SlideShare a Scribd company logo

Antigen processing and presentation

Antigen processing and presentation by Dr K.Geetha, Associate Professor, Department of Biotechnology, Kamaraj College of Engineering & Technology, Near Virudhunagar, Madurai Dist.

Antigen processing and presentation

1 of 24
Download to read offline
Antigen Processing and
Presentation
Unit I
BT6602
1
Antigen processing and presentation
• Why is it needed?
• How does it happen?
• How are the pathways of endogenous and
exogenous antigen kept apart?
• What are the consequences?
2
T cell receptor: antigen receptor of T cells
Cannot recognise antigen in solution
Must have the antigen processed
and presented to it
Specialised molecules present
antigens to T cells:
MHC molecules
3
Antigen presentation cells required
4
T-Cell receptor
Antigen
MHC
5
MHC
6
Ad

Recommended

Antigen processing and presentation
Antigen processing and presentationAntigen processing and presentation
Antigen processing and presentationRajpal Choudhary
 
MHC MOLECULES
MHC MOLECULESMHC MOLECULES
MHC MOLECULESpreeti337
 
Major Histocompatibility complex & Antigen Presentation and Processing
Major Histocompatibility complex & Antigen Presentation and ProcessingMajor Histocompatibility complex & Antigen Presentation and Processing
Major Histocompatibility complex & Antigen Presentation and ProcessingSreeraj Thamban
 
T CELL ACTIVATION AND IT'S TERMINATION
T CELL ACTIVATION AND IT'S TERMINATIONT CELL ACTIVATION AND IT'S TERMINATION
T CELL ACTIVATION AND IT'S TERMINATIONpremvarma064
 
Immunologic tolerance
Immunologic toleranceImmunologic tolerance
Immunologic toleranceRobin Gulati
 

More Related Content

What's hot

Clonal selection theory
Clonal selection theoryClonal selection theory
Clonal selection theoryVipin Shukla
 
Natural killer cells
Natural killer cellsNatural killer cells
Natural killer cellsKanchan Rawat
 
clonal selection theory.PPTX
clonal selection theory.PPTXclonal selection theory.PPTX
clonal selection theory.PPTXakshyhari
 
Humoral immune response
Humoral immune responseHumoral immune response
Humoral immune responsesufihannan
 
Transplantation immunology
Transplantation immunologyTransplantation immunology
Transplantation immunologyRinkesh Joshi
 
Innate and adaptive immunity
Innate and adaptive immunityInnate and adaptive immunity
Innate and adaptive immunityIkenna Godwin
 
T Cell and its differentiation
T Cell and its differentiationT Cell and its differentiation
T Cell and its differentiationKrishna Moorthy
 
Antigen processing & presentation
Antigen processing & presentationAntigen processing & presentation
Antigen processing & presentationDr Alok Tripathi
 
Antibody class switch ppt
Antibody class switch pptAntibody class switch ppt
Antibody class switch pptCHARLIE
 
2 antigens, immunogens, epitopes, and haptens
2 antigens, immunogens, epitopes, and haptens2 antigens, immunogens, epitopes, and haptens
2 antigens, immunogens, epitopes, and haptenstaha244ali
 
Activation of T and B Cells
Activation of T and B CellsActivation of T and B Cells
Activation of T and B CellsAmbika Prajapati
 
Antigen processing and presentation
Antigen processing and presentationAntigen processing and presentation
Antigen processing and presentationSonika s chauhan
 
Lecture on Antigen processing and presentation pathways
Lecture on Antigen processing and presentation pathwaysLecture on Antigen processing and presentation pathways
Lecture on Antigen processing and presentation pathwaysKristu Jayanti College
 

What's hot (20)

Cytokines
CytokinesCytokines
Cytokines
 
Mhc
MhcMhc
Mhc
 
Clonal selection theory
Clonal selection theoryClonal selection theory
Clonal selection theory
 
Natural killer cells
Natural killer cellsNatural killer cells
Natural killer cells
 
Tumor immunology
Tumor immunologyTumor immunology
Tumor immunology
 
clonal selection theory.PPTX
clonal selection theory.PPTXclonal selection theory.PPTX
clonal selection theory.PPTX
 
Humoral immune response
Humoral immune responseHumoral immune response
Humoral immune response
 
Transplantation immunology
Transplantation immunologyTransplantation immunology
Transplantation immunology
 
