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PATHOLOGY PRACTICAL
• Introduction 
• „Most common skin cancer arising from the 
basal layer of epidermis and its appendages 
• „ Low metastat...
• Epidemiology 
• „ Skin cancer: approx. 1.5 million cases per year 
• „ BCC is most common skin cancer 80% is BCC 
• „ Wh...
• Clinical presentation 
• A round, nodular, pearly tumour is present 
on the left cheek. 
• The presence of dilated, sub ...
BASAL CELL CARCINOMA
• Macroscopic examination of the slide shows a 
section of skin and underlying subcutaneous 
tissue. 
• Immediately beneat...
• Microscope shows nodular masses of tumour cells 
(1) extending from the epidermis into the underlying 
dermal connective...
• Basal cell carcinomas are believed to arise from 
a pluripotential cell in the basal layer of the 
epidermis which has t...
Psoriasis
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
Practical  .scc,bcc
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Practical .scc,bcc

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Practical .scc,bcc

  1. 1. PATHOLOGY PRACTICAL
  2. 2. • Introduction • „Most common skin cancer arising from the basal layer of epidermis and its appendages • „ Low metastatic potential • „ Locally invasive, aggressive, and destructive to skin and bone
  3. 3. • Epidemiology • „ Skin cancer: approx. 1.5 million cases per year • „ BCC is most common skin cancer 80% is BCC • „ White >> Black • „ Men >> women • „ BCC increase with age • „ Aged 55--70 has 100 fold higher • incidence of BCC than age 20 and younger • „ Striking geographic variation • „ Higher incidence closer to the • equator • „ *Australia is 40X that of Finland 80%
  4. 4. • Clinical presentation • A round, nodular, pearly tumour is present on the left cheek. • The presence of dilated, sub epidermal blood vessels (telangiectasia's) is characteristic of basal cell carcinomas.
  5. 5. BASAL CELL CARCINOMA
  6. 6. • Macroscopic examination of the slide shows a section of skin and underlying subcutaneous tissue. • Immediately beneath and elevating the epidermis is a blue cellular tumour composed of multiple variable sized islands of basophilic tissue • . The margins of the tumour appear smooth and rounded.
  7. 7. • Microscope shows nodular masses of tumour cells (1) extending from the epidermis into the underlying dermal connective tissue and elevating the overlying focally ulcerated epidermis. • The tumour cells have a fairly uniform monotonous appearance - they are spindle in shape with indistinct eosinophilic cytoplasm and oval basophilic nuclei with indistinct nucleoli (2). • A characteristic feature of basal cell carcinoma is the tendency of the cells at the periphery of the tumour nests to become vertically orientated (2) and form a palisaded layer. Frequent mitotic figures are seen and this is also a feature of basal cell carcinoma. •
  8. 8. • Basal cell carcinomas are believed to arise from a pluripotential cell in the basal layer of the epidermis which has the capacity to differentiate into epidermis and any of its adnexal structures. • Thus in basal cell carcinomas one may see evidence of keratinisation, hair follicle formation, or sebaceous differentiation. • These tumours tend to locally infiltrate and ulcerate but rarely metastasise.
  9. 9. Psoriasis

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