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Knowledge has been gathered from ten years of interdisciplinary addiction research as
well as from two years of experience of the first German Alcohol and Baclofen Forum.
This brochure aims at giving an overview of the present state of treatment methods of
addiction, anxiety, and depression.
This „Blackbox“ and the matching „Whitebox“ contain more than forty authentic user
reports covering their experiences over a period of 6 to 24 months. They provide a clear
picture:
„The End of my Addiction“ remains no longer solely the individual experience of a
French cardiologist (O. Ameisen, 2004). Moreover it is the reality as experienced by
numerous patients and the doctors who treat them – out of necessity – relying on „offlabel-use“.
1.7 million Germans are addicted to alcohol or consume alcohol in a risky fashion.
According to recent estimates this causes damage to the national economy roughly
22.5 billion Euro per year (DHS, Deutsche Hauptstelle für Suchtfragen). Every year
alcolhol is the cause of 73.000 deaths (BZgA, Bundeszentrale für gesundheitliche
Aufklärung).
For more than ten years a paradigm shift in science and research has been observed.
Brandnew therapeutic approaches with significantly improved chances of recovery
have become possible. Numerous studies with Baclofen that have been carried out
since 1994 confirm it to be an effective anti-craving-medication.
Up to now German media have ignored this development. That is why we choose the
internet platform to inform about progress that has been made in treating addiction,
anxiety, and depression. Our main targets are doctors, therapists, and above all
afflicted persons and their relatives.
The end of addiction is no longer utopia – it has come true for an increasing
number of patients who have successfully been treated with Baclofen.
„Abstinence is by no means any longer the aim of initial treatment of alcohol problems“
(K. Mann and F. Kiefer, 2010).
© 2011 www.paradigmenwandel.org in cooperation with www.alkohol-und-baclofen-forum.de

2
10 statements on the mode of effect of Baclofen, as
in off-label-use for addiction, anxiety, and depression,
as carried out by treating doctors and their patients
covering a timeframe of six to 24 months.

Friedrich Kreuzeder
Addiction Counseling / Coaching,
Founder / Administrator
www.alkohol-und-baclofen-forum-de

Dr. Cornelia Weigel
Internal Medicine/Addiction Medicine
Center for Drug Addiction
Prevention Giessen

Ulrich Hammerla
General Practitioner,
Addiction Medicine,
Psychotherapy

Dr. Holger Bergmann
General Practitioner

Prof. Dr. Christian Haasen
Psychiatry, Psychotherapy
Addiction Medicine and Research
altomed-mvz Hamburg

Dr. Bernd Hündersen
Sociologist, Executive Director
Center for Drug Addiction
Prevention Giessen

„They are surprised and realize that the
indispensability of alcohol that has
accompanied them for their whole life
has suddenly disappeared.“
Annie Rapp, Paris
(Physician and Psychotherapist)

3
1 Baclofen is a safe anti-craving-medication
2 Baclofen causes no addiction (shift of addiction)
3 Baclofen is ideally suitable for outpatient therapy
4 Baclofen is suitable for long term therapy
5 Baclofen has few side effects
6 Baclofen can be combined (interaction)
7 Baclofen is an effective anti-craving-medication
8 Baclofen can positively influence depression and anxiety
9 Baclofen enables undisturbed interaction in psychotherapy
10 Baclofen can contribute to „inner quietness“ (calmness)

4
In

1 Baclofen is a safe anti-craving-medication

After more than 40 years of using Baclofen in neurology for spasm
relief as part of therapy for Multiple Sclerosis not a single case of death
has been reported.

Well documented complications describe mostly neurological cases
of intrathecal application occurring due to failure of pump systems.
All cases described could be treated well and had no long term
consequence. When treating alcohol addiction the medication is
taken orally.

In one single case Baclofen was used with suicidal intention with
a hundred-fold dosage of 2.5mg. After usual emergency intervention
that attempt also remained without any negative consequences.

5
2 Baclofen causes no addiction (shift of addiction)

It is known from user reports that single intakes of Baclofen are
occasionally forgotten. There is a tendency from a higher dosage at the
beginning to clearly lowering the dosage in the long run.
Development of tolerance can be ruled out with great likelihood.

One case has been reported in which a dosage of up to 450 mg was
applied for several months. The following reduction to 125 mg did not result
in the loss of effectiveness.

