Dr David Keegan - AGM 2011 - DCCR Overview

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Dr David Keegan gives an overview of the Dublin Centre for Clinical Trails at the Fighting Blindness AGM - Oct 1, 2011

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Dr David Keegan - AGM 2011 - DCCR Overview

  1. 1. DCCR Dublin Centre for Clinical Research Wellcome Trust – HRB Dublin Centre for Clinical Research 01 October 2011 By David Keegan Chair of Ophthalmology Division of DCCR
  2. 2. <ul><li>In 2006 three Dublin Medical Schools (TCD, RCSI and UCD) responded to a Wellcome Trust call to fund clinical research infrastructure. </li></ul><ul><li>Dublin application scored second and this resulted in €23M in funding from the Wellcome Trust and Health Research Board: </li></ul><ul><ul><li>~€10m the development of a Clinical Research Centre (CRC) at St. James’s Hospital </li></ul></ul><ul><ul><li>Five years operational funding (~€13m) for DCCR Network and St. James’s Hospital Clinical Research Facility </li></ul></ul>DCCR Dublin Centre for Clinical Research About the Dublin Centre for Clinical Research (DCCR)
  3. 3. <ul><ul><li>Transformation of clinical research in Dublin through development of physical, human resource and administrative infrastructure for safe, ethical and excellent patient-focused research </li></ul></ul>DCCR Dublin Centre for Clinical Research DCCR’s Vision
  4. 4. Components of Vision <ul><ul><li>Excellence in research </li></ul></ul><ul><ul><li>Up-skilling and enlargement of research nursing and clinician scientist pool </li></ul></ul><ul><ul><li>Provision of a clinical research IT Infrastructure </li></ul></ul><ul><ul><li>Streamlining inter-institutional research protocols </li></ul></ul><ul><ul><li>Integration of research programmes with clinical research infrastructure </li></ul></ul><ul><ul><li>Completion of Dublin’s clinical research facility infrastructure with the construction of a CRC at St. James’s Hospital </li></ul></ul>DCCR Dublin Centre for Clinical Research
  5. 5. DCCR Dublin Centre for Clinical Research
  6. 6. <ul><ul><li>Research Nursing Development: </li></ul></ul><ul><ul><li>Recruitment of Network Research Nurses – 8 Network Nurses Now in Place </li></ul></ul><ul><ul><li>Common GCP Training – 4 courses in 2009 and 5 courses in 2010 </li></ul></ul><ul><ul><li>Certificate Course in Research Nursing – 12 candidates 2009 - 10 candidates 2010 </li></ul></ul><ul><ul><li>Revival of Irish Research Nurses Network </li></ul></ul><ul><ul><li>Further post graduate education for nurses and other clinical research </li></ul></ul>DCCR Dublin Centre for Clinical Research DCCR’s Research Network Infrastructure
  7. 7. Information Technology Infrastructure <ul><ul><li>Professional IT Manager (John McCourt) started in April 2009 </li></ul></ul><ul><ul><li>IT function has a cross institutional mandate </li></ul></ul><ul><ul><li>IT Priority: IT that supports multisite clinical research activities: </li></ul></ul><ul><ul><ul><li>Study Management </li></ul></ul></ul><ul><ul><ul><li>eCRF </li></ul></ul></ul><ul><ul><ul><li>Sample tracking </li></ul></ul></ul><ul><ul><ul><li>Research Ethics </li></ul></ul></ul>DCCR Dublin Centre for Clinical Research
  8. 8. Wellcome Trust – HRB Clinical Research Facility at St. James’s Hospital DCCR Dublin Centre for Clinical Research
  9. 9. Wellcome Trust – HRB Clinical Research Centre at St. James’s Hospital DCCR Dublin Centre for Clinical Research Neurophysiology Suite (EEG) CAMI 3T MRI Exercise Physiology Lab Six Bed Unit Four Isolation Rooms Gene Therapy Pharmacy