Innate and adaptive immunity
Innate and adaptive immunityInnate and adaptive immunity
Innate and adaptive immunity
 
T Cell and its differentiation
T Cell and its differentiationT Cell and its differentiation
T Cell and its differentiation
 
Antibody diversity
Antibody diversityAntibody diversity
Antibody diversity
 
Antigen processing & presentation
Antigen processing & presentationAntigen processing & presentation
Antigen processing & presentation
 
Antibody class switch ppt
Antibody class switch pptAntibody class switch ppt
Antibody class switch ppt
 
2 antigens, immunogens, epitopes, and haptens
2 antigens, immunogens, epitopes, and haptens2 antigens, immunogens, epitopes, and haptens
2 antigens, immunogens, epitopes, and haptens
 
Activation of T and B Cells
Activation of T and B CellsActivation of T and B Cells
Activation of T and B Cells
 
Tcr
TcrTcr
Tcr
 
Antigen processing and presentation
Antigen processing and presentationAntigen processing and presentation
Antigen processing and presentation
 
B cell(Immunology)
B cell(Immunology)B cell(Immunology)
B cell(Immunology)
 
BCR
BCR BCR
BCR
 
Lecture on Antigen processing and presentation pathways
Lecture on Antigen processing and presentation pathwaysLecture on Antigen processing and presentation pathways
Lecture on Antigen processing and presentation pathways
 

Similar to Antigen processing and presentation

Antigen processing and MHC
Antigen processing and MHCAntigen processing and MHC
Antigen processing and MHCKayeen Vadakkan
 
Antigen processing and presentation manu
Antigen processing and presentation manuAntigen processing and presentation manu
Antigen processing and presentation manuManpreetKaur1629
 
Exogenous Antigen Presentation and Processing.pptx
Exogenous Antigen Presentation and Processing.pptxExogenous Antigen Presentation and Processing.pptx
Exogenous Antigen Presentation and Processing.pptxJanani Balamurugan
 
MHC lecture.pptx
MHC lecture.pptxMHC lecture.pptx
MHC lecture.pptxBinteHawah1
 
Antigen Presentation Pathways.pptx
Antigen Presentation Pathways.pptxAntigen Presentation Pathways.pptx
Antigen Presentation Pathways.pptxFareed82
 
Lect 2 cells of immune system rmc 2016
Lect 2 cells of immune system rmc 2016Lect 2 cells of immune system rmc 2016
Lect 2 cells of immune system rmc 2016Hassan Ahmad
 
A Short Note on MHC Molecules
A Short Note on MHC MoleculesA Short Note on MHC Molecules
A Short Note on MHC Moleculesrasel_khan
 
Antigen processing and presentation
Antigen processing and presentationAntigen processing and presentation
Antigen processing and presentationapurvaanand08
 
Antigen processing lecture-nkn
Antigen processing  lecture-nknAntigen processing  lecture-nkn
Antigen processing lecture-nknNavreet Nanda
 
ANTIGEN PRESENTING CELL
ANTIGEN PRESENTING CELLANTIGEN PRESENTING CELL
ANTIGEN PRESENTING CELLDr Sreelakshmi
 
IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...
IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...
IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...StarletMG
 
MAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.ppt
MAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.pptMAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.ppt
MAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.pptPranzly Rajput
 
Major histocompatibility complex
Major histocompatibility complexMajor histocompatibility complex
Major histocompatibility complexSumathi Arumugam
 
Immunology lectures 6.pptx
Immunology lectures 6.pptxImmunology lectures 6.pptx
Immunology lectures 6.pptxAbdiqaniMahamed1
 
12 cellular basis of imune response
12 cellular basis of imune response12 cellular basis of imune response
12 cellular basis of imune responseDr UAK
 

Similar to Antigen processing and presentation (20)

Antigen processing and MHC
Antigen processing and MHCAntigen processing and MHC
Antigen processing and MHC
 
Antigen processing and presentation manu
Antigen processing and presentation manuAntigen processing and presentation manu
Antigen processing and presentation manu
 
Exogenous Antigen Presentation and Processing.pptx
Exogenous Antigen Presentation and Processing.pptxExogenous Antigen Presentation and Processing.pptx
Exogenous Antigen Presentation and Processing.pptx
 
