A presentation at NAVS Summerfest 6/29/12                 Stephan Esser MD                www.esserhealth.com
Prostate CA and Plant-Based          Nutrition                    Stephan Esser MD                   www.esserhealth.com
Goals• Review definitions and tenets• Overview of the Statistics• Visit the classroom: anatomy,  physiology• Brief review ...
NOT Goals• Personal recommendations for  screening or treatment• Updates on surgical techniques• Intro to alternative trea...
By the end you will……• Know more about cancer development• Know what the prostate is and what it does• Know signs and symp...
Definition– Etymology: Middle English, from Latin, literally,  crab; akin to Greek karkinos crab– a northern zodiacal cons...
“Cancer is a term used for diseases in     which abnormal cells divide   without control and are able to        invade oth...
Levels of the Organism•   Atomic: Oxygen•   Molecular: DNA•   Organelle: Nucleus of the cell•   Cellular: Cell•   Tissue: ...
Cell Cycle             G1: Growth and             function             S: DNA Replication             G2: Preparation     ...
Cancer Growth
Cell Cycle             G1: Growth and             function             S: DNA Replication             G2: Preparation     ...
Cancer Operatives• 1: Failure to slow/block abnormal growth• 2: Acceleration of growth (ie: to an abnormal  level)
Cancer Subtypes• Carcinoma: skin or tissues that line/cover  internal organs• Sarcoma: begin in bone, cartilage, fat, musc...
Valuable Terminology• Staging: evaluates the extent of a  persons cancer• Grading: how abnormal a tumor looks  under a mic...
What we know!• Cancer is an abnormal state of the cell• It is often caused by dysfunction in the cell  cycle• Overgrowth/i...
Basic Epidemiology
Mortality Statistics 2006-2007
Cancer deaths per year
Cancer RiskTotal 1:6
In Review• Cancer is the 2nd leading cause of death• Prostate Cancer is the 2nd leading cause of  cancer death in men• Can...
Mini- Med School
Anatomyhttp://healthinessbox.files.wordpress.com/2012/04/prostrate-health.jpghttp://www.cancer.gov/PublishedContent/Images...
Anatomy Cont’d http://healthinessbox.files.wordpress.com/2012/04/prostrate-health.jpg http://www.cancer.gov/PublishedConte...
Dysfunction• Prostatitis• Benign Prostatic Hypertrophy• Prostate Cancer
Development• 11th-12th week of gestation• Exponential growth during puberty  – 2ndary to androgens (testosterone and deriv...
Physiology• Function:  – Exocrine gland which produces a milky white    slightly alkaline fluid  – Expelled into the ureth...
Prostate Cancer Symptoms• Early: none• Late:   So does BPH  – Weak stream  – Increased frequency/hesitancy/urgency  – Bloo...
To screen or not to screen• Early: none• Basic: Digital Rectal Exam• Laboratory: 1980’s PSA, by 2001 75% of men  over 50 y...
Is screening always good?  Autopsy series suggest that 30%• 1986 men older than 50 years of    of – 2005   – 1 million men...
What Causes Prostate Cancer?
What causes any Cancer?• Loss of normal cell division
Risk Factors      Non-Modifiable               Modifiable•   Age >50/40            •    # of Sexual partners•   Family Hi...
What we know• Men who consume the highest amounts of  – Vegetables, fruits, beans, lentils etc  risk     • 7th day Advent...
Cancer Growth
Mechanisms for Development• High blood androgen concentrations• Increased blood levels of IGF-1 derived from  dairy• Incre...
Benefits of Plant-Based Foods• ’d blood androgen concentrations• ’d blood levels of IGF-1• ’d exposure to carcinogens r...
A few Studies
Prostate CA and Diet• Dean Ornish et al Journal of Urology 2005  – Men with low-mod level of biopsy proven PCA  – 1 year o...
Diet Changes Gene Expression• Ornish et al PNAS 2008  – 31 men with biopsy proven PrCA  – 3 months of Ornish program  – Re...
Now What
By the end you will……• Know more about cancer development• Know what the prostate is and what it does• Know signs and symp...
What we know• Prostate CA is a problem• Plant-Based nutrition has minimal risk• Plant-Based nutrition appears to reduce ri...
Thank You!
