For the Treatment and Prevention      of Bacterial Vaginosis          The Vaginal Ecosystem
For the Treatment and Prevention             of Bacterial Vaginosis                        The Vaginal FloraThe vaginal fl...
For the Treatment and Prevention            of Bacterial VaginosisIn a healthy vaginal flora, "good" and "bad" bacteria co...
For the Treatment and Prevention                  of Bacterial VaginosisComposition and balance of vaginal flora may chang...
For the Treatment and Prevention           of Bacterial Vaginosis            The “Good” and the “Bad” bacteria “Good” bac...
For the Treatment and Prevention             of Bacterial Vaginosis “ Bad “ bacteria - (mainly Gardnerella Vaginalis) :  ...
For the Treatment and Prevention           of Bacterial Vaginosis When the balance between good and bad bacteria within  ...
For the Treatment and Prevention             of Bacterial VaginosisPrevegyne™ vaginal tablets treat Bacterial Vaginosis an...
For the Treatment and Prevention      of Bacterial Vaginosis Good bacteria (lactobacilli) will recolonize and  protect yo...
For the Treatment and Prevention             of Bacterial VaginosisTo learn more about Prevegyne™ visit the section Your P...
For the Treatment and Prevention        of Bacterial VaginosisOur Medical Information Service is available to provideinfor...
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Vaginal ecosystem-en

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The vaginal flora normally contains "good" bacteria and fewer "undesirable" bacteria. When the vaginal pH is at its normal level (between 3.8 and 4.0), a healthy balance is achieved between all these bacteria that coexist to prevent infections. Bacterial Vaginosis occurs when this healthy balance between the "good" bacteria (Lactobacilli) and the "bad" bacteria (Gardnerella) becomes disrupted due to various external risk factors. When the number of "good", protective bacteria decreases, "bad" bacteria take over, leading to Bacterial Vaginosis infection. Prevegyne™ vaginal tablets treat Bacterial Vaginosis by acidifying the vaginal fluid to lower the pH to its physiological level and stimulate the growth of protective bacteria, and they prevent recurrence of Bacterial Vaginosis by ensuring a healthy and long-lasting balance of the vaginal flora. One of the benefits of Prevegyne™ specific formulation is that it rapidly neutralizes the abnormal odour typically caused by Bacterial Vaginosis.

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Vaginal ecosystem-en

  1. 1. For the Treatment and Prevention of Bacterial Vaginosis The Vaginal Ecosystem
  2. 2. For the Treatment and Prevention of Bacterial Vaginosis The Vaginal FloraThe vaginal flora consists of various species of bacteria(microorganisms) which form a film called biofilm on the surface ofthe vaginal mucosa.This biofilm acts as a protective barrier which prevents harmfulbacteria from adhering to the surface of the vaginal mucosa.The vagina is continuously moistened by discharge which helpsmaintain a healthy vaginal flora. Normal discharge is usually clearand without malodor. 2 2
  3. 3. For the Treatment and Prevention of Bacterial VaginosisIn a healthy vaginal flora, "good" and "bad" bacteria coexist in a stateof natural balance.Normal vaginal pH is between 3.8 and 4.2; it means that the vaginalenvironment is acidic. This acidity maintains bacterial balance andhealthy vaginal ecosystem.A change occurring in the pH leads to imbalance of vaginal flora andrisk for infection. 3 3
  4. 4. For the Treatment and Prevention of Bacterial VaginosisComposition and balance of vaginal flora may change under theinfluence of various physiological or external factors: - Age - Sexual activity - Stress - Intra-uterine devices - Hormonal changes (menstrual - Systemic antibiotics cycle, pregnancy, menopause) - Douching - Health condition - Swimming 4 4
  5. 5. For the Treatment and Prevention of Bacterial Vaginosis The “Good” and the “Bad” bacteria “Good” bacteria (mainly lactobacilli)  Represent over 95% of all bacteria present in the vagina and defend against infections: • by producing lactic acid → it helps maintain a healthy acidic pH in the vagina; • by producing hydrogen peroxide (H2O2) in the genital environment→ it provides antimicrobial action. 5 5
  6. 6. For the Treatment and Prevention of Bacterial Vaginosis “ Bad “ bacteria - (mainly Gardnerella Vaginalis) :  are potentially pathogenic, i.e. they have the ability to cause a disease or infection;  proliferate when the vaginal environment becomes alkaline under the influence of physiological or external factors as described earlier;  become pathogenic when overgrowth occurs in the vaginal ecosystem. 6 6
  7. 7. For the Treatment and Prevention of Bacterial Vaginosis When the balance between good and bad bacteria within the vaginal ecosystem is disrupted, the bad bacteria take over and Bacterial Vaginosis symptoms occur, namely:  strong abnormal fishy odour;  more whitish and fluid vaginal discharge. 7 7
  8. 8. For the Treatment and Prevention of Bacterial VaginosisPrevegyne™ vaginal tablets treat Bacterial Vaginosis and help preventfrequent recurrence. • By gradually releasing the specially formulated vitamin C, they acidify the vaginal fluid and restore the vaginal pH back to its physiological level (between 3.8 and 4.2).  The abnormal odour will disappear within few hours following insertion of the first tablet.  Bad bacteria (Gardnerella), which had taken over and disrupted the balance of your vaginal flora, will stop proliferating as the vaginal regains it normal acidic level. 8 8
  9. 9. For the Treatment and Prevention of Bacterial Vaginosis Good bacteria (lactobacilli) will recolonize and protect your vaginal ecosystem. The balance of your vaginal flora will be restored on a sustainable basis. 9 9
  10. 10. For the Treatment and Prevention of Bacterial VaginosisTo learn more about Prevegyne™ visit the section Your PrevegyneTreatment.You can also visit the FAQ section of this web site; you may find theinformation you are looking for.PrevegyneTM is available at the pharmacy counter. Print this pdf sheetand bring it to your pharmacist; it will help him/her order Prevegyne™ foryou if it is currently out of stock.For more information about Bacterial Vaginosis, please visit the othersections of this web site. 10 10
  11. 11. For the Treatment and Prevention of Bacterial VaginosisOur Medical Information Service is available to provideinformation and counselling about your Prevegyne™treatment.If you have any questions, please feel free to contact us at1 888 666-0611 or by e-mail medicalinfo@duchesnay.com.Please note that our opening hours are Monday to Friday,from 8:30 a.m. to 4:30 p.m. (EST). For any emergency, call ahealthcare professional. 11 11

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