Actinomycosis
• A. Israelii – the commonest
• A .Meyeri
• A.Naeslundii
• A.Odontolyticus
• A. Viscosus
Actinomycosis
ACTINOMYCOSIS
Not highly virulent (Opportunist)
– Component of Oral Flora
• Periodontal pockets
• Dental plaque
• Tonsilar...
PEOPLE AT RISK WITH ACTINOMYCOSIS
• Having a dental disease or recent dental surgery (for
jaw abscess)
• Aspiration (liqui...
Cervicofacial Actinomycosis
• This is the most common and recognized
presentation of the disease.
• Actinomyces species ar...
Infection Cervicofacial region
• Periostitis or
osteomyelitis can
develop if the infection
extends to facial and
maxillary...
Abdominal Actinomycosis
Examination of discharges will help in diagnosis
• Examination of drained fluid under a
microscope shows "sulphur granules...
Typical appearance of histopathological
examination with special stains
Dr.T.V.Rao MD 12
• The smears revealed radiating filamentous
colonies of Actinomyces in a background of
neutrophilic exudates;
• PAS stain ...
Mycetoma
• Mycetoma is a chronic subcutaneous
infection caused by actinomycetes or
fungi.
• This infection results in a
gr...
Mycetoma
• Mycetoma is characterized by the
formation of grains containing aggregates
of the causative organisms that may ...
•
• Slow spreading skin infection
• Local swelling
• Small hard painless nodules
• Ulceration
• Pus discharge
• Sinuses
• Sc...
• Direct microscopy:
• Blood- Leukocytosis & neutrophilia
• Culture of exudates
• Skin biopsy
• Serology.
DIAGNOSIS.
Excised mycetoma showing a draining sinus
(cut open in this preparation) containing black grains.
H&E stainskin biopsy
H&E stained tissue section showing blacked grained
eumycotic mycetoma caused by Madurella mycetomatis.
• Granulomatous Inflammation With Abscess
Formation.
• A Central Zone Exists Where Polymorphonuclear
Cells Are Abundant An...
Pathology practical actinomycosis and maduramycosis 22 07-2014.
Pathology practical actinomycosis and maduramycosis 22 07-2014.
Pathology practical actinomycosis and maduramycosis 22 07-2014.
Pathology practical actinomycosis and maduramycosis 22 07-2014.
Pathology practical actinomycosis and maduramycosis 22 07-2014.
Pathology practical actinomycosis and maduramycosis 22 07-2014.
Pathology practical actinomycosis and maduramycosis 22 07-2014.
Pathology practical actinomycosis and maduramycosis 22 07-2014.
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Pathology practical actinomycosis and maduramycosis 22 07-2014.

  1. 1. Actinomycosis
  2. 2. • A. Israelii – the commonest • A .Meyeri • A.Naeslundii • A.Odontolyticus • A. Viscosus Actinomycosis
  3. 3. ACTINOMYCOSIS Not highly virulent (Opportunist) – Component of Oral Flora • Periodontal pockets • Dental plaque • Tonsilar crypts – Take advantage of injury to penetrate mucosal barriers • Coincident infection • Trauma • Surgery
  4. 4. PEOPLE AT RISK WITH ACTINOMYCOSIS • Having a dental disease or recent dental surgery (for jaw abscess) • Aspiration (liquids or solids are sucked into lungs) (for lung abscess) • Having bowel surgery (for abdominal abscess) • For women: having an intrauterine contraceptive device (IUD) in place for many years (for abscess affecting the reproductive organs)
  5. 5. Cervicofacial Actinomycosis • This is the most common and recognized presentation of the disease. • Actinomyces species are commonly present in high concentrations in tonsillar crypts and gingivodental crevices. • Many patients have a history of poor dentition, oral surgery or dental procedures, or trauma to the oral cavity. • Chronic tonsillitis, mastoiditis, and otitis are also important risk factors for actinomycosis.
  6. 6. Infection Cervicofacial region • Periostitis or osteomyelitis can develop if the infection extends to facial and maxillary bones. • The mandible appears to be one of the most common osteomyelitis sites.
  7. 7. Abdominal Actinomycosis
  8. 8. Examination of discharges will help in diagnosis • Examination of drained fluid under a microscope shows "sulphur granules" in the fluid. They are yellowish granules made of clumped organisms
  9. 9. Typical appearance of histopathological examination with special stains Dr.T.V.Rao MD 12
  10. 10. • The smears revealed radiating filamentous colonies of Actinomyces in a background of neutrophilic exudates; • PAS stain also showed Actinomyces colonies.
  11. 11. Mycetoma • Mycetoma is a chronic subcutaneous infection caused by actinomycetes or fungi. • This infection results in a granulomatous inflammatory response in the deep dermis and subcutaneous tissue, which can extend to the underlying bone.
  12. 12. Mycetoma • Mycetoma is characterized by the formation of grains containing aggregates of the causative organisms that may be discharged onto the skin surface through multiple sinuses. • Mycetoma was first described in the mid 1800s and initially named Madura foot, after the region of Madura in India where the disease was first identified.
  13. 13.
  14. 14. • Slow spreading skin infection • Local swelling • Small hard painless nodules • Ulceration • Pus discharge • Sinuses • Scarred skin & discolouration • Itching • Pain & Burning sensation if superinfected Clinical features
  15. 15. • Direct microscopy: • Blood- Leukocytosis & neutrophilia • Culture of exudates • Skin biopsy • Serology. DIAGNOSIS.
  16. 16. Excised mycetoma showing a draining sinus (cut open in this preparation) containing black grains.
  17. 17. H&E stainskin biopsy H&E stained tissue section showing blacked grained eumycotic mycetoma caused by Madurella mycetomatis.
  18. 18. • Granulomatous Inflammation With Abscess Formation. • A Central Zone Exists Where Polymorphonuclear Cells Are Abundant And Granules Or Grains Are Found. • This Central Zone Is Surrounded By Lymphocytes, Plasma Cells, Histiocytes, And Fibroblasts. Histopathological Findings

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