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New Developments in Electrophysiology (EP)

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James Daubert, MD
Duke University Medical Center

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New Developments in Electrophysiology (EP)

  1. 1. New Developments in Electrophysiology (EP) Duke HF Symposium 2016 October 15, 2016 James P. Daubert, MD Professor of Medicine Director, Electrophysiology Section Duke University Medical Center POTENTIAL CONFLICTS: Consulting, DSMB or Honoraria: ACC, ARCA biopharma, Biotronik, Boston Scientific, Cardiofocus, Medtronic, Northwestern Univ., Orexigen Pharmaceuticals Sorin, St. Jude, VytronUS, Heart Metabolics, Zoll. [All under $25,000 per year] Research grants: Biosense-Webster, Boston Scientific, Gilead, Medtronic, NIH/NHLBI, St. Jude
  2. 2. Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest Kudenchuk PJ et al. N Engl J Med 2016. DOI: 10.1056/NEJMoa1514204
  3. 3. The PREDICTS Study: LVEF Non-recovery post MI Brooks, G. C., et al. (2016). J Am Coll Cardiol 67(10): 1186-1196.
  4. 4. Relative Wall Thickness and VT/VF Risk (MADIT-CRT) Biton, Y., et al. (2016). J Am Coll Cardiol 67(3): 303-312.
  5. 5. Vagus Nerve Stimulation: The INOVATE-HF Trial Gold, M. R., et al. (2016). J Am Coll Cardiol.
  6. 6. Device-Based Neuromodulation in Heart Failure Byku, M. and D. L. Mann (2016). JACC Basic Transl Sci 1(3): 95-106.
  7. 7. Leadless Pacemaker: Nanostim Reddy, V. Y., et al. (2015). N Engl J Med 373(12): 1125-1135
  8. 8. TV ICD and S-ICD Geoffrey F. Lewis & Michael R. Gold Nature Reviews Cardiology 12, 398–405 (2015)
  9. 9. ICD Programming can Save Lives Moss, A. J., et al. (2012). NEJM 367(24): 2275-2283. Tan VH et al, Circ EP 2014;7(1): 164-170 Wilkoff, B. L., et al. (2016). Heart Rhythm 13(2): e50-86.
  10. 10. MADIT-CRT Long Term Follow-up Goldenberg, NEJM 2014: 370:1694-1701
  11. 11. Ruschitzka F et al. N Engl J Med 2013;369:1395-1405. CRT in QRSD < 130, EF < 35% ECHO-CRT Sohaib, S. M., et al. (2015). JACC Heart Fail 3(4): 327-336. Deactivating CRT CRT in Non LBBB: MADIT-CRT by QRSD and Morphology
  12. 12. Quadripolar left ventricular leads van Everdingen, W. M., et al. JACCCEP. 2015;1(4):225-237 Behar, J. M., et al. (2015). J Cardiovasc Electrophysiol 26(5): 540-546.
  13. 13. Dukkipati, S. R., et al. (2015). J Am Coll Cardiol 66(12): 1350-1360 Kuck, K. H., et al. (2016). N Engl J Med 374(23): 2235-2245. AF Ablation Advances Contact Force
  14. 14. Contact Force Meta‐Analysis Mohammed Shurrab et al. J Am Heart Assoc 2015;4:e002476 Recurrence Reduction of: total procedure time; ablation time; total fluoroscopic time No difference in major/minor complications or cardiac tamponade
  15. 15. “RCT of Catheter Ablation Versus Medical Treatment of AF in Heart Failure (The CAMTAF Trial)” Hunter, R. J., et al. (2014) Circulation: Arrhythmia and Electrophysiology 7(1): 31-38.
  16. 16. “RCT of Catheter Ablation Versus Medical Treatment of AF in Heart Failure (The CAMTAF Trial)” Hunter, R. J., et al. (2014) Circulation: A/E 7(1): 31-38. MLWHF and SF36 significantly different too
  17. 17. Meta-analysis of AF ablation in HF Al Halabi S et al, JACC CEP. 2015;1(3):200-209 LVEF MLWHF 6-m HW VO2 No difference in adverse events or HF hospitalizations
  18. 18. STAR AF 2 Trial (Persistent AF) Verma A et al, NEJM 2015; 372: 19
  19. 19. The VISTA Randomized Multicenter Trial Di Biase, L., et al. (2015). J Am Coll Cardiol 66(25): 2872-2882.
  20. 20. Thanks!

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