Microbiology (major microbial diseases)

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Major Diseases

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Microbiology (major microbial diseases)

  1. 1. MICROBES DISEASE TARGET SOURCE / MODE BACTERIAL PATHOGENStreptococcus pyrogenes Streptococcal Upper RT membranes Droplets Pharyngitis Viridams streptococci Sinusitis Upper RT and saliva Normal flora Streptococcus Pneumococcal Lower RT, lungs, Droplets, mucus pneumoniae oneumonia; otitis media; meninges sinusitis meningitis Bacillus anthracis Pulmonary anthrax Upper & lower RT Spore inhaled from animals / products Corynebacterium Diphtheria Upper RT membranes; Dropleta diptheriae also skinHeamophilus influenzae Pharyngitis Upper RT membranes Droplet Mycobacterium Tuberculosis Lower RT; lungs Droplets; droplet nuclei tuberculosis Nocardia brasiliensis Nocardiosis (a form of Lower RT; lungs Spores inhaled from pneumonia) environment
  2. 2. MICROBES DISEASE TARGET SOURCE / MODE BACTERIAL PATHOGEN (continuation...)Legionella pneumophila Legionnaire disease; Lower RT; lungs Aerosol from aquatic pontiac fever habitats Brucella Brucellosis (undulant RT Aerosol from infected fever) animals Bordetella pertussis Whooping cough Upper & lower RT DropletsKlabsiella pneumoniae Ooportunisitic Lower RT lungs Droplets,normal flora, Psuedomonas pneumonias aerosols, fomites aeruginosa Yersinia pestis Pneumonic plague Lower RT lungs Droplets, animal aerosols Mycoplasma Primary atypical Lower RT, lungs Droplets, mucucs pnuemoniae pnuemonia Chlamydiophila Chlamydial pneumonitis Lower RT, lungs Droplets, mucus pnueomoniae
  3. 3. MICROBES DISEASE TARGET SOURCE / MODE BACTERIAL PATHOGEN (Continuation...)Chlamydiophila psittaci Ornithosis (psittacosis) Lower RT, lungs Arosols, droplets from birds Coxiella burnetii Q fever Lower RT, lungs Ticks, aerosols from animals, dust PARASITIC (Protozoan, helminth)Paragonimus westermani Adult lung fluke Lung Tissue; intestine Larvae ingested in raw or under cooked crustacea
  4. 4. MICROBES DISEASE TARGET SOURCE / MODE FUNGAL PATHOGENSHistoplasma capsulatum Histoplasmosis Lower RT, lungs Spores inhaled in dustBlastomyces dermititidis Blastomycosis Lower RT, lungs Spores inhaled Coccidioides immitis Coccidioidomycosis Lower RT, lungs Spores Inhaled (Valley Fever) Cryptococcus Cryptococcosis Lower RT, lungs Yeast inhaled, Can be neoformans normal flora Sporothrix schenckii Sporothrix pneumonia Lower RT, lungs Spores on vegetationPneumocystis (carinii) Pneumocystis Lower RT, lungs Spores widespread, jiroveci pneumonia (PCP) normal flora Aspergillus fumigatus Aspergillosis Lower RT, lungs Spores, widespread in dust, air
  5. 5. MICROBES DISEASE TARGET SOURCE / MODEStaphyloccus aureus Staph food intoxication Small Intestine Food contaminated by human carriersStreptoccus mutans Dental caries Tooth surface Normal flora, salivaActinomyces israeli Actinomycosis Oral membranes; Normal flora; enter cervicofacial area damaged tissue Escherichia coli Traveler’s diarrhea Small intestine Food, water, rare or raw O157:H7 enteritis beef Salmonella typhi Typhoid fever Small intestine Human carriers; food, drink Shigella spp. Bacillary dysentery Large intestine Human carriers; food, flier
  6. 6. MICROBES DISEASE TARGET SOURCE / MODEYersinia Enterocolitica Yersiniosis Small intestine; A zoonosis; food and (Gastroenteritis) lymphatics drinking water Vibrio cholerae Epidemic cholera Small intestine Natural waters; food contaminated by human carriers Helicobacter pylori Gastritis, gastric Esophagus, stomach, Human, cat intestinal ulcers duodenumCampylobacter pylori Enteritis Jejunum (segment of the Water, milk, meat, food small intestine) infection FUNGAL PATHOGENS Aspergillus flavus Aflatoxin poisoning Liver Toxin ingested in food Candida albicans Esophagitis Esophagus Normal flora
  7. 7. MICROBES DISEASE TARGET SOURCE / MODE PARASITIC (PROTOZOAN, HELMINTH)Entamoeba histolytica Amebic dysentery Caecum, appendis, Food, water- colon, rectum contaminated fecal cyst Gardia lambia Gardiasis Duodenum, jejunum Ingested cysts from animal, human carriers Balantidium coli Balantidiosis Large Intestine Swine, contaminated foodCryptosporidium spp. Cryptosporoidosis Small and large intestine Animals, natural waters, contaminated food Toxoplasma gondii Toxoplasmosis Lymph nodes Cats, rodents, domestic animals PARASITIC (PROTOZOAN, HELMINTH)Enterobius vermicularis Pinworm Rectus, anus Eggs ingested from fingers, food
  8. 8. MICROBES DISEASE TARGET SOURCE / MODE PARASITIC (PROTOZOAN, HELMINTH) Ascaris lumbricoides Ascariasis Worms burrow into Fecally contaminated intestinal mucosa food and water containing eggs Trichuris trichiura Trichiuriasis, whipworm Worms invade small Food containing eggs intestine Trichinella spiralis Trichinosis Larvae penetrate Pork and bear meat intestine containing encysted larvae Necator americanus Hook worms Large and small intestine Larvae deposited by fecesAncylostoma duodenale into soil; burrow into feet Fasciola hapatica Sheep liver fluke Large and small intestine Watercrests Taenia saginata Beef tapeworm Large intestine; pork Raw or rare beef or Taenia solium Pork Tapeworm larva can migrate to porkcontaining larval brain forms

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