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Curriculum vitae 03-29-2016

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Curriculum vitae 03-29-2016

  1. 1. CURRICULUM VITAE Date Prepared: 03/29/2016 Name: Gokhan Baris Ozdener Office Address: Department of Molecular & Cell Biology, 700 Albany Street; W-216 Boston, MA 02118 Home Address: 21 Walnut Street Apt #8 Quincy, Ma 02171, U.S.A E-mail: ozzbaris@gmail.com Place ofBirth: Denizli, TURKEY CareerObjective:Seeking a research fellow role where I can integrate my scientific, clinical skills and team work skills for cancer research, drug discovery and delivery. Award/Prices: High SchoolResearch Project Competition Award 1st prize in Physics and Energy Efficiency Categories Scientific and Technological Research Council of Turkey (TUBITAK), 1993. Departmental Fellowships Award (Boston University Molecular and Cell Biology Department), 2010-2011. Graduate Fellowships Award (Boston University), 2011-2013. Graduate Research Assistant Scholarship/Stipend Award (Boston University), 2013-2014.
  2. 2. 2016 Science Day at BostonUniversity GSDM Poster Competition/ PostdoctoralFellows 1st Place Award, 2016. PersonalProfile: Experience in biology research and dentistry enhanced wide range of transferable skills-problem solving, self-motivation, independent work and team working-that equip me for a career in a research environment combined with clinical applications in medical field. My aim is to work in a challenging, team based multiple projects that enable personal development. Languages: Turkish: Native proficiency English: Full professional proficiency Italian: Elementary proficiency Certifications: Professional Association of Diving Instructors (PADI) Open Water Diver American Heart Association Basic Life Support(BLS) Health Care Provider (CPR and AED) Education: ExpectedGraduation, 2018: Henry M. Goldman Schoolof Dental Medicine at Boston University, Boston, USA. Advanced Standing for Internationally Trained Dentists (AS), DMD 2014-2015: Molecular and Cell Biology Department, Boston University, Boston, USA. Diploma Dissertation: “Macropinocytosis and Caveola- Dependent Endocytosis are Major Uptake Pathways for Lysyl Oxidase Propeptide”
  3. 3. 2010-2014: Boston University, Boston, USA. Doctorof Science (D.Sc.)in Molecularand Cell Biology -Design, synthesis and fluorescent labeling of a recombinant protein lysyl oxidase propeptide (rLOX-PP) as a cancer therapeutic. -Studied the cellular/nuclear entry and pH buffering mechanism of rLOX- PP to further tune-up its accumulation in cancer cell lines. -Studied rLOX-PP interaction with DNA repair pathway on prostate cancer xenograft growth. -Studied endosomal escape, recycling and enhanced delivery of rLOX-PP by employing pH sensitive nano- particles. -Developed dark quencher compound usage for Flow Cytometry and ConfocalMicroscopy. -Studied pH modulation effect of rLOX-PP on macropinocytosis and developing an efficient cytoplasmic delivery for its intra-cellular targets. -Studied rLOX-PP interaction with its extra-cellular targets Syndecan 4 and 1 in cancer cell lines. -Developed networking, presentation and interpersonal skills through the attendance of conferences. -Worked independently to design and plan nature of work, overcome problems and manage workload. 2001-2002: Ege University Schoolof Dental Medicine, Izmir, Turkey. Diploma Dissertationand Masterof Science Degree(MSc) “Comparison of the Advantages of Magnetic Resonance (MR), Computerized Tomography (CT), and Diagnostic Sonography As Visualization Techniques for Cancer Diagnosis in Maxillofacial Area.” directed by Prof. Dr. Nesrin Dundar. 1994-2002: Ege University School of Dental Medicine, Izmir, Turkey. Doctorof Dental Surgery (DDS) -Enhanced problem solving skills and interpersonal skills through theoretical classes and dental clinics. -Acquired clinical skills in scientific environment. -Gained knowledge for intensive case-based problem solving.
  4. 4. 1991-1993: Erzurum Science High School, Erzurum, Turkey. -National First Prize for Physics Projectin NationalScience ProjectCompetition for High Schools (TUBITAK), 1993. -Gained theoretical and experimental problem solving skills. -Built self-discipline for studying strategies. ResearchInterests: Molecular Biology of Cancer, Gene Therapy, Targeting Cellular Signaling Pathways, Drug Discovery, Molecular Neuroscience, Biological Therapeutics for Cancer, Dental Research, Delivery and Nanoparticles. ResearchExperiences: January 2015-Present: Post-DoctoralAssociate Department of Molecular and Cell Biology at BostonUniversity’s Henry M. Goldman Schoolof Dental Medicine (GSDM), directed by Prof. Philip C. Trackman. September 2010-January2015: D.Sc. Student and ResearchAssistant Department of Molecular and Cell Biology at BostonUniversity’s Henry M. Goldman Schoolof Dental Medicine (GSDM), directed by Prof. Philip C. Trackman. March 2009-August2010: ResearchAssistant Massachusetts General Hospital/Harvard Medical School (MGH) Neurogenetics Unit, directed by Prof. Xandra O. Breakefield (Dr. Okay Saydam’s group).
