World’s leader  in allergy and  clinical immunology
The Leader … 42 National Societies, more than 7000 academicians,  researchers and clinicians
National societies GARD WHO EFA EAACI Patient Organizations committee EU Research  Networks Predicta Medall EuroPrevall Al...
Matrix Organization of Sections & IGs: The Matrix Allied health Epidemiology Junior Members Ocular allergy Allergy Diagnos...
Congresses The Quality
 
Allergy Impact factor: 6.2 PAI Impact factor: 2.7 EAACI newsletter EAACI monographs New EAACI E-Journal Clinical and Trans...
 
Food Quality & Safety Quality & Safety of Skin Care Products
EAACI Congress 2012, Geneva
The School
Bern-Interlaken Davos Dubrovnik Prague Rotterdam Davos Chalkidiki Antalya Oxford Bischenberg– Bischoffsheim  Helsinki Lond...
Body surfaces: Skin 0.5%   Mucosas 99.5% Lung: 100 m 2 Gut:  300 m 2 1 Ton food mixed  with water per year 10 14  bacteria...
Immune system is a  highly interactive  networking,  which makes ist  decisions  on the basis of  input  from  all  organs...
Allergens Sensitization Phase IgE eosinophil mucosal  epithelium Th2/Th0 apoptosis Effector Phase x x x x x x x x x x x x ...
 
Las Meninas , 318x276 cm Prado Museum- Madrid 1656 , Diego Velàsquez
Pablo Picasso Las Meninas  161x129 cm Musée Picasso - Barcelone
 
Allergies as a global problem Age 13-14year  Asher MI Lancet 2006,368,733-743 <ul><li>2 0-30%  of world population suffer ...
What we do not know ? <ul><li>R isk factors associated with  development of allergy in  various  populations ( e.g rural  ...
Framework programmes – budget  (in billion Euro)
CK-CARE Global Allergy Forum GAF-Davos Immunobiology of allergic inflammation WG4 C. Akdis, M. Akdis, K. Blaser, B. Bochne...
Research Problems <ul><li>Causes of allergy are unknown </li></ul><ul><li>Reasons for recent increase in prevelance are un...
Allergy /Asthma in Research FP <ul><li>In 1 - 6  FP allergy and  asthma have not been listed  as thematic priorities  </li...
Food allergy  <ul><li>Thirty years ago no one had ever heard of food allergies </li></ul><ul><li>Today 1-2% of adults and ...
<ul><li>Galenos  (129   -201)     the f irst physician:  relationship between  nose and lung </li></ul><ul><li>  </li></ul...
GA²LEN Network of Excellence Collaboration centres Partners 26 partners 60  collaborating cente rs
Allergy in 7th FP ( 2007-2013)  <ul><li>MedAll  –  (2010 -2014) Mechanisms of  development of allergy  </li></ul><ul><li>F...
2010 -2015 WP no. Work package  WP 1 Longitudinal cohort WP 2 Mouse models WP 3 Epithelial models WP 4 Virus-bacteria inte...
Ted’s  friends are laughing at him… He is the only one in the class  without allergy !
Solution Networking & incentives for efficient collaborative  research among clinicians, biologists/immunologists,  epidem...
Solution Increase worldwide awareness and  embrace all parties
Solution Develop evidence based One Health and  (The Science of One Health)
 
Thank you
<ul><li>In 1st to 6 th  FP allergy and asthma were not listed as them atic priorities   </li></ul><ul><li>In 2001 EAACI op...
CK-CARE Action-I Induction of immune tolerance to allergens - Establish an immune tolerance subgroup Use direct approaches...
CK-CARE Action-II A  CK-CARE patient cohort should be established and  a continuous flow of specimens should be provided  ...
Allergic diseases  in  7 FP <ul><li>« Allergy »  was  covered in the Food section of the  7th  programme     </li></ul><ul...
EU Framework Programs <ul><li>1984: First Framework Programme (1984-1987) </li></ul><ul><li>1987: SecondFramework Programm...
<ul><li>Amendment 114 Annex I, Chapter I &quot;Cooperation&quot;, Theme 1 &quot;Health&quot;, Subtitle &quot;Activities&qu...
BUT there are Geographic Differences There is v little allergy in Athens and NO reported allergy to peanut There is a lot ...
But  …improvement in  managing food allergies  needs data which have been lacking   <ul><li>How many people suffer from  s...
<ul><li>European programme to stimulate research </li></ul><ul><ul><li>7 Thematic priorities </li></ul></ul><ul><ul><ul><u...
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European Platform for Chronic and Respiratory Diseases

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GRF One Health Summit 2012, Davos: Presentation by Prof. Cezmi A. Akdis - Director - Swiss Institute of Allergy and Asthma Research SIAF / President - European Academy of Allergy Clinical Immunology EAACI

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European Platform for Chronic and Respiratory Diseases