Some users gradually reduce Baclofen after a couple of months
for various reasons. When craving reappears another series of therapy
can be started without any problem, but then in most cases the earlier
dosage is not exceeded.

6
2 Baclofen besitzt kein eigenes Abhängigkeitspotenzial
als
3 Baclofen is ideally suitable for outpatient therapy

Outpatient therapy with Baclofen is the rule, clinical treatment is
only necessary in exceptional cases.

Missuse can be widely ruled out because Baclofen does not lead up
to a significant tolerance. Likewise intoxicating or stimulating effects have
not occurred.

A potentially substitutive effect for alcohol was mentioned in a singular
claim from Sweden without, however, delivering any factual evidence.
Due to the very low price of the medication the interest of in street
trafficking is strictly limited.

7
4 Baclofen is suitable for long term therapy

Experience in long term therapy over periods of more than ten years
are available from neurological practice. So far neither mental nor
physical impairments (side effects) have been mentioned.

Having used Baclofen at a dosage of 125 mg/d in the treatment of his
alcoholism for seven years Olivier Ameisen seems to have the longest
experience up to now. He does not see any reason to discontinue (2011).

High effectiveness has been shown in a first study with 132 patients at
Université Descartes, Paris, in 2011. More than 80% of patients who were
treated with Baclofen for more than one year proved highly successful.
The first study was the ideal basis for the currently starting phase-IV-study
(2011/2012) which has been funded by state funds as the first European
study.

8
5 Baclofen has few side effects

In the studies that have been published so far, mainly fatigue and
occasionally vertigo are reported. These side effects disappeared after
the first weeks and were described by most patients as tolerable.
Other effects such as loss of libido, dry mouth, sleep disorders, euphoria,
depression, edema, and muscle pain were rare and disappeared after
a period of adaptation. Therefore it is important to individually adapt
and slowly increase the dosage until the desired result is reached.

Termination of therapy due to unbearable side effects has mainly been
ascribed to a lack of individual motivation. In many cases such patients
had been urged by members of their families or by employers to seek
therapy. This problem is well known from conservative withdrawal therapies.

9
6 Baclofen can be combined (interaction)

In more than 80% of all cases of alcoholism comorbidities with other
psychiatric diseases are to be expected. The most common previous
illnesses are anxiety disorders, PTSD, and depression. In addition there is
growing evidence of borderline and ADHS.
Interactions with sedating antidepressants may occur resulting in a
boost of effects. Occasionally combinations of Baclofen with psychopharmacological drugs are unavoidable. They should always be handled
by cooperating with an experienced physician or therapist.
The combination with benzodiazepines is always risky. With existing renal
insufficiency tight control is recommended. This also applies to cases of less
than normal lung function.

10
7 Baclofen is an effective anti-craving-medication

For the time being Naltrexone and Acamprosate are the only anti craving
medications admitted for the treatment of alcoholism. Studies have shown
that both medications work only slightly better than or just as effective as
placebos.
Naltrexone as well as Acamprosate are inappropriate for long-term use
because a damaging effect on the organs is to be expected. Therefore the
time of usage should be limited to three months. Nalmefene as a successor
to Naltrexone will be admitted in 2012; an up to 50% reduction of the drinking
amount has been defined as the aim of this treatment.
As it seems commonly accepted that even after years of abstinence craving
can lead to a relapse, Baclofen remains the only effective medication currently
available. Because of its good tolerance treatment is only rarely interrupted or
terminated. This may be attributed to its additional mood stabilizing effect.

11
8 Baclofen can positively influence depression and anxiety

In more than 66% of user reports on Baclofen a fast reduction of anxiety
and depression is described. Frequently fast improvement or complete
disappearance of symptoms is reported. If the basic pre-morbidity is a
generalized anxiety disorder, symptoms often improve rapidly.
When speaking about alcoholism anxiety and depression are mistakenly
regarded solely as withdrawal symptoms without classifying them as
pre-morbidity. In many cases no anxiety disease has been diagnosed at all.
I told all my doctors: 'I use alcohol as a tranquilliser. If you rid me of anxiety,
I'll stop drinking.' My doctors all told me: 'You're anxious because you drink.
Stop drinking and your anxiety will subside.'
Olivier Ameisen, „The End of My Addiction“

12
9 Baclofen enables undisturbed interaction in psychotherapy

Craving makes interaction with the therapist impossible.
Brain activities shown in functional magnetresonance tomography (f MRT)
clearly indicate the effects of craving. The patient is under severe tension and
cannot be reached in such a state.
Sedating, calming medications do suppress craving but – due their effect –
they do not permit interaction.
Under therapy some topics evoke strong emotions and/or stress in patients
triggering craving without the therapist being explicitly and necessarily aware
of this. The patient is forced to spend his total energy to fight off the pressure
of addiction. Under such circumstances any therapy is bound to fail.