  5. 5. 2001-2002: Graduate ResearchAssistant Ege University Schoolof Dental Medicine: Diploma Dissertation Studies directed by Prof. Dr. Nesrin Dundar. ProfessionalExperiences: April 2006-December2006: Doctor of Dental Surgery (DDS), Didim Estetica Ağız ve Dis Sagligi Poliklinigi,Aydin, Turkey. Phone: 00 90 256 813 63 85, 00 90 256 813 64 00 E-mail: info@esteticadental.com.tr October2004-March2006: DDS, Self-employed Dental Office, Izmir,Turkey. April 2003-October2004: DDS, Izmir Can Tip Merkezi, Izmir, Turkey. Phone: 00 90 232 264 32 19, 00 90 232 264 69 69 Publications: Peerreviewed articles: -Gokhan Baris Ozdener, Manish V. Bais, Philip C. Trackman. “Determination of Cell Uptake Pathways for Tumor Inhibitor Lysyl Oxidase Propeptide.” Molecular Oncology. 2015 Aug 6. pii: S1574-7891(15)00145-3. -Manish Bais , GokhanOzdener , Gail E. Sonenshein and Trackman PC. “Effects of Tumor SuppresorLysyl Oxidase Propeptide on Prostate Cancer Xenograft Growth and Its Direct Interactions with DNA Repair Pathways.” Oncogene. Dec 2013; ONC-2013-01199. -Mizrak A, Bolukbasi MF, Ozdener GB, Brenner GJ, Madlener S, Erkan EP, StröbelT, Breakefield XO, Saydam O. “Genetically Engineered Microvesicles Carrying Suicide
  6. 6. mRNA/Protein Inhibit Schwannoma Tumor Growth.” Mol Ther. 2013 Jan;21(1):101-8. -Mehmet Fatih Bolukbasi, Arda Mizrak, Ozdener GB, Sibylle Madlener, Thomas Ströbel, Erdogan Pekcan Erkan, Jian-Bing Fan, Xandra O. Breakefield, and Okay Saydam “miR-1289 and ‘Zipcode’-like Sequence Enrich mRNAs in Microvesicles” Mol Ther Nucleic Acids. 2012 February; 1(2): e10. -Saydam O, Senol O, Würdinger T, Mizrak A, Ozdener GB, Stemmer-Rachamimov AO, Yi M, Stephens RM, Krichevsky AM, Saydam N,Brenner GJ, Breakefield XO. “miRNA-7 attenuation in Schwannoma tumors stimulates growth by upregulating three oncogenic signaling pathways.” Cancer Res. 2011 Feb 1;71(3):852-61. - Saydam O, Ozdener GB, Senol O, Mizrak A, Prabhakar S, Stemmer-Rachamimov AO, Breakefield XO, Brenner GJ.“A novel imaging-compatible sciatic nerve schwannoma model.” J Neurosci Methods. 2011 Jan 30;195(1):75-7. Book Chapter: -Arda Mizrak, Ozlem Senol, Baris GokhanOzdener, Okay Saydam. “miR-200a Regulation of the Wnt Signaling in Meningioma Tumorigenesis.” Tumors of the Central Nervous System Volume 7, pp 59-67 (2012). Presentations (Oraland PosterPresentations atConferences): - GokhanBaris Ozdener, Philip C. Trackman. Lysyl oxidase propeptide (LOX-PP) inhibits oral cancer metastasis and tumor growth by interacting with Stromal cell- derived factor 1 (SDF-1), syndecan-4 (SDC-4) and syndecan-1 (SDC-1). International Conference on Periodontics and Prosthodontics/June, 2016 New Orleans, USA (Organizing Committee Member). - GokhanBaris Ozdener, Philip C. Trackman. Vacuolar/Cytoplasmic pH Gradient by Inhibitors of ATP and Ionophores Increase Cell Uptake and Endosomal Escape of the
  7. 7. Tumor SuppressorLysyl Oxidase Propeptide (rLOX-PP). Science Day 2016 at Boston University GSDM. -Gokhan Baris Ozdener, Manish V. Bais, Philip C. Trackman. “Determination of Cell Uptake Pathways for Tumor Inhibitor Lysyl Oxidase Propeptide.” Etiology and Pathogenesis of Oral Cancer the Affinity Research Collaboratives (EPOC ARC) Symposium, October, 2015 - GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman. “Macropinocytosis Uptake Pathways for the Lysyl Oxidase Propeptide(rLOX-PP). Head & Neck Cancer Symposium at BostonUniversity GSDM and Dana-Farber (September, 2015). - GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman. “Macropinocytosis Uptake Pathways for the Lysyl Oxidase Propeptide(rLOX-PP).” The 93rd General Session & Exhibition of the International Association for Dental Research (IADR) and the 44th of the AADR (March, 2015). - GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman. “Macropinocytosis and Caveola - dependent Endocytosis Are Major Cell Uptake Pathways for the Tumor Inhibitor Lysyl Oxidase Propeptide” Science Day 2015 at Boston University GSDM. - GokhanBaris Ozdener, Manish V. Bais Philip C. Trackman. “Cellular Uptake of rLOX-PP Involves Phosphatidylinositol 3- kinase (PI3K) Dependent, HSPG Mediated Macropinocytosis, Caveola - dependent Endocytosis.rLOX- PP alkalizes endosomes via modulating endosomal pH.” Science Day 2014 at Boston University GSDM. - Mehmet Fatih Bolukbasi, Arda Mizrak, GokhanBaris Ozdener, Sibylle Madlener, Thomas Ströbel, Erdogan Pekcan Erkan, Jian- Bing Fan, Xandra O. Breakefield and Okay Saydam. “miR-1289 and “zipcode”-like sequence enrich mRNAs in microvesicles.” Scientific Program, International Society of Extracellular Vesicles (ISEV) meeting 2012.
