Evolution of Compound Management  Systems in an Academic Environment   Gregory J. Wendel, Ph.D. The Siegel Consulting Grou...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Broad Institute: a permanent biomedical research organization <ul><li>Eli and Edythe L. Broad, in partnership with Harvard...
Broad Platforms   The Broad's Scientific platforms are made up of professional scientists with the expertise and organizat...
The Broad Institute Chemical Biology Platform 1998 2011 2004 2008 Screening at Institute of Chemistry and Cellular Biology...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Compound Collection: 2007 <ul><li>Commercial libraries </li></ul><ul><li>Purchased from ChemDiv, ChemBridge, Life, etc., t...
<ul><li>90K compound collection in low volume, stored in 384 and 96 well plates and vials with no routine QC.  </li></ul><...
Retest Cherry picks - 2008 <ul><li>Manual retrieval of stock plates from freezer </li></ul><ul><li>Thaw and unseal entire ...
Compound  Registration Process – 2008-2009 Jira Chemist submits Compound (s) Compound in vial Verify contents,  Export SDF...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Change in the Scope of the Screening Center NCI Initiative for Chemical Genetics NIH MLPCN Comprehensive Screening Center ...
Roadmap to Evolution: Principles <ul><li>“ We became used to inefficiency to such a degree that we accepted it as the norm...
Roadmap to Evolution <ul><li>Determine current holdings </li></ul><ul><li>Purity determination for all compounds </li></ul...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Roadmap: Determine current holdings <ul><li>Reformatting </li></ul><ul><li>All compounds moved from deep-well storage to M...
Summary of Compound QC (DOS + Legacy) Collection Total number of compounds Total number of compounds passing QC (>75% puri...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Roadmap: Automated solutions for processes <ul><li>Requirement gathering </li></ul><ul><li>Random access to all compounds ...
Collaboration with HighRes BioSolutions <ul><li>Compound Storage, Replication, and Reformatting </li></ul><ul><li>Long-ter...
Automation Integration In collaboration with HighRes BioSolutions ~2400 sq. ft Long-term compound store Compound managemen...
Long-term Compound Storage System Nexus Universal Labstore AI Module for tube delivery Tube Selector IO Station HighRes Mi...
Long-term Compound Storage System <ul><li>HighRes integration of Nexus BioSystems Universal Labstore (automated freezer) w...
Compound Management System BL2 BL2+ General Screening Photo credit: HighRes BioSolutions
Compound Management System <ul><li>HighRes BioSolutions 9-sided MicroStar™ integration with a Nexus Universal Labstore, St...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Roadmap:  Workflow Standardization <ul><li>Procedure: </li></ul><ul><li>Detail what is currently being done </li></ul><ul>...
Roadmap:  Workflow Standardization <ul><li>Standard Processes: </li></ul><ul><li>Registration </li></ul><ul><li>Compound i...
Revised Compound Registration Process Time Line 1.7 Man-Hour  (Registration) 10 Day duration (Avg) Chemist submits Compoun...
Retest Cherry picks - 2010 <ul><li>Working with end users, defined small set of preferred layouts. </li></ul><ul><li>Creat...
Retest Cherry picks - 2010 <ul><li>Order created with informatic system </li></ul><ul><li>Mother tubes cherry picked from ...
Impact of new processes <ul><li>Decreased turn around time to 1 week or less </li></ul><ul><li>Eliminate un-necessary free...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Collection Enhancement <ul><li>Computational Chemistry </li></ul><ul><li>Maximize diversity chemical structures described ...
Broad Chemical Biology: DOS Synthesize diverse small molecules having structural complexity rivaling naturally occurring s...
Broad Chemical Biology Compound Collection <ul><li>Complexity </li></ul>Natural Product (Rapamycin) Great complexity 78 Ch...
A Build/Couple/Pair (B/C/P) strategy for DOS Nielsen T.E.; Schreiber, S.L.  Angew. Chem. Int. Ed .  2008 ,  47 ,48-56
2008: New Compound Collection
Chemical Biology screening collection Broad (~102K) MLPCN (~324K) MLPCN Library Properties: Purity > 90% (vendor specified...
Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 ...
Expanding the reach <ul><li>CM has capabilities that are of  value to other programs within  the Broad </li></ul><ul><ul><...
Summary <ul><li>Academic screening labs engender diversity </li></ul><ul><ul><li>Multiple stakeholders each with distinct ...
Acknowlwdgements Lisa Marcaurelle DOS Chemistry Michelle Palmer Josh Bittker Screening Mike Foley Stuart Schreiber Aly Sha...
