‫بسم ا الرحمن الرحيم‬

GENUS: YERSINIA
Prof. Khalifa Sifaw Ghenghesh
Yersinia pestis


Plague



Infected Fleas (Xenopsylla cheopis)
are the Major Mechanism of
Transmission.



Rodents >>
Clinical Syndromes
i. Bubonic Plague:






Incubation period:
– < 7 days after flea bite.
High fever and painful bubo ...
ii. Pneumonic Plague:


Bubonic Disease >Pneumonic Plague >
Exhales the Organism in Droplets.



Highly infectious
Incub...
Yersinia pestis

Puss from bubo/Gram-negative rods
LABORATORY DIAGNOSIS



Aspirate from Buboes,
Pus from the Area of Flea Bite,
Sputum, Throat Swab or Blood.



Transport...
Yersinia pestis on Sheep Blood Agar (72hrs)
TREATMENT
– Streptomycin

CONTROL
–A Quarantinable Disease.
– Control of Urban Plague:
– Garbage Disposal.



Y. enterocolitica
Y. pseudotuberculosis
– Enterocolitis:
 Diarrhea,

fever and abdominal pain
 Infection can mimic ...



Y. enterocolitica
Y. pseudotuberculosis
– Enterocolitis:
 Diarrhea,

fever and abdominal pain
 Infection can mimic ...
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Lecture 18 Yersinia

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Lecture 18 Yersinia

  1. 1. ‫بسم ا الرحمن الرحيم‬ GENUS: YERSINIA Prof. Khalifa Sifaw Ghenghesh
  2. 2. Yersinia pestis  Plague  Infected Fleas (Xenopsylla cheopis) are the Major Mechanism of Transmission.  Rodents >>
  3. 3. Clinical Syndromes i. Bubonic Plague:    Incubation period: – < 7 days after flea bite. High fever and painful bubo in the groin and axilla. Untreated Bacteremia > 75% mortality rate
  4. 4. ii. Pneumonic Plague:  Bubonic Disease >Pneumonic Plague > Exhales the Organism in Droplets.  Highly infectious Incubation period: – 2 to 3 days, with fever and malaise – pulmonary signs within one day Untreated > 90% mortality rate  
  5. 5. Yersinia pestis Puss from bubo/Gram-negative rods
  6. 6. LABORATORY DIAGNOSIS  Aspirate from Buboes, Pus from the Area of Flea Bite, Sputum, Throat Swab or Blood.  Transport Media >>  
  7. 7. Yersinia pestis on Sheep Blood Agar (72hrs)
  8. 8. TREATMENT – Streptomycin CONTROL –A Quarantinable Disease. – Control of Urban Plague: – Garbage Disposal.
  9. 9.   Y. enterocolitica Y. pseudotuberculosis – Enterocolitis:  Diarrhea, fever and abdominal pain  Infection can mimic acute appendicitis  More common in children – Other infections:  Septicemia, arthritis, hepatitis, and osteomyelitis – Epidemic outbreaks due to Y. enterocolitica:  Contaminated meat and milk
  10. 10.   Y. enterocolitica Y. pseudotuberculosis – Enterocolitis:  Diarrhea, fever and abdominal pain  Infection can mimic acute appendicitis  More common in children – Other infections:  Septicemia, arthritis, hepatitis, and osteomyelitis – Epidemic outbreaks due to Y. enterocolitica:  Contaminated meat and milk

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