Definition & types of jaundice

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Definition & types of jaundice

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Definition & types of jaundice

  1. 1. Definition & Types of Jaundice<br />By: Fahad Al Hulaibi<br />
  2. 2. :Definition<br />Jaundice is a yellow discoloration of the sclerae and skin, as a result of raised serum bilirubin, and is usually detectable clinically when the bilirubin is greater than 3mg/dL.<br />Clinical Medicine, Kumar & Clark, 4th edition<br />
  3. 3. Types:<br />1- Haemolytic jaundice<br />2- Congenital hyperbilirubinemia.<br />3- Cholestatic jaundice.<br />Clinical Medicine, Kumar & Clark, 4th edition<br />
  4. 4. Type 1:Haemolytic jaundice<br />The increased breakdown of red cells<br /> leads to an increase in production of bilirubin.<br />causes of haemolytic jaundice are those of haemolyticAnaemia.<br />The resulting jaundice is usually mild.<br />level of unconjugatedbilirubin is raised,<br />but the serum transferasesand alkaline phposphateare normal.<br />Clinical Medicine, Kumar & Clark, 4th edition<br />
  5. 5. Type 2:Congenital hyperbilirubinemia<br />Most common is Gilbert’s syndrome .<br />Mutation in the gene coding for :<br />UDP-glucuronosyltransferase.<br />asymptomatic and is usually detected as an incidental finding of a slightly raised Bilirubin (1–6mg/dL).<br />There is a family history of jaundice in 5–15% of patients.<br />The reticulocyte count is normal, excluding haemolysis, and no treatment is necessary.<br />Clinical Medicine, Kumar & Clark, 4th edition<br />
  6. 6. Type 3:Cholestaticjaundice<br />Can be devided into:<br />Intra-hepatic Cholestatic:<br />Cased by hepatocellular swelling in parenchymal liver disease or abnormalities at a cellular level of bile excertion.<br />aminotransferasesand alkaline phposphate ??<br />Extra-hepatic Cholestasis:<br />Resulting from obstruction of bile flow at any point distal to the bile canaliculi.<br />Clinical Medicine, Kumar & Clark, 4th edition<br />
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  8. 8. Thanks<br />

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