Trimble 12 12-11

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Trimble 12 12-11

  1. 1. EU-US collaboration in the lifesciences: perspectives from the NIH Edward L. Trimble, MD, MPH Center for Global Health National Cancer Institute, NIH, DHHS, USA
  2. 2. Contact information• Ted Trimble: Center for Global Health, National Cancer Institute, NIH, DHHS, USA• Email: tt6m@nih.gov
  3. 3. EU-US collaboration: Watson & Crick
  4. 4. What facilitates collaboration:• We read the same journals• We attend the same meetings• We have visiting professors• We exchange post-doctoral fellows• We have the internet, email, Skype, etc• We have models of global collaboration – Human Genome Project – International Cancer Genetics Consortium
  5. 5. Human Genome Project• 1990-2003• US funding: Department of Energy, NIH National Human Genome Research Institute• Europe: Wellcome Trust, France, Germany• Asia: China, Japan
  6. 6. International Cancer Genome Consortium• To obtain a comprehensive description of genomic, transcriptomic and epigenomic changes in 50 different tumor types and/or subtypes which are of clinical and societal importance across the globe• Countries involved: Australia, Canada, China, EU, France, Germany , India, Italy, Japan, Mexico, Spain, UK, US• Website: http://www.icgc.org/
  7. 7. What hinders collaboration:• Different funding mechanisms, review schedules, and priorities – FP7, NIH Research Project Grant (RPG) pool, etc• Different regulations regarding clinical research – EU Clinical Trials Directive, DHHS Office of Human Research Protection, etc• Availability of novel agents for joint clinical studies – Lack of mutual recognition of Good Manufacturing Process (GMP), different pharmaceutical partners in EU vs US
  8. 8. Examples of ongoing collaborations• Organization for Economic Co-operation and Development (OECD) Global Science Forum – Working Group to Overcome Barriers to Greater International Collaboration in Academic Clinical Trials, chaired by Germany and Spain• International Rare Disease Research Consortium – EU DG Research, NIH, Canadian Institutes of Health Research
  9. 9. Global Alliance for Chronic Diseases• Six major national research funding agencies – Australian NHMRC, Canadian IHR, Chinese AMS, Indian MRC, UK MRC, US NIH• Focus on cardiovascular disease (heart attack and stroke), type II diabetes mellitus, chronic respiratory conditions, and certain common cancers in low- and middle-income countries and among low-income residents of high-income countries• http://www.gacd.org; secretariat: UCL London
  10. 10. EU-US collaboration: Watson & Crick

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