MHC lecture.pptx
MHC lecture.pptxMHC lecture.pptx
MHC lecture.pptx
 
Antigen Presentation Pathways.pptx
Antigen Presentation Pathways.pptxAntigen Presentation Pathways.pptx
Antigen Presentation Pathways.pptx
 
Lect 2 cells of immune system rmc 2016
Lect 2 cells of immune system rmc 2016Lect 2 cells of immune system rmc 2016
Lect 2 cells of immune system rmc 2016
 
A Short Note on MHC Molecules
A Short Note on MHC MoleculesA Short Note on MHC Molecules
A Short Note on MHC Molecules
 
Antigen processing and presentation
Antigen processing and presentationAntigen processing and presentation
Antigen processing and presentation
 
Antigen processing lecture-nkn
Antigen processing  lecture-nknAntigen processing  lecture-nkn
Antigen processing lecture-nkn
 
5. MHC.ppt
5. MHC.ppt5. MHC.ppt
5. MHC.ppt
 
ANTIGEN PRESENTING CELL
ANTIGEN PRESENTING CELLANTIGEN PRESENTING CELL
ANTIGEN PRESENTING CELL
 
IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...
IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...
IGNTU-eContent-392458762550-B.Sc-Biotechnology-4-Dr.PrashantKumarSingh-IMMUNO...
 
MAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.ppt
MAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.pptMAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.ppt
MAJOR HISTOCOMPATIBILITY COMPLEX by Pranzly.ppt
 
Major histocompatibility complex
Major histocompatibility complexMajor histocompatibility complex
Major histocompatibility complex
 
MHC.pptx
MHC.pptxMHC.pptx
MHC.pptx
 
MHC.pptx
MHC.pptxMHC.pptx
MHC.pptx
 
Immunology lectures 6.pptx
Immunology lectures 6.pptxImmunology lectures 6.pptx
Immunology lectures 6.pptx
 
Immune response
Immune responseImmune response
Immune response
 
adaptive immunity
adaptive immunityadaptive immunity
adaptive immunity
 
12 cellular basis of imune response
12 cellular basis of imune response12 cellular basis of imune response
12 cellular basis of imune response
 

More from Kamaraj College of Engineering & Technology, Virudhunagar

More from Kamaraj College of Engineering & Technology, Virudhunagar (20)

Reproduction & Life cycle of micro and macro algae
Reproduction & Life cycle of micro and macro algaeReproduction & Life cycle of micro and macro algae
Reproduction & Life cycle of micro and macro algae
 
Isolation and characterization, Culture Media & Harvesting of Algae
Isolation and characterization, Culture Media & Harvesting of AlgaeIsolation and characterization, Culture Media & Harvesting of Algae
Isolation and characterization, Culture Media & Harvesting of Algae
 
Growth curve and Measurement of algal growth
Growth curve and Measurement of algal growthGrowth curve and Measurement of algal growth
Growth curve and Measurement of algal growth
 
Chemical Composition of micro and macro Algae
Chemical Composition of micro and macro AlgaeChemical Composition of micro and macro Algae
Chemical Composition of micro and macro Algae
 
Structure of micro and macro algal cells
Structure of micro and macro algal cellsStructure of micro and macro algal cells
Structure of micro and macro algal cells
 
Sampling methodology of micro and macro algae
Sampling methodology of micro and macro algaeSampling methodology of micro and macro algae
Sampling methodology of micro and macro algae
 
Introduction to Algae and its classification
Introduction to Algae and its classificationIntroduction to Algae and its classification
Introduction to Algae and its classification
 
Distribution of Economically Important Algae in India
Distribution of Economically Important Algae in IndiaDistribution of Economically Important Algae in India
Distribution of Economically Important Algae in India
 
Conservation of micro and macro algal species
Conservation of micro and macro algal speciesConservation of micro and macro algal species
Conservation of micro and macro algal species
 
Taxonomic identification of micro and macro algae
Taxonomic identification of micro and macro algaeTaxonomic identification of micro and macro algae
Taxonomic identification of micro and macro algae
 
Restriction-Modification system, Types of Restriction enzymes
Restriction-Modification system, Types of Restriction enzymesRestriction-Modification system, Types of Restriction enzymes
Restriction-Modification system, Types of Restriction enzymes
 
Ultrasonics, high pressure, fermentation
Ultrasonics, high pressure, fermentation Ultrasonics, high pressure, fermentation
Ultrasonics, high pressure, fermentation
 