  10. 10. <ul><ul><ul><li>Ophthalmology – David Keegan </li></ul></ul></ul><ul><ul><ul><ul><li>Registry of Patients with Severe Retinal Dystrophy </li></ul></ul></ul></ul><ul><ul><ul><li>Diabetes Group – John Nolan </li></ul></ul></ul><ul><ul><ul><ul><li>GUIDANCE Study (EASD) – completed with 946+ patients recruited by 17 Consultants </li></ul></ul></ul></ul><ul><ul><ul><li>Respiratory Medicine Group – Michael Keane </li></ul></ul></ul><ul><ul><ul><ul><ul><li>IPF/Sarcoidosis – Bio – repository - 215+ patients recruited to date </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Device for Asthma Patients – Going through ethics for six hospital sites </li></ul></ul></ul></ul></ul><ul><ul><ul><li>Gastroenterology Group – Ross McManus </li></ul></ul></ul><ul><ul><ul><ul><ul><li>Coeliac Disease DNA collection – ongoing – 200 + samples collected in 9 months </li></ul></ul></ul></ul></ul><ul><ul><ul><ul><ul><li>Barrett’s Oesophagus – Invited to participate in WT Case Control Consortium </li></ul></ul></ul></ul></ul><ul><ul><ul><li>Inflammatory Skin Disease – Alan Irvine </li></ul></ul></ul><ul><ul><ul><ul><ul><li>WT and Children’s Research Foundation funding for international collection of 4000 samples from Children with Eczema to start in 2010 </li></ul></ul></ul></ul></ul><ul><ul><ul><li>Neuropsychiatry – Michael Gill </li></ul></ul></ul><ul><ul><ul><ul><li>Extension of Wellcome Trust Case Control Consortium Study of patients with psychosis </li></ul></ul></ul></ul><ul><ul><ul><li>Prostate Cancer Research Consortium – Mark Lawler </li></ul></ul></ul><ul><ul><ul><ul><li>Continued investigation of potential biomarkers </li></ul></ul></ul></ul><ul><ul><ul><li>Infectious Diseases (HIV/TB) – Paddy Mallon/Colm Bergin </li></ul></ul></ul><ul><ul><ul><ul><li>Latent TB Incidence, HIV and TB and TB immunity and Vitamin D (studies in planning) </li></ul></ul></ul></ul><ul><ul><ul><li>Neurodegeneration – Hardiman </li></ul></ul></ul><ul><ul><ul><ul><li>Registry for Young Onset Neurodegeneration </li></ul></ul></ul></ul>DCCR’s Clinical Research Networks DCCR Dublin Centre for Clinical Research
  11. 11. Ophthalmology and the DCCR <ul><li>An important part of DCCR strategy </li></ul><ul><li>To integrate existing registers while designing new items </li></ul><ul><li>To develop the regulatory strategy </li></ul><ul><li>Successful gene therapy trials in eye disease </li></ul><ul><li>Develop more novel treatments </li></ul>DCCR Dublin Centre for Clinical Research
  12. 12. Progress to Date <ul><li>Commenced process for ethical approval for specific registers to identify patients with inherited retinal disease </li></ul><ul><li>Modular fashion </li></ul><ul><li>Ethical approval and CRF developed </li></ul><ul><li>First three clinics have taken place </li></ul>DCCR Dublin Centre for Clinical Research
  13. 13. The Team <ul><li>Jeremy Townes </li></ul><ul><li>John McCourt </li></ul><ul><li>Marie Burke </li></ul><ul><li>Paul Kenna </li></ul><ul><li>Jane Farrar </li></ul><ul><li>Andrew Greene </li></ul><ul><li>Avril Daly </li></ul><ul><li>Anna Moran </li></ul>DCCR Dublin Centre for Clinical Research
  14. 14. Next Phase <ul><li>Build numbers </li></ul><ul><li>Collate the various registers that exist </li></ul><ul><li>Expand and include more comprehensive information </li></ul>DCCR Dublin Centre for Clinical Research
  15. 15. Regulation <ul><li>Experience of other groups </li></ul><ul><li>Major stumbling black </li></ul><ul><li>There for a reason </li></ul><ul><li>Safety </li></ul><ul><li>Pathway to therapy </li></ul>DCCR Dublin Centre for Clinical Research
  16. 16. Therapy <ul><li>Gene Therapy </li></ul><ul><li>Neuro-protectants </li></ul><ul><li>Retinal implants </li></ul><ul><li>Stem cells </li></ul>DCCR Dublin Centre for Clinical Research
  17. 17. Any Questions DCCR Dublin Centre for Clinical Research

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