13
10 Baclofen can contribute to „inner quietness“ (calmness)

Baclofen enhances the effect of gamma-a-Aminobutryc acid (GABA) in the
brain. This transmitter is regarded as the most important „calming, inhibiting“
substance of the central nervous system. After several months of using
Baclofen there is a clear tendency towards a positive state of mind,
perceived as „inner quietness“. In therapeutic settings relaxation techniques
(i.e. autogenic training, Jacobson’s progressive muscle relaxation) are used
of to achieve a quite similar state of mind as with Baclofen.
Such techniques have been resorted to for just a few months or unfortunately
have been administered only occasionally. In situations that appear to be
difficult and stressful to the individual patient the chance of relapsing becomes
much higher.
In such situations Baclofen users temporarily and shortly increase the dosage
and reach the state of „inner quietness“ without much effort-before craving can
trigger off a relapse.

14
Background:
The enhanced understanding of biological processes in the neurotransmitter system attributes
the symptom of alcoholism to a breakdown of inner balance. This results in a completely novel
understanding of diseases based on substance addiction. In this context brand-new possibilities
for the treatment of anxiety and depression open up (Cryan, Kaupmann, 2005).
In particular Baclofen thus far known as muscle relaxant seems to have the potential to restore
this balance as an agonist of the GABA-B-receptor. The application of Baclofen has been
carried out in neurology for more than 40 years without any significant side-effects. The curative
success of the French cardiologist O. Ameisen in alcoholism and co-morbidity with anxiety and
dysphoria by self-medication with Baclofen is striking. A change of paradigm in the treatment of
alcohol addiction has started. The main objective of treatment is not just abstinence
(Uchtenhagen, 2009), but also the suppression of craving.
Objective:
Treating alcoholism with Baclofen should become a safe option in medical routine. This opens
up new facilities in treatment and in the prevention of relapses. Baclofen is part of a successful
therapy achieving a craving free state of mind with socially and health compatible consumption
of alcohol or content abstinence. The results of several web-based surveys within the “Alkoholund-Baclofen-Forum” (Rippel, Kreuzeder 2010) founded by affected people, as well as numerous practical observations (Müller, Volkmar et al. 2010), seem to justify “off-label-prescription”,
especially when considering the cost/benefit ratio and the low success rates of the established
forms of therapy.
Results and conclusions:
Considering the interindividual difference in dose requirement, Baclofen often allows a quick
stop of drinking and - respectively - a reduction of consumption of alcohol up to “complete indifference”. Influencing common comorbidities such as anxiety and depression positively, leads
to an efficient, individualized psychotherapy and improves the ability of self-organization.
Weigel C, Kreuzeder FJ (2011): Suchtmedmedizin 13,3, 125-126, Suchttherapie 12, S48-S49,
Suchttherapie 12, 4, 190

Literature:
Cryan JF, Kaupmann K (2005): Don’t worry `B`happy!: a role for GABAB receptors in anxiety and depression. Trends in Pharmacological Sciences
26, 36-43
Ameisen O (2005): Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a
self-case report of a physician. Alcohol and Alcoholism 40, 2, 147-150
Uchtenhagen A (2009): Abstinenz als gesellschaftlicher und therapeutischer Leitgedanke. Suchttherapie 10, 75– 80
Rippel H, Kreuzeder F (2010) Efficacy of Baclofen in the treatment of alcoholism: http://www.paradigmenwandel.org/Publikationen_files/efficacy
%20of%20baclofen.pdf
Müller C, Vollmer K, Hein J, Heinz A.(2010): Baclofen zur Behandlung der Alkoholabhängigkeit. Sucht 56 (3-4), 167-174

15
Experience reports are to be found in Whitebox
http://pdfcast.org/pdf/whitebox

16 typical reports by patients with an
experience range between 6 band 26 months
in off-label-use and predominantly under
supervision of their treating doctors.

