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Potentially hazardous substances are used with increasing frequency in modern life. Consequently, the potential for human exposure to these substances is a major concern globally. This paper examines a method developed in the 1983 to 1985 at the USA Environmental Protection Agency. The author of this paper was the principal investigator of that method. The computer based method developed estimates urban population distribution in specified units of geography during twelve 2-hour periods of the day. The population distributions are further disaggregated by sex and age categories. Since the development of this method significant advances in the resolution, comparability and frequency of available remotely sensed data have been made. These data lend themselves very well to a modernization of this method, the usefulness of this method in urban areas globally and improved quality of the results of the model. Recommended improvements to this method are discussed, practicality of use is assessed and a prototypical model of the method is offered using southwestern Colorado USA as a study area.