  8. 8. Articles in preparation: -Ozdener G.B., Trackman Philip C. “Developing BSA-QSY9 quencher for flow cytomety and confocalmicroscopyto quench red fluorescent emiting dyes”. (Manuscript writing) -Ozdener GB, Bais M., Trackman Philip C. “Syndecan 1 and 4 involved ras-dependent macropinocytosis and caveola- dependent pathways are major pathway for cellular uptake of LOX-PP in various cell lines and their cancerous partners”. -Ozdener G.B., Trackman Philip C. “rLOX-PP stimulates macropinocytosis by increasing submembranous pH and activating Rac1 and Cdc42signaling.” -Ozdener G.B., Trackman Philip C. “The uptake of LOX-PP from cytoplasm to nucleus is KPNA4 and KPNB1 dependent in DU1453 and PC-3 cell lines.” -Ozdener G.B., Trackman Philip C. “Cholesterol sequestration by filipin enhances the uptake and activity of rLOX-PP in cancer cells via activating clathrin-dependent uptake pathway.” References: Xandra O. Breakefield, PhD. Professorof Neurology, Molecular Neurogenetics Unit Massachusetts General Hospital- East Building 149, 6th floor 13th Street Charlestown, MA 02129, USA Phone: 617-726-572 Fax: 617-724-1537 Email: breakefield@hms.harvard.edu
  9. 9. Philip C. Trackman, PhD. Director, Graduate Programs in the Department of Molecular & Cell Biology, Professor, Department of Molecular & Cell Biology, At Boston University 700 Albany Street. Boston, MA 02118, USA Phone: 617-638-4076 Email: trackman@bu.edu Okay Saydam, PhD. ProfessorofNeuro-Oncology, Molecular Neuro-Oncology Research Unit, Division of Neuro- Oncology, Department of Pediatrics, Medical University of Vienna, Vienna,AUSTRIA Phone: 01-40400-2146 or -3485 Email: okay.saydam@meduniwien.ac.at Manish Bais, PhD. Assistant Professorin the Department of Molecular & Cell Biology, Boston University 700 Albany Street. Room # 216 Boston, MA 02118, USA Phone: 617-638-4004 Email: manish.bais@bu.edu Darrell J. Irvine, PhD ProfessorofMaterials Science & Engineering and Biological Engineering, MIT Koch Institute for Integrative Cancer Research at MIT Room76-261 Phone (617) 452-4174 Email: djirvine@mit.edu Serge Dibart, DDS, DMD. Chair of Periodontology, Director of the Advanced Specialty Education Program in Periodontics at GSDM, Professor, Department of Periodontology 100 East Newton Street Boston, MA 02118, USA Phone: 617-638-4762 Email: sdibart@bu.edu
  10. 10. Celal Artunc, PhD. Dean and ProfessorofDental Medicine, Ege Univesity Schoolof Dental Medicine Ege University, EU Bornova Izmir 35040, TURKEY. Phone: 90 232 388- 6432 ext: 2801-102. E-mail: celal.artunc@ege.edu.tr JeffreyW. Hutter, BS, DMD, MEd Dean and Spencer N. Frankl Professorin Dental Medicine, Dean’s Office (G-317), Boston University Schoolof Dental Medicine, 100 East Newton Street, Boston MA 02118 USA Phone: 617-638-4780 Email: jhutter@bu.edu David E. Levin, Ph.D. Professorand Chair of Molecular and Cell Biology, BUGSDM ProfessorofMicrobiology 72 East Concord Street, E430 Phone: 617-414-1057 Email: delevin@bu.edu Gary Jay Brenner, M.D., PH.D. Associate Professorof Anesthesia, Massachusetts General Hospital MGH Center for Pain Medicine, WAC 334, 15 Parkman Street Boston MA 02114 Phone: 617/726-9223 Email: gjbrenner@partners.org

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