Further experience reports in the forum.
!
!
!
!
!
!
http://alkohol-und-baclofen-forum.de

16

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Blackbox(englisch)

  • 1. 1
  • 2. Knowledge has been gathered from ten years of interdisciplinary addiction research as well as from two years of experience of the first German Alcohol and Baclofen Forum. This brochure aims at giving an overview of the present state of treatment methods of addiction, anxiety, and depression. This „Blackbox“ and the matching „Whitebox“ contain more than forty authentic user reports covering their experiences over a period of 6 to 24 months. They provide a clear picture: „The End of my Addiction“ remains no longer solely the individual experience of a French cardiologist (O. Ameisen, 2004). Moreover it is the reality as experienced by numerous patients and the doctors who treat them – out of necessity – relying on „offlabel-use“. 1.7 million Germans are addicted to alcohol or consume alcohol in a risky fashion. According to recent estimates this causes damage to the national economy roughly 22.5 billion Euro per year (DHS, Deutsche Hauptstelle für Suchtfragen). Every year alcolhol is the cause of 73.000 deaths (BZgA, Bundeszentrale für gesundheitliche Aufklärung). For more than ten years a paradigm shift in science and research has been observed. Brandnew therapeutic approaches with significantly improved chances of recovery have become possible. Numerous studies with Baclofen that have been carried out since 1994 confirm it to be an effective anti-craving-medication. Up to now German media have ignored this development. That is why we choose the internet platform to inform about progress that has been made in treating addiction, anxiety, and depression. Our main targets are doctors, therapists, and above all afflicted persons and their relatives. The end of addiction is no longer utopia – it has come true for an increasing number of patients who have successfully been treated with Baclofen. „Abstinence is by no means any longer the aim of initial treatment of alcohol problems“ (K. Mann and F. Kiefer, 2010). © 2011 www.paradigmenwandel.org in cooperation with www.alkohol-und-baclofen-forum.de 2
  • 3. 10 statements on the mode of effect of Baclofen, as in off-label-use for addiction, anxiety, and depression, as carried out by treating doctors and their patients covering a timeframe of six to 24 months. Friedrich Kreuzeder Addiction Counseling / Coaching, Founder / Administrator www.alkohol-und-baclofen-forum-de Dr. Cornelia Weigel Internal Medicine/Addiction Medicine Center for Drug Addiction Prevention Giessen Ulrich Hammerla General Practitioner, Addiction Medicine, Psychotherapy Dr. Holger Bergmann General Practitioner Prof. Dr. Christian Haasen Psychiatry, Psychotherapy Addiction Medicine and Research altomed-mvz Hamburg Dr. Bernd Hündersen Sociologist, Executive Director Center for Drug Addiction Prevention Giessen „They are surprised and realize that the indispensability of alcohol that has accompanied them for their whole life has suddenly disappeared.“ Annie Rapp, Paris (Physician and Psychotherapist) 3
  • 4. 1 Baclofen is a safe anti-craving-medication 2 Baclofen causes no addiction (shift of addiction) 3 Baclofen is ideally suitable for outpatient therapy 4 Baclofen is suitable for long term therapy 5 Baclofen has few side effects 6 Baclofen can be combined (interaction) 7 Baclofen is an effective anti-craving-medication 8 Baclofen can positively influence depression and anxiety 9 Baclofen enables undisturbed interaction in psychotherapy 10 Baclofen can contribute to „inner quietness“ (calmness) 4
  • 5. In 1 Baclofen is a safe anti-craving-medication After more than 40 years of using Baclofen in neurology for spasm relief as part of therapy for Multiple Sclerosis not a single case of death has been reported. Well documented complications describe mostly neurological cases of intrathecal application occurring due to failure of pump systems. All cases described could be treated well and had no long term consequence. When treating alcohol addiction the medication is taken orally. In one single case Baclofen was used with suicidal intention with a hundred-fold dosage of 2.5mg. After usual emergency intervention that attempt also remained without any negative consequences. 5
  • 6. 2 Baclofen causes no addiction (shift of addiction) It is known from user reports that single intakes of Baclofen are occasionally forgotten. There is a tendency from a higher dosage at the beginning to clearly lowering the dosage in the long run. Development of tolerance can be ruled out with great likelihood. One case has been reported in which a dosage of up to 450 mg was applied for several months. The following reduction to 125 mg did not result in the loss of effectiveness. Some users gradually reduce Baclofen after a couple of months for various reasons. When craving reappears another series of therapy can be started without any problem, but then in most cases the earlier dosage is not exceeded. 6