  1. 1. World’s leader in allergy and clinical immunology
  2. 2. The Leader … 42 National Societies, more than 7000 academicians, researchers and clinicians
  3. 3. National societies GARD WHO EFA EAACI Patient Organizations committee EU Research Networks Predicta Medall EuroPrevall AllFUN Cohorts The Umbrella EAACI Dieticians EAACI GPs Allergy Nurses and other allied health JMA EAACI Mentorship Programme
  4. 4. Matrix Organization of Sections & IGs: The Matrix Allied health Epidemiology Junior Members Ocular allergy Allergy Diagnosis Functional genomics&proteomics Infection and allergy
  5. 5. Congresses The Quality
  6. 6.
  7. 8. Allergy Impact factor: 6.2 PAI Impact factor: 2.7 EAACI newsletter EAACI monographs New EAACI E-Journal Clinical and Translational Allergy www.ctajournal.com
  8. 10. Food Quality & Safety Quality & Safety of Skin Care Products
  9. 11. EAACI Congress 2012, Geneva
  10. 12. The School
  11. 13. Bern-Interlaken Davos Dubrovnik Prague Rotterdam Davos Chalkidiki Antalya Oxford Bischenberg– Bischoffsheim Helsinki London Davos Venice Madeira Davos Norwich Fischbachau, Germany Mykonos, Greece Ancona, Italy EAACI Schools 2003-12 Berlin Sardinia Kusadasi Verona Saariselkä Krakow Athens Grainau Pickl Hannover Grainau äre Edinburgh Porto Heli, Greecei
  12. 14. Body surfaces: Skin 0.5% Mucosas 99.5% Lung: 100 m 2 Gut: 300 m 2 1 Ton food mixed with water per year 10 14 bacteria 1 kg 2000 species =12*0.6*60*24*365*80 3‘027‘456‘000 liters 10 billion particles (3 perLiter) 1 kg 1 1/2 Tennis court
  13. 15. Immune system is a highly interactive networking, which makes ist decisions on the basis of input from all organs and tissues, infections, normal flora bacteria, and many or even any environmental agents
  14. 16. Allergens Sensitization Phase IgE eosinophil mucosal epithelium Th2/Th0 apoptosis Effector Phase x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x x
  15. 18. Las Meninas , 318x276 cm Prado Museum- Madrid 1656 , Diego Velàsquez
  16. 19. Pablo Picasso Las Meninas 161x129 cm Musée Picasso - Barcelone
  17. 21. Allergies as a global problem Age 13-14year Asher MI Lancet 2006,368,733-743 <ul><li>2 0-30% of world population suffer from allergies </li></ul><ul><li>High morbidity and may be life-threatening </li></ul><ul><li>Affect social life of patients </li></ul><ul><li>High economic impact of the society </li></ul>
  18. 22. What we do not know ? <ul><li>R isk factors associated with development of allergy in various populations ( e.g rural vs. urban or children vs elderly) </li></ul><ul><li>Basic mechanism of development , persistence and progression ( e.g. role of infections) </li></ul><ul><li>Effective measures to prevent development and progression of allergies </li></ul><ul><li>Cost effective treatment modalities </li></ul>
  19. 23. Framework programmes – budget (in billion Euro)
  20. 24. CK-CARE Global Allergy Forum GAF-Davos Immunobiology of allergic inflammation WG4 C. Akdis, M. Akdis, K. Blaser, B. Bochner, E-M. de Villiers, A. Fire, S.Galli, G. Marone, M. Mempel, H. zur Hausen,
  21. 25. Research Problems <ul><li>Causes of allergy are unknown </li></ul><ul><li>Reasons for recent increase in prevelance are unkown </li></ul><ul><li>Mechanisms of spontaneous resolution are unknown </li></ul><ul><li>Inadequate understanding of natural mechanisms that limit acute/chronic pathology </li></ul><ul><li>5. Marginal understanding of interactions among microbes, immune system and allergic disorders </li></ul><ul><li>6. Need for better subclassification of allergic disorders based on pathobiology </li></ul><ul><li>7. Need for agents to probe specific pathways in pathogenesis (seeking new therapeutic approaches) </li></ul><ul><li>8. Lack of approaches to prevent allergy </li></ul><ul><li>9. Need for better approaches to predict treatment responses and to monitor treatment effectiveness and disease activity </li></ul><ul><li>10. Need for better preclinical models (to address problems 1-9) </li></ul>
  22. 26. Allergy /Asthma in Research FP <ul><li>In 1 - 6 FP allergy and asthma have not been listed as thematic priorities </li></ul><ul><li>The only relevant themes : </li></ul><ul><ul><li>Food quality and safety </li></ul></ul><ul><ul><li>Environment </li></ul></ul><ul><ul><li>Life sciences, genomic and technology </li></ul></ul>
  23. 27. Food allergy <ul><li>Thirty years ago no one had ever heard of food allergies </li></ul><ul><li>Today 1-2% of adults and 4-8% of children suffer from food allergy </li></ul><ul><ul><li>10 millions people in Europe </li></ul></ul><ul><li>Reactions may be severe and life threatening </li></ul><ul><li>Management : </li></ul><ul><ul><li>avoidance is difficult </li></ul></ul><ul><ul><li>n o effective prevention is available </li></ul></ul>
