Zürich Universität- Vetsuisse Fakultät
Klinik für Kleintiermedizin
Dermatologie Abteilung

Human & canine atopic dermatiti...
Human versus canine AD
• Many similarities and some (minor)
differences
CAD: Definition (Halliwell for ICADA, 2008)
• A genetic predisposed, inflammatory and
pruritic dermatitis, that often deve...
CAD: Localization
32%

58%

32%

42%

62%

75%
80%

66%
CAD: A familial disease
Genetic make-up
Food

Food

UV

Stress
Microbes
Stress

Impaired epidermal
barrier

+

Impaired imm.syst.
Th2 responders
H...
Diagnosis of CAD
•
•
•

Exclusion of resembling diseases
Criteria
Allergy tests:
–
–
–

IgE serology
Intradermal testing
E...
Major allergens
• House dust mites and storage mites. 90%
–
–
–
–

Dermatophagoides Farinae
DP, AC, Tyrophagus
Numerous cr...
Role of food
• Food hypersensitivity
–
–

Atopic dermatitis
Urticaria, Angioedema, GI

• Elimination diet and provocation
...
CAD treatment
•
•
•

Glucocorticoids and Calcineurin inhibitors
Systemically rather than topically
Allergen-specific immun...
Allergy march in atopic dogs?
• Food allergy in younger dogs?
• Pollen allergy before mites allergy?
Conclusion
• Human atopic dermatitis is a good model
for canine atopic dermatitis 
Any
question?
Human & canine atopic dermatitis: Similarities and differences
Human & canine atopic dermatitis: Similarities and differences
Human & canine atopic dermatitis: Similarities and differences
Human & canine atopic dermatitis: Similarities and differences
Human & canine atopic dermatitis: Similarities and differences
Human & canine atopic dermatitis: Similarities and differences
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Human & canine atopic dermatitis: Similarities and differences

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GRF 2nd One Health Summit 2013: Presentation by Claude Favrot, ECVD Vetsuisse Faculty, Zurich

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Human & canine atopic dermatitis: Similarities and differences

  1. 1. Zürich Universität- Vetsuisse Fakultät Klinik für Kleintiermedizin Dermatologie Abteilung Human & canine atopic dermatitis: Similarities and differences Prof. Dr Claude Favrot, MsSc, Dip.ECVD Vetsuisse Faculty, Zurich
  2. 2. Human versus canine AD • Many similarities and some (minor) differences
  3. 3. CAD: Definition (Halliwell for ICADA, 2008) • A genetic predisposed, inflammatory and pruritic dermatitis, that often develops in association with environmental allergenspecific IgE
  4. 4. CAD: Localization 32% 58% 32% 42% 62% 75% 80% 66%
  5. 5. CAD: A familial disease
  6. 6. Genetic make-up Food Food UV Stress Microbes Stress Impaired epidermal barrier + Impaired imm.syst. Th2 responders High IgE responders Climate Irritant contact d. Allergic contact d. + Allergenes: Environmental, food, microbes, autoallergens Microbes Contactants Atopic dermatitis, Atopic-like dermatitis Favrot, 2011
  7. 7. Diagnosis of CAD • • • Exclusion of resembling diseases Criteria Allergy tests: – – – IgE serology Intradermal testing Elimination diet
  8. 8. Major allergens • House dust mites and storage mites. 90% – – – – Dermatophagoides Farinae DP, AC, Tyrophagus Numerous cross reactions Derf15 >Derf1, Derf2 • Pollens. 30% – Cedar, Ragweed, Birch, Dandelion... • Molds: 50% • Epithelia: 5%
  9. 9. Role of food • Food hypersensitivity – – Atopic dermatitis Urticaria, Angioedema, GI • Elimination diet and provocation – IgE driven?
  10. 10. CAD treatment • • • Glucocorticoids and Calcineurin inhibitors Systemically rather than topically Allergen-specific immunotherapy – 70% success rate • New trends: – – Jak inhibitors: Oclacitinib C kit inhibitors: Masitinib
  11. 11. Allergy march in atopic dogs? • Food allergy in younger dogs? • Pollen allergy before mites allergy?
  12. 12. Conclusion • Human atopic dermatitis is a good model for canine atopic dermatitis 
  13. 13. Any question?

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