Super critical technology for preservation
Super critical technology for preservation Super critical technology for preservation
Super critical technology for preservation
 
Hurdle technology
Hurdle technology Hurdle technology
Hurdle technology
 
Chemical preservatives, preservation by ionizing radiations
Chemical preservatives, preservation by ionizing radiations Chemical preservatives, preservation by ionizing radiations
Chemical preservatives, preservation by ionizing radiations
 
Calculation of refrigeration load
Calculation of refrigeration load Calculation of refrigeration load
Calculation of refrigeration load
 
Rate of drying for food products
Rate of drying for food products Rate of drying for food products
Rate of drying for food products
 
Properties of air water mixtures
Properties of air water mixturesProperties of air water mixtures
Properties of air water mixtures
 
Freezing and cold storage
Freezing and cold storage Freezing and cold storage
Freezing and cold storage
 
Freeze concentration
Freeze concentration Freeze concentration
Freeze concentration
 

Recently uploaded

The Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati RoyThe Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati RoyTrushali Dodiya
 
Cardiovascular Pathophysiology- Hypertension
Cardiovascular Pathophysiology- HypertensionCardiovascular Pathophysiology- Hypertension
Cardiovascular Pathophysiology- HypertensionVISHALJADHAV100
 
Different types of animal Tissues DMLT .pptx
Different types of animal Tissues DMLT .pptxDifferent types of animal Tissues DMLT .pptx
Different types of animal Tissues DMLT .pptxPunamSahoo3
 
UniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tourUniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tourUSC_Library
 
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...Nguyen Thanh Tu Collection
 
HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)
HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)
HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)Rabiya Husain
 
Detailed Presentation on Human Rights(1).pptx
Detailed Presentation on Human Rights(1).pptxDetailed Presentation on Human Rights(1).pptx
Detailed Presentation on Human Rights(1).pptxDrOsiaMajeed
 
Grantseeking Solo- Securing Awards with Limited Staff PDF.pdf
Grantseeking Solo- Securing Awards with Limited Staff  PDF.pdfGrantseeking Solo- Securing Awards with Limited Staff  PDF.pdf
Grantseeking Solo- Securing Awards with Limited Staff PDF.pdfTechSoup
 
2.15.24 The Birmingham Campaign and MLK.pptx
2.15.24 The Birmingham Campaign and MLK.pptx2.15.24 The Birmingham Campaign and MLK.pptx
2.15.24 The Birmingham Campaign and MLK.pptxMaryPotorti1
 
Practical Research 1: Qualitative Research and Its Importance in Daily Life.pptx
Practical Research 1: Qualitative Research and Its Importance in Daily Life.pptxPractical Research 1: Qualitative Research and Its Importance in Daily Life.pptx
Practical Research 1: Qualitative Research and Its Importance in Daily Life.pptxKatherine Villaluna
 
BTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic LeukemiaBTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic LeukemiaFaheema Hasan
 
Kochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment Model
Kochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment ModelKochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment Model
Kochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment Modelsandeepmenon62
 
Appendicular SkeletonSystem PPT.....pptx
Appendicular SkeletonSystem PPT.....pptxAppendicular SkeletonSystem PPT.....pptx
Appendicular SkeletonSystem PPT.....pptxRenuka N Sunagad
 
Narrative Exploration of New Categories at Mondelēz
Narrative Exploration of New Categories at MondelēzNarrative Exploration of New Categories at Mondelēz
Narrative Exploration of New Categories at MondelēzRay Poynter
 
Chromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-PrincipleChromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-Principleblessipriyanka
 
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptxCONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptxAnupkumar Sharma
 
2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptx2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptxMaryPotorti1
 
The Institutional Origins of Canada’s Telecommunications Mosaic
The Institutional Origins of Canada’s Telecommunications MosaicThe Institutional Origins of Canada’s Telecommunications Mosaic
The Institutional Origins of Canada’s Telecommunications MosaicUniversity of Canberra
 
LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)
LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)
LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)satyanshp7890
 

Recently uploaded (20)

The Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati RoyThe Ministry of Utmost Happiness by Arundhati Roy
The Ministry of Utmost Happiness by Arundhati Roy
 