  • 7. 2 Baclofen besitzt kein eigenes Abhängigkeitspotenzial als 3 Baclofen is ideally suitable for outpatient therapy Outpatient therapy with Baclofen is the rule, clinical treatment is only necessary in exceptional cases. Missuse can be widely ruled out because Baclofen does not lead up to a significant tolerance. Likewise intoxicating or stimulating effects have not occurred. A potentially substitutive effect for alcohol was mentioned in a singular claim from Sweden without, however, delivering any factual evidence. Due to the very low price of the medication the interest of in street trafficking is strictly limited. 7
  • 8. 4 Baclofen is suitable for long term therapy Experience in long term therapy over periods of more than ten years are available from neurological practice. So far neither mental nor physical impairments (side effects) have been mentioned. Having used Baclofen at a dosage of 125 mg/d in the treatment of his alcoholism for seven years Olivier Ameisen seems to have the longest experience up to now. He does not see any reason to discontinue (2011). High effectiveness has been shown in a first study with 132 patients at Université Descartes, Paris, in 2011. More than 80% of patients who were treated with Baclofen for more than one year proved highly successful. The first study was the ideal basis for the currently starting phase-IV-study (2011/2012) which has been funded by state funds as the first European study. 8
  • 9. 5 Baclofen has few side effects In the studies that have been published so far, mainly fatigue and occasionally vertigo are reported. These side effects disappeared after the first weeks and were described by most patients as tolerable. Other effects such as loss of libido, dry mouth, sleep disorders, euphoria, depression, edema, and muscle pain were rare and disappeared after a period of adaptation. Therefore it is important to individually adapt and slowly increase the dosage until the desired result is reached. Termination of therapy due to unbearable side effects has mainly been ascribed to a lack of individual motivation. In many cases such patients had been urged by members of their families or by employers to seek therapy. This problem is well known from conservative withdrawal therapies. 9
  • 10. 6 Baclofen can be combined (interaction) In more than 80% of all cases of alcoholism comorbidities with other psychiatric diseases are to be expected. The most common previous illnesses are anxiety disorders, PTSD, and depression. In addition there is growing evidence of borderline and ADHS. Interactions with sedating antidepressants may occur resulting in a boost of effects. Occasionally combinations of Baclofen with psychopharmacological drugs are unavoidable. They should always be handled by cooperating with an experienced physician or therapist. The combination with benzodiazepines is always risky. With existing renal insufficiency tight control is recommended. This also applies to cases of less than normal lung function. 10
  • 11. 7 Baclofen is an effective anti-craving-medication For the time being Naltrexone and Acamprosate are the only anti craving medications admitted for the treatment of alcoholism. Studies have shown that both medications work only slightly better than or just as effective as placebos. Naltrexone as well as Acamprosate are inappropriate for long-term use because a damaging effect on the organs is to be expected. Therefore the time of usage should be limited to three months. Nalmefene as a successor to Naltrexone will be admitted in 2012; an up to 50% reduction of the drinking amount has been defined as the aim of this treatment. As it seems commonly accepted that even after years of abstinence craving can lead to a relapse, Baclofen remains the only effective medication currently available. Because of its good tolerance treatment is only rarely interrupted or terminated. This may be attributed to its additional mood stabilizing effect. 11
  • 12. 8 Baclofen can positively influence depression and anxiety In more than 66% of user reports on Baclofen a fast reduction of anxiety and depression is described. Frequently fast improvement or complete disappearance of symptoms is reported. If the basic pre-morbidity is a generalized anxiety disorder, symptoms often improve rapidly. When speaking about alcoholism anxiety and depression are mistakenly regarded solely as withdrawal symptoms without classifying them as pre-morbidity. In many cases no anxiety disease has been diagnosed at all. I told all my doctors: 'I use alcohol as a tranquilliser. If you rid me of anxiety, I'll stop drinking.' My doctors all told me: 'You're anxious because you drink. Stop drinking and your anxiety will subside.' Olivier Ameisen, „The End of My Addiction“ 12