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Compound Management Focus 2010

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Compound Management Focus 2010

  1. 1. Evolution of Compound Management  Systems in an Academic Environment Gregory J. Wendel, Ph.D. The Siegel Consulting Group, Inc December 7, 2010
  2. 2. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  3. 3. Broad Institute: a permanent biomedical research organization <ul><li>Eli and Edythe L. Broad, in partnership with Harvard and its hospitals, and MIT, founded the Broad Institute in 2003 as a ten-year “experiment” in philanthropy and in collaborative scientific organization with $100 million (later doubled to $200 million) </li></ul><ul><li>The goal of the founders was to test if this model of science combined with “venture philanthropy” could accelerate the transformation of medicine </li></ul><ul><li>Only four years after its launch, the experiment was declared an unqualified success by the Broads, Harvard and MIT </li></ul><ul><li>In recognition of this success, the Broads announced an endowment of $400 million in addition to their previous gifts </li></ul><ul><li>The cross-institutional, interdisciplinary collaborative structure of the Institute has not changed. Endowment makes the Institute a permanent nonprofit organization, with Harvard and MIT continuing to play a major role in its governance </li></ul>
  4. 4. Broad Platforms The Broad's Scientific platforms are made up of professional scientists with the expertise and organization to carry out major projects that cannot be done within a single laboratory Broad Programs The Broad's Scientific programs bring together research groups with a shared commitment to important biomedical challenges Broad Faculty 6 Core Members in Broad buildings 155 Associate Members: faculty with labs at MIT, Harvard, Whitehead, or affiliated hospitals Imaging RNAi Chemical Biology/Novel Therapeutics Proteomics Genetic Analysis Genome Sequencing Biological Samples A unique collaborative structure enables the Broad mission Computational Biology Infectious Disease Chemical Biology Medical & Popul’n Genetics Psychiatric Disease Stanley Center Metabolic Disease Cell Circuits Genome Biology Cancer
  5. 5. The Broad Institute Chemical Biology Platform 1998 2011 2004 2008 Screening at Institute of Chemistry and Cellular Biology (ICCB), Harvard Medical School; Early DOS concepts Broad Institute of Harvard & MIT Automation online; MLPCN comprehensive screening center (BIPDeC); 1 st platform DOS compounds 2007 Automated screening system design (HighRes Biosolutions) 2006 Platform DOS library design 2009 The Broad Institute, Inc. 200k platform DOS compounds online 2002 NCI Initiative for Chemical Genetics
  6. 6. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  7. 7. Compound Collection: 2007 <ul><li>Commercial libraries </li></ul><ul><li>Purchased from ChemDiv, ChemBridge, Life, etc., to support perceived needs. </li></ul><ul><li>Submissions </li></ul><ul><li>Collections of 10’s to 100’s of compounds from researchers, post doc’s, etc. </li></ul><ul><li>Discrete compounds from the community </li></ul><ul><li>Plating </li></ul><ul><li>Done to suit a particular programfocus </li></ul><ul><li>Arcane names for plate maps, selected by researcher </li></ul>
  8. 8. <ul><li>90K compound collection in low volume, stored in 384 and 96 well plates and vials with no routine QC. </li></ul><ul><li>Manual inventory retrieval </li></ul><ul><li>Inventory tracking via Excel </li></ul><ul><li>Exclusively walk up instrumentation </li></ul><ul><li>Manual tracking of liquid handling events </li></ul>Compound Management- Past
  9. 9. Retest Cherry picks - 2008 <ul><li>Manual retrieval of stock plates from freezer </li></ul><ul><li>Thaw and unseal entire plate to gain access to 1 compound. </li></ul><ul><li>Made anything for anyone </li></ul><ul><li>Manual cherry-picking </li></ul><ul><li>Dilution series performed on a liquid handler </li></ul><ul><li>4 – 6 week delay time </li></ul>
  10. 10. Compound Registration Process – 2008-2009 Jira Chemist submits Compound (s) Compound in vial Verify contents, Export SDF Review for issues SDF Normalization Normalized Structure Curated Structure BRD, data Curate Structures Excel file w/ structure, supplier, etc Sample ID Created BRD Created CBIP Pipeline Pilot Human Time Line 1.7 Man-Hour (Registration) 10 Day duration (Avg) Transfer to vial and weigh
