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EFFETTO WARBURG
1931
@dottssaEPolicicchio
NORMAL CELL
Glucose
GLUT4
glycolysis
Pyruvate Lactate
Mitochondria
O2
TCA cycle
OXPHOS
ATP
@dottssaEPolicicchio
CANCER CELL
Glucose
GLUT4
glycolysis
Pyruvate Lactate
Mitochondria
O2
ATP
@dottssaEPolicicchio
Cancerous cells preferentially use glycolysis for energy
production rather than Oxydative phosphorilation
Le cellule tumor...
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Warburg Effect 1931

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First metabolic change in cancer cell has been described by Otto Heinrich Warburg (1931).

Published in: Health & Medicine
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Warburg Effect 1931

  1. 1. EFFETTO WARBURG 1931 @dottssaEPolicicchio
  2. 2. NORMAL CELL Glucose GLUT4 glycolysis Pyruvate Lactate Mitochondria O2 TCA cycle OXPHOS ATP @dottssaEPolicicchio
  3. 3. CANCER CELL Glucose GLUT4 glycolysis Pyruvate Lactate Mitochondria O2 ATP @dottssaEPolicicchio
  4. 4. Cancerous cells preferentially use glycolysis for energy production rather than Oxydative phosphorilation Le cellule tumorali utilizzano preferenzialmente la via glicolitica, per la produzione di energia, piuttosto che la fosforilazione ossidativa @dottssaEPolicicchio

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