  24. 28. <ul><li>Galenos (129 -201) the f irst physician: relationship between nose and lung </li></ul><ul><li> </li></ul><ul><li>EU funding: 14,4 million € (5 years) </li></ul>Global Allergy and Asthma European Network ( Network of Excellence)
  25. 29. GA²LEN Network of Excellence Collaboration centres Partners 26 partners 60 collaborating cente rs
  26. 30. Allergy in 7th FP ( 2007-2013) <ul><li>MedAll – (2010 -2014) Mechanisms of development of allergy </li></ul><ul><li>FAST - 7 FP (2007-2012) New vaccines against food allergy: fish and fruits </li></ul><ul><li>Predicta – 7FP ( 2010-2015) Viral infections and allergy </li></ul><ul><li>Allergy 31 projects </li></ul><ul><li>Asthma 35 projects </li></ul>13
  27. 31. 2010 -2015 WP no. Work package WP 1 Longitudinal cohort WP 2 Mouse models WP 3 Epithelial models WP 4 Virus-bacteria interactions WP 5 Immune regulation WP 6 Resolution of inflammation WP 7 Diagnostics WP 8 Interventions WP 9 Management
  28. 32. Ted’s friends are laughing at him… He is the only one in the class without allergy !
  29. 33. Solution Networking & incentives for efficient collaborative research among clinicians, biologists/immunologists, epidemiologists and bioinformaticians, in collaborating groups elsewhere, to solve all of the unresolved questions Research, Research, Research Meet to discuss results
  30. 34. Solution Increase worldwide awareness and embrace all parties
  31. 35. Solution Develop evidence based One Health and (The Science of One Health)
  32. 37. Thank you
  33. 38. <ul><li>In 1st to 6 th FP allergy and asthma were not listed as them atic priorities </li></ul><ul><li>In 2001 EAACI open the office in Brussels </li></ul><ul><li>Task : lobbying for allergy themes in European FP </li></ul>
  34. 39. CK-CARE Action-I Induction of immune tolerance to allergens - Establish an immune tolerance subgroup Use direct approaches (tonsil, lymph node) Start clinical trials Detailed analyses of patients (e.g., deep sequencing of mRNAs and DNAs) Meet again to evaluate the data
  35. 40. CK-CARE Action-II A CK-CARE patient cohort should be established and a continuous flow of specimens should be provided (e.g., to CK-CARE network and collaborating outside laboratories) for broad „discovery“ research For endotypes/subtypes of asthma Identify endotypes (define biomarkers) Identify causative molecular mechanisms Clone and express biologicals Start clinical trials
  36. 41. Allergic diseases in 7 FP <ul><li>« Allergy » was covered in the Food section of the 7th programme </li></ul><ul><li>EAACI and GA²LEN were raising awareness on the need to have « allergic diseases » in the Health theme </li></ul><ul><ul><li>Meeting with the Rapporteur – prof. Jerzy Buzek February 2006 </li></ul></ul><ul><ul><li>Presentation to the members of EP in Brussels -March 2006 </li></ul></ul>
  37. 42. EU Framework Programs <ul><li>1984: First Framework Programme (1984-1987) </li></ul><ul><li>1987: SecondFramework Programme (1987-1991) </li></ul><ul><li>1990: Third Framework Programme (1990-1994) </li></ul><ul><li>1994: Fourth Framework Programme (1994-1998) </li></ul><ul><li>1998: FifthFramework Programme (1998-2002) </li></ul><ul><li>2000: European Research Area </li></ul><ul><li>2002: SixthFramework Programme (2002-2006) </li></ul><ul><li>2005: Proposal for the Seventh Framework Programme </li></ul><ul><li>2007: Seventh Framework Programme (2007-2013 ) </li></ul>
  38. 43. <ul><li>Amendment 114 Annex I, Chapter I &quot;Cooperation&quot;, Theme 1 &quot;Health&quot;, Subtitle &quot;Activities&quot;, bullet 2, indents 3 and 4 </li></ul><ul><li>In the latest version of the FP7 framework text, “allergy” is proposed to be included under the Health theme , “Translating research for human health”, “Translational research in major diseases” as : </li></ul><ul><li>“ respiratory diseases, including those induced by allergies“. </li></ul>Respiratory allergies in 7FP
  39. 44. BUT there are Geographic Differences There is v little allergy in Athens and NO reported allergy to peanut There is a lot of food allergy in Amsterdam to all the foods
  40. 45. But …improvement in managing food allergies needs data which have been lacking <ul><li>How many people suffer from specific food allerg ies in Europe? </li></ul><ul><li>What are the risk factors/causes? </li></ul><ul><li>What is the impact on quality of life? </li></ul><ul><li>How much does food allergy cost to society? </li></ul>
  41. 46. <ul><li>European programme to stimulate research </li></ul><ul><ul><li>7 Thematic priorities </li></ul></ul><ul><ul><ul><ul><li>Food Quality and Safety </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Topic Allergy and asthma </li></ul></ul></ul></ul><ul><li>Instruments T42 Allergy and asthma </li></ul><ul><ul><ul><ul><li>Integrated Projects </li></ul></ul></ul></ul><ul><ul><ul><ul><li>Networks of Excellence </li></ul></ul></ul></ul>2002-2006

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