  11. 11. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  12. 12. Change in the Scope of the Screening Center NCI Initiative for Chemical Genetics NIH MLPCN Comprehensive Screening Center Extensive Collaboration with Academia Extensive Collaboration with Academia 12 Primary Screens per year 25 Probe Projects per year Walk-up Instrumentation Walk-up & Integrated Automation Primary Screen & Limited Dose Response Dose Response & Secondary Assays ChemBank PubChem Commercial + small-scale internal libraries NIH MLSMR, commercial, legacy, + production-scale internal libraries No routine internal compound QC 100% QC (>75% LC/MS UV 210 )
  13. 13. Roadmap to Evolution: Principles <ul><li>“ We became used to inefficiency to such a degree that we accepted it as the norm. It is only when these inefficiencies are removed that we realize just how great of a burden they’ve been.” </li></ul><ul><li>Steven Spear in Chasing the Rabbit , 2009 </li></ul><ul><li>Goal of redesign </li></ul><ul><li>Remove “work arounds”, “making do”, and coping with a problem </li></ul><ul><li>Evolve the capabilities to support anticipated increases in demand and a broader customer base </li></ul>
  14. 14. Roadmap to Evolution <ul><li>Determine current holdings </li></ul><ul><li>Purity determination for all compounds </li></ul><ul><li>Controlled storage conditions </li></ul><ul><li>Automated solutions for processes </li></ul><ul><li>Automated tube stores </li></ul><ul><li>Robotic systems for tube/plate processing </li></ul><ul><li>Workflow standardization </li></ul><ul><li>Standard plate and retest formats </li></ul><ul><li>Increased efficiency </li></ul><ul><li>Collection enhancement </li></ul><ul><li>Apply computational chemistry to direct compound acquisitions </li></ul>
  15. 15. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  16. 16. Roadmap: Determine current holdings <ul><li>Reformatting </li></ul><ul><li>All compounds moved from deep-well storage to Matrix tubes and vials </li></ul><ul><li>Aliquot taken for QC </li></ul><ul><li>Purity analysis </li></ul><ul><li>LC/MS; 75% purity threshold (UV 210 ) </li></ul><ul><li>80.9% of existing compounds passed </li></ul>
  17. 17. Summary of Compound QC (DOS + Legacy) Collection Total number of compounds Total number of compounds passing QC (>75% purity by UV 210 ) Legacy 56,162 42,794 (76.2%) DOS 63,069 52,819 (83.7%) New commercial 4,931 4,846 (98.3%) Pending DOS 16,804 TBD Pending commercial 17,779 TBD Total completed 124,162 100,459 (80.9%)
  18. 18. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  19. 19. Roadmap: Automated solutions for processes <ul><li>Requirement gathering </li></ul><ul><li>Random access to all compounds </li></ul><ul><li>Be able to produce compound, cherry picks, dose response plates and Assay Ready Plates </li></ul><ul><li>Process compound powder submissions </li></ul><ul><li>Hardware selection </li></ul><ul><li>Hamilton Starlet for most workflows </li></ul><ul><li>Labcyte Echo for ARP’s </li></ul><ul><li>Nexus storage </li></ul><ul><li>HighRes BioSolutions integration </li></ul>
  20. 20. Collaboration with HighRes BioSolutions <ul><li>Compound Storage, Replication, and Reformatting </li></ul><ul><li>Long-term Compound Storage System(LTS) </li></ul><ul><li>Compound Management System (CM) </li></ul><ul><li>High-Throughput Screening </li></ul><ul><li>BL2 Screening System </li></ul><ul><li>BL2+ Screening System </li></ul><ul><li>General Screening System (GS) </li></ul>
  21. 21. Automation Integration In collaboration with HighRes BioSolutions ~2400 sq. ft Long-term compound store Compound management module General screening module BL2 mammalian screening module BL2 bacteria/yeast screening module
  22. 22. Long-term Compound Storage System Nexus Universal Labstore AI Module for tube delivery Tube Selector IO Station HighRes MicroDock Staubli Robotic Arm Cellario PC
  23. 23. Long-term Compound Storage System <ul><li>HighRes integration of Nexus BioSystems Universal Labstore (automated freezer) with a Staubli robotic arm and a HighRes MicroDock™. </li></ul><ul><li>Capacity for a fully QC’d Broad DOS compound library stored as powders in 1.4mL glass tubes at -20 degrees C. </li></ul><ul><li>Nexus Tube Selector reformats tubes into high-density tube racks (952 tubes/ rack) </li></ul><ul><li>2D barcode scanner (on Nexus) and 1D barcode scanner (on HighRes) for sample tracking. </li></ul><ul><li>Freezer capacity ~ 300K glass tubes </li></ul><ul><li>Currently holds 64K DOS compounds and 7031 compounds as dry powders/films in vials </li></ul>
  24. 24. Compound Management System BL2 BL2+ General Screening Photo credit: HighRes BioSolutions