Cardiovascular Pathophysiology- Hypertension
Cardiovascular Pathophysiology- HypertensionCardiovascular Pathophysiology- Hypertension
Cardiovascular Pathophysiology- Hypertension
 
Different types of animal Tissues DMLT .pptx
Different types of animal Tissues DMLT .pptxDifferent types of animal Tissues DMLT .pptx
Different types of animal Tissues DMLT .pptx
 
UniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tourUniSC Moreton Bay Library self-guided tour
UniSC Moreton Bay Library self-guided tour
 
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
50 ĐỀ THI THỬ TỐT NGHIỆP THPT TIẾNG ANH 2024 CÓ GIẢI CHI TIẾT - GIỚI HẠN KHO...
 
HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)
HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)
HOW TO DEVELOP A RESEARCH PROPOSAL (FOR RESEARCH SCHOLARS)
 
Detailed Presentation on Human Rights(1).pptx
Detailed Presentation on Human Rights(1).pptxDetailed Presentation on Human Rights(1).pptx
Detailed Presentation on Human Rights(1).pptx
 
Grantseeking Solo- Securing Awards with Limited Staff PDF.pdf
Grantseeking Solo- Securing Awards with Limited Staff  PDF.pdfGrantseeking Solo- Securing Awards with Limited Staff  PDF.pdf
Grantseeking Solo- Securing Awards with Limited Staff PDF.pdf
 
2.15.24 The Birmingham Campaign and MLK.pptx
2.15.24 The Birmingham Campaign and MLK.pptx2.15.24 The Birmingham Campaign and MLK.pptx
2.15.24 The Birmingham Campaign and MLK.pptx
 
Practical Research 1: Qualitative Research and Its Importance in Daily Life.pptx
Practical Research 1: Qualitative Research and Its Importance in Daily Life.pptxPractical Research 1: Qualitative Research and Its Importance in Daily Life.pptx
Practical Research 1: Qualitative Research and Its Importance in Daily Life.pptx
 
BTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic LeukemiaBTKi in Treatment Of Chronic Lymphocytic Leukemia
BTKi in Treatment Of Chronic Lymphocytic Leukemia
 
Kochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment Model
Kochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment ModelKochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment Model
Kochi Mulesoft Meetup # 17 - RTF on OpenShift Deployment Model
 
Appendicular SkeletonSystem PPT.....pptx
Appendicular SkeletonSystem PPT.....pptxAppendicular SkeletonSystem PPT.....pptx
Appendicular SkeletonSystem PPT.....pptx
 
Narrative Exploration of New Categories at Mondelēz
Narrative Exploration of New Categories at MondelēzNarrative Exploration of New Categories at Mondelēz
Narrative Exploration of New Categories at Mondelēz
 
Chromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-PrincipleChromatography-Gas chromatography-Principle
Chromatography-Gas chromatography-Principle
 
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptxCONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
CONCEPTS OF ENVIRONMENT & ECOSYSTEM.pptx
 
Time-Honored Wisdom: African Teachings for VUCA Leaders
Time-Honored Wisdom: African Teachings for VUCA LeadersTime-Honored Wisdom: African Teachings for VUCA Leaders
Time-Honored Wisdom: African Teachings for VUCA Leaders
 
2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptx2.15.24 Making Whiteness -- Baldwin.pptx
2.15.24 Making Whiteness -- Baldwin.pptx
 
The Institutional Origins of Canada’s Telecommunications Mosaic
The Institutional Origins of Canada’s Telecommunications MosaicThe Institutional Origins of Canada’s Telecommunications Mosaic
The Institutional Origins of Canada’s Telecommunications Mosaic
 
LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)
LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)
LIGHT,MIRROR,REFLECTION& REFRACTION. (Optometric optics)
 