  • 13. 9 Baclofen enables undisturbed interaction in psychotherapy Craving makes interaction with the therapist impossible. Brain activities shown in functional magnetresonance tomography (f MRT) clearly indicate the effects of craving. The patient is under severe tension and cannot be reached in such a state. Sedating, calming medications do suppress craving but – due their effect – they do not permit interaction. Under therapy some topics evoke strong emotions and/or stress in patients triggering craving without the therapist being explicitly and necessarily aware of this. The patient is forced to spend his total energy to fight off the pressure of addiction. Under such circumstances any therapy is bound to fail. 13
  • 14. 10 Baclofen can contribute to „inner quietness“ (calmness) Baclofen enhances the effect of gamma-a-Aminobutryc acid (GABA) in the brain. This transmitter is regarded as the most important „calming, inhibiting“ substance of the central nervous system. After several months of using Baclofen there is a clear tendency towards a positive state of mind, perceived as „inner quietness“. In therapeutic settings relaxation techniques (i.e. autogenic training, Jacobson’s progressive muscle relaxation) are used of to achieve a quite similar state of mind as with Baclofen. Such techniques have been resorted to for just a few months or unfortunately have been administered only occasionally. In situations that appear to be difficult and stressful to the individual patient the chance of relapsing becomes much higher. In such situations Baclofen users temporarily and shortly increase the dosage and reach the state of „inner quietness“ without much effort-before craving can trigger off a relapse. 14
  • 15. Background: The enhanced understanding of biological processes in the neurotransmitter system attributes the symptom of alcoholism to a breakdown of inner balance. This results in a completely novel understanding of diseases based on substance addiction. In this context brand-new possibilities for the treatment of anxiety and depression open up (Cryan, Kaupmann, 2005). In particular Baclofen thus far known as muscle relaxant seems to have the potential to restore this balance as an agonist of the GABA-B-receptor. The application of Baclofen has been carried out in neurology for more than 40 years without any significant side-effects. The curative success of the French cardiologist O. Ameisen in alcoholism and co-morbidity with anxiety and dysphoria by self-medication with Baclofen is striking. A change of paradigm in the treatment of alcohol addiction has started. The main objective of treatment is not just abstinence (Uchtenhagen, 2009), but also the suppression of craving. Objective: Treating alcoholism with Baclofen should become a safe option in medical routine. This opens up new facilities in treatment and in the prevention of relapses. Baclofen is part of a successful therapy achieving a craving free state of mind with socially and health compatible consumption of alcohol or content abstinence. The results of several web-based surveys within the “Alkoholund-Baclofen-Forum” (Rippel, Kreuzeder 2010) founded by affected people, as well as numerous practical observations (Müller, Volkmar et al. 2010), seem to justify “off-label-prescription”, especially when considering the cost/benefit ratio and the low success rates of the established forms of therapy. Results and conclusions: Considering the interindividual difference in dose requirement, Baclofen often allows a quick stop of drinking and - respectively - a reduction of consumption of alcohol up to “complete indifference”. Influencing common comorbidities such as anxiety and depression positively, leads to an efficient, individualized psychotherapy and improves the ability of self-organization. Weigel C, Kreuzeder FJ (2011): Suchtmedmedizin 13,3, 125-126, Suchttherapie 12, S48-S49, Suchttherapie 12, 4, 190 Literature: Cryan JF, Kaupmann K (2005): Don’t worry `B`happy!: a role for GABAB receptors in anxiety and depression. Trends in Pharmacological Sciences 26, 36-43 Ameisen O (2005): Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen: a self-case report of a physician. Alcohol and Alcoholism 40, 2, 147-150 Uchtenhagen A (2009): Abstinenz als gesellschaftlicher und therapeutischer Leitgedanke. Suchttherapie 10, 75– 80 Rippel H, Kreuzeder F (2010) Efficacy of Baclofen in the treatment of alcoholism: http://www.paradigmenwandel.org/Publikationen_files/efficacy %20of%20baclofen.pdf Müller C, Vollmer K, Hein J, Heinz A.(2010): Baclofen zur Behandlung der Alkoholabhängigkeit. Sucht 56 (3-4), 167-174 15
  • 16. Experience reports are to be found in Whitebox http://pdfcast.org/pdf/whitebox 16 typical reports by patients with an experience range between 6 band 26 months in off-label-use and predominantly under supervision of their treating doctors. Further experience reports in the forum. ! ! ! ! ! ! http://alkohol-und-baclofen-forum.de 16