  25. 25. Compound Management System <ul><li>HighRes BioSolutions 9-sided MicroStar™ integration with a Nexus Universal Labstore, Staubli robotic arm, Hamilton Starlets, and other devices. </li></ul><ul><li>Designed for: </li></ul><ul><ul><li>Creation and -20C storage of Mother compounds in plastic Matrix tubes. </li></ul></ul><ul><ul><li>Random access to all wet compound stores </li></ul></ul><ul><ul><li>Creation of Daughter Plates, Retest plates, and Assay Ready plates </li></ul></ul><ul><ul><li>Fully integrated database </li></ul></ul><ul><li>Currently holds 133k mother tubes of compounds in DMSO. </li></ul>Photo credit: HighRes BioSolutions
  26. 26. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  27. 27. Roadmap: Workflow Standardization <ul><li>Procedure: </li></ul><ul><li>Detail what is currently being done </li></ul><ul><li>Look for commonalities </li></ul><ul><li>Reduce to core required workflows </li></ul><ul><li>Design for flexibility to support requirements of various stakeholders </li></ul><ul><li>Design informatic support </li></ul><ul><li>Implement </li></ul><ul><li>Results: </li></ul><ul><li>Predictable response time </li></ul><ul><li>Improved quality </li></ul><ul><li>Resource load leveling </li></ul><ul><li>Increased flexibility </li></ul>
  28. 28. Roadmap: Workflow Standardization <ul><li>Standard Processes: </li></ul><ul><li>Registration </li></ul><ul><li>Compound intake, storage, & solution generation </li></ul><ul><ul><li>Security: sequester compounds as private to specific user or group; prevent unauthorized viewing or requesting </li></ul></ul><ul><li>Screening plate generation: Assay-ready or DMSO </li></ul><ul><li>Cherry picks </li></ul><ul><li>Create standard layouts for screening and retest plates </li></ul><ul><li>Software solutions to better integrate ordering, tracking, and robotics </li></ul><ul><li>Met needs of 95+% of requests </li></ul><ul><li>Impelled non-standard requestors to re-think their experimental design </li></ul>
  29. 29. Revised Compound Registration Process Time Line 1.7 Man-Hour (Registration) 10 Day duration (Avg) Chemist submits Compound(s) Compound in vial Verify contents, Export SDF Review for issues SDF Normalization Normalized Structure Curated Structure BRD, data Curate Structures Excel file w/ structure, supplier, etc Sample ID Created BRD Created CBIP Pipeline Pilot Human Transfer to vial and weigh Chemist has Compound(s) Register via ELN Submit vials to CM Time Line 0.5 Man-Hour (Registration) 0.5 Hour duration (Avg)
  30. 30. Retest Cherry picks - 2010 <ul><li>Working with end users, defined small set of preferred layouts. </li></ul><ul><li>Create template for request submission that asks for all required information </li></ul><ul><li>Linked defined layouts to system workflows and Hamilton methods </li></ul><ul><li>Train all requestors </li></ul><ul><li>Honor delivery time commitment </li></ul>
  31. 31. Retest Cherry picks - 2010 <ul><li>Order created with informatic system </li></ul><ul><li>Mother tubes cherry picked from Nexus Store </li></ul><ul><li>Defined plate layouts </li></ul><ul><li>Dilution series done on Hamilton Starlet </li></ul><ul><li>Plate map recorded in CBIP </li></ul><ul><li>Option to fully automated on HRB system </li></ul><ul><li>1 week processing with increased throughput </li></ul>
  32. 32. Impact of new processes <ul><li>Decreased turn around time to 1 week or less </li></ul><ul><li>Eliminate un-necessary freeze/thaw cycles </li></ul><ul><li>Predictability for screeners </li></ul><ul><li>Increased flexibility for “Special requests” </li></ul>
  33. 33. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  34. 34. Collection Enhancement <ul><li>Computational Chemistry </li></ul><ul><li>Maximize diversity chemical structures described by 2D descriptors </li></ul><ul><li>Used to: </li></ul><ul><ul><li>Maximize diversity of new compound purchases relative to each other and to existing collection </li></ul></ul><ul><ul><li>Maximize diversity of building blocks for use in combinatorial diversification of library cores </li></ul></ul>MaxMin algorithm: Ordering compounds for maximal dissimilarity
  35. 35. Broad Chemical Biology: DOS Synthesize diverse small molecules having structural complexity rivaling naturally occurring small molecules, and having chemical handles that enable systematic optimization or modification (e.g., for making target I.D. reagents, or for adding biasing elements). Process Chemistry Robust and practical synthesis of scaffolds Medicinal Chemistry Built-in SAR Handles for Target ID Structural Diversity Emphasis on stereochemical and skeletal diversity
  36. 36. Broad Chemical Biology Compound Collection <ul><li>Complexity </li></ul>Natural Product (Rapamycin) Great complexity 78 Chemical steps N N O C H 3 C l Drug compound (Valium) Minimal complexity 1 Chemical step M e O M e O M e O H O M e O O N M e O M e M e O M e O O H O H M e H M e N H O M e O M e O M e N O O O H DOS compound Moderate complexity 3 Chemical steps!
