Expoquimia 2011: Forum Biotech - Francesc Rabanal

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Expoquimia 2011: Forum Biotech - Francesc Rabanal

  1. 1. CHEMISTRY & BIOTECHNOLOGY Francesc Rabanal University of Barcelona http://www.qo.ub.es/personals/frabanal.htm
  2. 2. CHEMISTRY: PETROLEUM CHEMICALS PLASTICS, FUELS BIOTECHNOLOGY: AGRICULTURE FEEDSTOCKS
  3. 3. BIOTECHNOLOGY and CHEMISTRY: A CLASSIC EXAMPLE SEMISYTHETIC PENICILLINS FERMENTATION to obtain 6-aminopenicillanic acid (6-APA) or 7-aminocephaloesporanic acid (7-ACA) Chemical ans enzymatic processes: SEMISYTHETIC PENICILLINS and CEFALOSPORINS: Amoxicillin, ampicillin, cephalexin etc ca 30 billion euros 65% of antibiotic market
  4. 4. CHEMICAL INDUSTRY € 1300 billion turnover; 10 million employees Moving to GREEN Chemistry, WHITE Biotechnology: € 116 billion (2008) to 450 billion (2020) Sustainable methods Renewable stocks Reduce pollutants (greenhouse effect gases…) Save energy and water
  5. 5. BIOMATERIALS Biodegradable polymers: poly(hydroxyalkanoates) (starch-based materials sugars, cellulose etc) synergy chemist/biotechnologist for product improvement (bioplastics) KEY AREAS and EXAMPLES
  6. 6. KEY AREAS and EXAMPLES CHEMICAL COMMODITIES 1,3-propanediol, 3-hydroxypropionic acid, lactic acid (from corn sugar) succinic acid (paints, textiles, coatings…) from carbohydrates and biomass polyethylene (from sugar cane)
  7. 7. NEW PROCESSES in development: polypropylene (from sugar cane) biobased terephtalic acid (furandicarboxylic acid, from sugar) 1,4-butandiol (from renewable carbohydrate feedstock), use as a solvent, fine chemical, polymers (polybutylene terephtalate) Adipic acid (from glucose polyurethanes, nylon 6,6) Acrolein and acrylic acid from glycerin KEY AREAS and EXAMPLES
  8. 8. Example: Adipic acid from glucose O O OH HO OH + O H2 O2 HNO3 Adipic acid from benzene (crude oil) O OH H OH OH OH OH Glucose O OH HO OH OH OH OH O Glucaric acid O O OH HOH2 O2 Adipic acid Adipic acid Adipic acid from glucose (renewable process)
  9. 9. KEY AREAS and EXAMPLES Biofuels: Bioethanol: from sugar cane to starch/lignocellulosic sources enzymatic process to obtain glucose from cellulose, recycle agricultural waste (glucose is to Biotech like crude oil is to Chemical industry) Biodiesel: from inedible crops
  10. 10. Summary and Conclusions Clear synergies and expertise-sharing between Chemistry and Biotechnology to produce chemical commodities and biomaterials. Cost-effective and sustainable processes are being developed and tendency will continue to expand Big Chemical Companies are complementary to Biotechs
  11. 11. References 1) H. Tullo, Chemical Engineering News, 88, 15-7 (2010) 2) The Economist, 2010, http://www.economist.com/node/16492601 3)M. N. Gupta, S. Raghava, Chemistry Central Journal, 1, 17, (2007)

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