Quadruple helix dna and epigenetics in rheumatism genes
Estefanía Reza Loaiza Medical Student 3rd Semester
University of Cambridge (2013, January 20).Quadruple helix DNA discovered in humancells. Researches at Cambridge recently reported that there are quadruple structure DNA in human cancer cells.
Scientists believe it may be possible to halt therunaway cell proliferation at the root of cancer bymarking the quadruplexes with synthetic moleculesthat trap the genetic sequences and stop the DNAreplication during cell division.
By using antibodyproteins, theresearchers wereable to identify thequadruple-structuresDNA in humancells, especiallyduring the S-Phaseof cell division.
The researchers also reported that a gene with ahigher level of quadruple DNA is more vulnerable toexternal interference.
The finding of a whole different DNAstructure within the human cellsneeds to be moreinvestigated, since it could led to anew approach towards cancer andoncogenes studies
Johns Hopkins Medicine (2013, January 20).Epigenetics explains rheumatism? Genes andtheir regulatory tags conspire to promoterheumatoid arthritis. Scientists at Johns Hopkins and The Karolinska Institutet have spotted tagged DNA sequences important in the development of rheumatoid arthritis.
Some tags depend on specific DNA sequences, whileothers depend on cellular processes and environmentalchanges. The investigators catalogued DNA sequencesand tagging patterns in the white blood cells of 300people in order to identify the two types of taggingevents.
As they were able to trackthe tag in DNA sequencesimplicated in rheumatoidarthritis, the treatment forthis disease can have amajor improve, sinceclinicians can directly attackthe implicated genes andtheir tag.
The researchers also reported that theamount of variation found in some taggingevents give individuals a greater chance ofadapting to environmental changes, andthis is why some genetic sequences haveto be preserved.
The important part of this research is thatthe results can explain the relationshipbetween epigenetics and the developmentof not only rheumatoid arthritis, but otherdiseases with a genetic risk.
The study of epigenetics and DNAstructure is very importantnowadays because it brings newanswers about genetic andautoimmune diseases.
One of the most importantthings about this kind ofinvestigations is that they notonly clear things about thedevelopment and riskfactors, but they shed a newlight about the treatment.It means, existing treatmentscan be changed andimproved, and also, newtreatments can be developed.
Tagging DNA sequences and marking genes can provide abetter overview about the development and process ofmany diseases.
Talking specifically about the quadruplex DNA, wecan be sure about the importance of this researchwhen it comes to cancer treatment, since theinvestigators proved that DNA replication in cancercells can be blocked.
• University of Cambridge (2013, January 20). Quadruple helix DNA discovered in human cells.• Johns Hopkins Medicine (2013, January 20). Epigenetics explains rheumatism? Genes and their regulatory tags conspire to promote rheumatoid arthritis.