensely valuable.
Development of these drugs will benefit from improved data exchange between the
immunology expert and pharmacology expert communities.
What is the Guide to IMMUNOPHARMACOLOGY
Our Wellcome Trust-funded project to produce the IUPHAR Guide to
IMMUNOPHARMACOLOGY (GtoImmuPdb) addresses this need by providing a new
portal to the existing IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb), that is both
'immunologist-friendly' for pharmacological information and 'pharmacologist-friendly'
for accessing immunological agents and targets. GtoImmuPdb will be a freely-available,
regularly updated and richly annotated resource. Curated by expert NC-IUPHAR*
sub-committees, including additional contributors with expertise in immunity,
inflammation and kinase biology.
The GtoP database has been enriched by tagging targets & ligands of
immunological relevance and by linking these to immunological processes, cell
types and relevant diseases.
Beta-version v2.0 available at:
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb) is an open access
resource providing overviews of key properties, background reading and
selective ligands of a wide range of biological targets.
The searchable database provides
quantitative information on drug
targets and the prescription medicines
and experimental drugs that act on
them. For ligands, data on approved
status, clinical use and mechanism of
action are included.
* International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug
1. Harding SD, et al. (2018) The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: Updates and expansion to
encompass the new Guide to IMMUNOPHARMACOLOGY. Nucl. Acids Res. PMID: 29149325
2. Cell Ontology, http://obofoundry.org/ontology/cl.html ontology.org
3. Gene Ontology Consortium, http://geneontology.org
Human targets in GtoPdb, 2017.5 release
Ligand classes in GtoPdb, 2017.5 release
The 2017.5 release (August 2017)
of the database contains over
15,200 curated interactions across
1,684 human targets and 8,978
ligands. More specifically, the
database contains 1,431 human
targets that have quantitative
interactions to a ligand.
Immuno Process and Cell Type Data
GtoImmuPdb presents a set of top-level immunological process and cell type
categories against which targets in the database can be annotated and which
form the basis of organising, navigating and searching for immunological
process and cell type associations.
Subsets of these ontologies are mapped to each top-level category. This then
forms the basis of searches which will detect any cell type or process
associations annotated with those terms (or their children).
Target detailed view pages
display process and cell
Including detailed curator
comments and links to
As of 9 Oct 2017 the development GtoImmuPdb held 455 protein targets
and 816 ligands tagged as being of immunological relevance.
GtoImmuPdb uses both
against which to
annotate. Displaying GtoImmuPdb data in detailed view of BTK
Immuno Cell Types
Innate lymphoid cells
Macrophages & monocytes
Natural killer cells
Other T cells
B cell (activation)
Chemotaxis & migration
Cytokine production & signalling
Immune system development
T cell (activation)
Cell types Processes
Target family pages use a toggle
to switch between GtoPdb &
Ligand lists highlight
immuno relevant ligands
with new icons.
Here showing inhibitors
IUPHAR Guide to