Enjoy more powerpoints and   educational resources at    www.esserhealth.com
Prostate Cancer and Plant Based Nutrition
Prostate Cancer and Plant Based Nutrition
Prostate Cancer and Plant Based Nutrition
Prostate Cancer and Plant Based Nutrition
Prostate Cancer and Plant Based Nutrition
Prostate Cancer and Plant Based Nutrition
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Prostate Cancer and Plant Based Nutrition

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Prostate Cancer and Plant Based Nutrition

  1. 1. A presentation at NAVS Summerfest 6/29/12 Stephan Esser MD www.esserhealth.com
  2. 2. Prostate CA and Plant-Based Nutrition Stephan Esser MD www.esserhealth.com
  3. 3. Goals• Review definitions and tenets• Overview of the Statistics• Visit the classroom: anatomy, physiology• Brief review of Prostate cancer• Engage Plant-based Nutrition• Set Goals
  4. 4. NOT Goals• Personal recommendations for screening or treatment• Updates on surgical techniques• Intro to alternative treatments
  5. 5. By the end you will……• Know more about cancer development• Know what the prostate is and what it does• Know signs and symptoms of cancer• Be familiar with the evidence for plant-based nutrition as it relates to PrCa• Be equipped to make educated decisions regarding your health
  6. 6. Definition– Etymology: Middle English, from Latin, literally, crab; akin to Greek karkinos crab– a northern zodiacal constellation between Gemini and Leo b (1) : the fourth sign of the zodiac in astrology– A malignant tumor of potentially unlimited growth that expands locally by invasion and systematically by metastasis– Something evil or malignant that spreads destructively
  7. 7. “Cancer is a term used for diseases in which abnormal cells divide without control and are able to invade other tissues.”
  8. 8. Levels of the Organism• Atomic: Oxygen• Molecular: DNA• Organelle: Nucleus of the cell• Cellular: Cell• Tissue: Cells function together• Organ: multiple Tissues work together• Organ System: respiratory, circulatory etc.• Organism: Human Being
  9. 9. Cell Cycle G1: Growth and function S: DNA Replication G2: Preparation M: Mitosis
  10. 10. Cancer Growth
  11. 11. Cell Cycle G1: Growth and function S: DNA Replication G2: Preparation M: Mitosis
  12. 12. Cancer Operatives• 1: Failure to slow/block abnormal growth• 2: Acceleration of growth (ie: to an abnormal level)
  13. 13. Cancer Subtypes• Carcinoma: skin or tissues that line/cover internal organs• Sarcoma: begin in bone, cartilage, fat, muscle blood vessels or other connective tissues• Leukemia: blood forming tissue. Eg: bone marrow• Lymphoma/Myeloma: cells of the immune system• Central Nervous System: in the brain and spinal cord
  14. 14. Valuable Terminology• Staging: evaluates the extent of a persons cancer• Grading: how abnormal a tumor looks under a microscope
  15. 15. What we know!• Cancer is an abnormal state of the cell• It is often caused by dysfunction in the cell cycle• Overgrowth/inappropriate growth at the cellular level = dysfunction at the tissue/organ = dysfunction at the organism level
  16. 16. Basic Epidemiology
  17. 17. Mortality Statistics 2006-2007
  18. 18. Cancer deaths per year
  19. 19. Cancer RiskTotal 1:6
  20. 20. In Review• Cancer is the 2nd leading cause of death• Prostate Cancer is the 2nd leading cause of cancer death in men• Cancer risk is quite significant
  21. 21. Mini- Med School
  22. 22. Anatomyhttp://healthinessbox.files.wordpress.com/2012/04/prostrate-health.jpghttp://www.cancer.gov/PublishedContent/Images/cancertopics/treatment/prostate/understanding-prostate-cancer-treatment/prostate-booklet-5.jpghttp://www.jeffersonhospital.org/images/staywell/142104.jpghttp://lafeverchestnuts.webstarts.com/uploads/chestnut.jpg
  23. 23. Anatomy Cont’d http://healthinessbox.files.wordpress.com/2012/04/prostrate-health.jpg http://www.cancer.gov/PublishedContent/Images/cancertopics/treatment/prostate/understanding-prostate-cancer-treatment/prostate-booklet-5.jpg http://www.jeffersonhospital.org/images/staywell/142104.jpg http://lafeverchestnuts.webstarts.com/uploads/chestnut.jpg
