Successfully reported this slideshow.
You’ve unlocked unlimited downloads on SlideShare!
Alcoholism ,wernicke's encephalopathy and the social factors
Alcohol and Wernicke’s
A public health perspective
Dr Gargi Sinha MBBS(LHMC,New Delhi),Grad Dip Public Health(Edith Cowan University Australia)
Dr Nilotpal Das FRANZCP,MD(AIIMS,New Delhi),DNB
What is Wernicke’s encephalopathy
Wernicke’s encephalopathy is an
acute neuropsychiatric syndrome
resulting from thiamine
The condition can arise in many
clinical settings including chronic
alcohol abuse, malnutrition,
procedures, recurrent vomiting,
chronic diarrhoea, chemotherapy,
malnutrition and starvation.
What are the social factors associated with
Oral thiamine is generally of no benefit
Thiamine should be given early, as soon as the condition is suspected.
How much thiamine?
Although there are no consensus
guidelines, most common
practice is to provide 500 mg of
thiamine hydrochloride in 100 ml
of normal saline, given by
infusion, over a period of 30
minutes, three times per day, for
2-3 days. After this, thiamine
hydrochloride is continued at a
dose of 250 mg IV, once a day for
Why thiamine before carbohydrate?
It is mandatory that thiamine is
given before any carbohydrate
challenge in the
presence of severe