Antigen processing and presentation

  • 2. Antigen processing and presentation • Why is it needed? • How does it happen? • How are the pathways of endogenous and exogenous antigen kept apart? • What are the consequences? 2
  • 3. T cell receptor: antigen receptor of T cells Cannot recognise antigen in solution Must have the antigen processed and presented to it Specialised molecules present antigens to T cells: MHC molecules 3
  • 7. 7
  • 8. Antigen Processing and Presentation • Ag recognition by T cells REQUIRES presentation by MHC on a cell membrane (MHC restriction) • Pathways for Ag presentation: a) Class I MHC associated with peptides from endogenous Ag b) Class II MHC associated with peptides from exogenous Ag 8
  • 9. Type of T cell activated • MHC class I activate CD8 T cytotoxic cells • Present endogenous (eg viral) antigens • Target cell is killed by CD8 cell • Any cell can become virally infected/neoplastic • Therefore: MHC class I is on all nucleated cells 9
  • 10. Type of T cell activated • MHC class II activate CD4 T helper cells • Present exogenous (eg bacteria) antigens • CD4 T cells upregulate all immune functions • MHC class II found only on cells that sample the extracellular environment 10
  • 11. A question of language • Cells that express MHC class I, present endogenous ag – Are killed by CD8+ cells – Are called Target cells • Cells that express MHC class II, present exogenous ag – Activate the CD4 T cell response – Are called Antigen presenting cells
  • 12. • Target cells: – All nucleated cells express MHC class I – Can be a target cell if virally infected/neoplastic • Antigen presenting cells – Limited number of cells express MHC class II – Must sample extracellular environment – Monocytes, MΦ, B cells
  • 13. Distinctions between MHC I and MHC II • Most cells (target cells) can present Ag with MHC I to TC’s • Nearly all nucleated cells infected by MO/virus, or abnormal proteins produced by cancer cells, aging cells, or by allogeneic cells from transplants • Associated with MHC I requires replication of foreign entity (i.e., abnormal protein synthesis) within the target cell • Only APC’s can present Ag with MHC II to TH’s • APC’s are of 2 categories: – Professional APC’s – Non-professional APC’s • Associated with MHC II does not require replication of entity with in target cells • Phagocytosis is important in Ag- processing MHC I MHC II MHC 13
  • 14. Ag is processed through 2 separate pathways: *MHC I interacts with peptides from cytosolic degradation *MHC II interacts with peptides from endocytic degradation 14
  • 15. Processing Endogenous Ag: Cytosolic pathway • Cellular components of proteins are constantly regulated; most have a brief half-life and are “turned over”… the same holds true for endogenous Ag’s! • Processing of endogenous Ag involves 3 activities: • Peptide generation from proteolysis • Transport to ER • Peptide binding to MHC I 15
  • 16. Endogenous Ag processing… Peptide generation • Proteins targeted for lysis combine with a small protein  ubiquitin • Ubiquitin-protein complex is degraded by a proteosome • Specific proteosomes generate peptides which can bind to MHC I 16
  • 17. Endogenous Ag processing… Transport to ER • Peptides from proteolysis bind to a “transporter protein associated with Ag processing” (TAP) • TAP is a heterodimer which uses ATP to help transport peptides (8- 10 aa’s) to lumen of ER • Usually basic amino acids at COOH end of peptide chain. 17
  • 18. • MHC I assembly occurs with the aid of chaperone proteins to promote folding (calnexin + MHC I α chain) • Tapasin + calreticulin brings TAP/ peptide close to MHC assembly • Allows MHC I to bind to peptides • MHC I-Ag exits ER to Golgi to plasma membrane Endogenous Ag processing… Peptide binding to MHC I 18
  • 19. Assembly and stabilization of MHC I – Ag complex 19
  • 20. Processing of Exogenous Ag’s: Endocytic pathway • Exogenous Ag’s are typically phagocytized/ endocytized by MØ and APC’s – Foreign Ag is degraded with in endocytic vacuole of endocytic pathway. The pathway includes: – Early endosomes (pH 6-6.5) – Late endosomes or endolysosome (pH 5-6) – Lysomes (pH 4.5 – 5) • Ag is degraded into 13-18 aa polypeptides which bind to MHC II • Eventually endocytic vacuole returns to PM  recycling surface receptors 20
  • 21. Processing of Exogenous Ag’s: Endocytic pathway 21
  • 22. Processing of Exogenous Ag’s: Manufacture of MHC II • With in ER, α and β chains of MHC II combine with a protein – “the invariant chain” (Ii, CD74) • The IC binds to MHC at peptide binding cleft & then exits the ER to Golgi apparatus. • As proteolytic activity continues, the IC is degraded to a small fragment (CLIP*) • Another MHC II (HLA-DM (found in endosomes)) substitutes Ag for CLIP with in lysosome • MHC II – Ag complex is transported to the PM *CLIP = class II associated invariant chain peptide 22