  24. 24. Dysfunction• Prostatitis• Benign Prostatic Hypertrophy• Prostate Cancer
  25. 25. Development• 11th-12th week of gestation• Exponential growth during puberty – 2ndary to androgens (testosterone and derivatives)• Quiescent till 4th decade, then grows
  26. 26. Physiology• Function: – Exocrine gland which produces a milky white slightly alkaline fluid – Expelled into the urethra – This comprises about 20-30% of ejaculate volume – K, Zinc, Citric Acid, Fructose, free amino acids etc – Also release Prostate Specific Antigen (PSA) • Thins cervical mucus and allows sperm to swim more freely
  27. 27. Prostate Cancer Symptoms• Early: none• Late: So does BPH – Weak stream – Increased frequency/hesitancy/urgency – Blood in urine or semen – Leg Swelling
  28. 28. To screen or not to screen• Early: none• Basic: Digital Rectal Exam• Laboratory: 1980’s PSA, by 2001 75% of men over 50 y/o were being screened• USPTF: – A shift……
  29. 29. Is screening always good? Autopsy series suggest that 30%• 1986 men older than 50 years of of – 2005 – 1 million men received surgery, radiation therapy or both who age and 70% of those older than test would not have been treated without a P.S.A. 70 years of age have occult – Of these 5,000 died soon after surgery and 10,000 to 70,000 suffered prostate cancer Most men more likely to serious complications. – 1/2 had persistent blood in their semen die of other causes despite – 200,000 to 300,000 suffered impotence, incontinence or both. their diagnosis of PrCA – Dr. Richard J. Ablin, founder of the PSA test has called its widespread use a “public health disaster.”
  30. 30. What Causes Prostate Cancer?
  31. 31. What causes any Cancer?• Loss of normal cell division
  32. 32. Risk Factors Non-Modifiable Modifiable• Age >50/40 •  # of Sexual partners• Family History • Hx of STD’s• Personal History • Vasectomy• Race • Nutrition AA>Hisp>White>Asian – Sat. Fat/Meat/Dairy – Calcium • Exercise: 10-30%
  33. 33. What we know• Men who consume the highest amounts of – Vegetables, fruits, beans, lentils etc  risk • 7th day Adventists/Less-Industrialized nations – Meat, dairy, fiber-poor foods  risk • SAD• Migration studies demonstrate ’d risk – Asian men develop same risk for PrCA as white men after 2-3 generations of migration to the US
  34. 34. Cancer Growth
  35. 35. Mechanisms for Development• High blood androgen concentrations• Increased blood levels of IGF-1 derived from dairy• Increased exposure to carcinogens released in the heating of meats• Low levels of ant-oxidant substances and fiber
  36. 36. Benefits of Plant-Based Foods• ’d blood androgen concentrations• ’d blood levels of IGF-1• ’d exposure to carcinogens released in the heating of meats• ’d levels of ant-oxidant substances• ’d fiber consumption
  37. 37. A few Studies
  38. 38. Prostate CA and Diet• Dean Ornish et al Journal of Urology 2005 – Men with low-mod level of biopsy proven PCA – 1 year on Ornish program or regular – PSA  4% and  6% in controls – Serum inhibited Prostate CA cell growth by 70% in diet group and only by 9% in controls
  39. 39. Diet Changes Gene Expression• Ornish et al PNAS 2008 – 31 men with biopsy proven PrCA – 3 months of Ornish program – Repeat biopsy – 48 up-regulated and 453 down-regulated genes – These genes shown to relate to cancer growth and development
  40. 40. Now What
  41. 41. By the end you will……• Know more about cancer development• Know what the prostate is and what it does• Know signs and symptoms of cancer• Be familiar with the evidence for plant-based nutrition as it relates to PrCa• Be equipped to make educated decisions regarding your health
  42. 42. What we know• Prostate CA is a problem• Plant-Based nutrition has minimal risk• Plant-Based nutrition appears to reduce risk of development and slow progression if present Eat More Plants!
  43. 43. Thank You!
  44. 44. Enjoy more powerpoints and educational resources at www.esserhealth.com

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