  37. 37. A Build/Couple/Pair (B/C/P) strategy for DOS Nielsen T.E.; Schreiber, S.L. Angew. Chem. Int. Ed . 2008 , 47 ,48-56
  38. 38. 2008: New Compound Collection
  39. 39. Chemical Biology screening collection Broad (~102K) MLPCN (~324K) MLPCN Library Properties: Purity > 90% (vendor specified) Availability (10 mg) and re-supply (20 mg) MW ≤ 600 CLogP ≤ 6 Calculated solubility ≥ 20 ug/mL MW vs ALogP Molecular Weight ALogP CVL DOS STRD NATP Code Collection name # of compounds CBLI DOS 61,004 CHRM Chromatin biased 2,327 BIOA Bioactives 4,920 STRD Non-commercial stereochemically diverse 2,115 NATP Natural products - purified 1,291 KINA Kinase biased 12,119 COMA Commercial - Forma 1,133 COMB Commercial - other 12,278 GPCR G protein-coupled receptor biased 5,000     102,187 New code Collection name # of compounds COMB Commercially available 296,780 BIOA Bioactives 442 STRD Non-commercial stereochemically diverse 14,801 NATP Natural products - purified 1,472 GPCR G protein-coupled receptor biased 3,880 IONC Ion channel targeted 1,956 KINA Kinase biased 3,892 NUCR Nuclear receptor targeted 152 PROT Protease targeted 684     324,059
  40. 40. Broad Institute CM: An Automation Evolution <ul><li>Broad Institute overview </li></ul><ul><li>State of the systems: 2007 </li></ul><ul><li>Roadmap to Evolution </li></ul><ul><ul><li>Determine what we have </li></ul></ul><ul><ul><li>Automate processes </li></ul></ul><ul><ul><li>Workflow standardization </li></ul></ul><ul><ul><li>Collection enhancement </li></ul></ul><ul><li>Summary </li></ul>
  41. 41. Expanding the reach <ul><li>CM has capabilities that are of value to other programs within the Broad </li></ul><ul><ul><li>Compound registration and storage </li></ul></ul><ul><ul><li>Plate creation, dose curves </li></ul></ul><ul><ul><li>Assay Ready Plates </li></ul></ul><ul><li>Purchasing, formatting, and storing compounds for Malaria group in Infectious Disease Initiative and the Cancer group </li></ul><ul><li>Creating ARPs, e.g. for BL3 screening </li></ul><ul><li>Supporting MedChem effort in Stanley Center (Psychiatric Disease) </li></ul><ul><li>Managing samples for industry collaborations </li></ul><ul><li>Sharing DOS libraries with collaborators </li></ul>
  42. 42. Summary <ul><li>Academic screening labs engender diversity </li></ul><ul><ul><li>Multiple stakeholders each with distinct needs </li></ul></ul><ul><li>Apply principles of system design </li></ul><ul><ul><li>Detailed requirements </li></ul></ul><ul><ul><li>Forward looking design </li></ul></ul><ul><li>Workflow standardization </li></ul><ul><ul><li>Say what you will do, do what you say </li></ul></ul><ul><li>Rigidity creates flexibility </li></ul>
  43. 43. Acknowlwdgements Lisa Marcaurelle DOS Chemistry Michelle Palmer Josh Bittker Screening Mike Foley Stuart Schreiber Aly Shamji Edward Scolnick Informatics Andrea De Souza Raza Shaikh Paul Clemons Computational Research The Broad Institute – Chemical Biology Platform http://www.broadinstitute.org/scientific-community/science/platforms/chemical-biology Compound Management Sean Collignon Corrie Lade John McGrath HighRes BioSolutions http://www.highresbio.com/ Lou Guarrancina Michael Nichols Vlad Zhirnov Ira Hoffman John Smyka Scott Rehlander Siegel Consulting Group http://www.siegelcg.com Gregory Wendel

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