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Peptic ulcer disease

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Peptic ulcer disease

  1. 1. PEPTIC ULCER DISEASE ACID PEPTIC DISEASE
  2. 2. • Gastric ulcer • Duodenal ulcer • Gastritis • GERD • Stress ulcers • Zollinger Ellison Syndrome
  3. 3. Peptic ulcer Definition A mucosal defect equal to or greater than 0.5 cm that extent to or beyond muscularis mucosa. These ulcers are caused by increased acid/ pepsin secretion or diminished mucosal defense.
  4. 4. Types • Chronic • Acute Location • Duodenum • Stomach ? (4%) • Gastric and duodenal ulcer together. 10% • Lower oesophagus • Jejunum after anastomosis to stomach • Meckels diverticulm
  5. 5. Gastric / duoedenal ulcer Prevalance H2 receptor inhibitors Proton pump inhibitors Effective treatment against H Pylori • Overall risk , 10% • More common in males • Duodenal ulcer 4 times more common than gastric ulcer • Slight increase in GU due to wide spread use of NSAIDs
  6. 6. D cells ECL cells Cholecystokinin Secretin
  7. 7. Aetiology 1. Helicobacter pylori • urease– urea- ammonia- hypergastrinaemia- increased acid secretion • H. pylori- reduces the gastric mucosal resistance against acid and pepsin. Enzymes, cytotoxins • Local inflammatory response due to cytotoxins • 90% in DU • 70% in GU
  8. 8. 2. Non steroidal anti inflammatory drugs( NSAIDs) • 30% in GU and smaller percentage in DU • More commonly associated with complications • Inhibit cyclooxygenase (COX,1,2) & reduce mucosal protective prostaglandins
  9. 9. Risk factors for NSAIDs induced ulcers • Age > 60 years • Past history of peptic ulcer • Additional steroids • Multiple NSAIDs, • High dose • Individual NSAIDs. Piroxicam, ibuprufen
  10. 10. 3. Heriditary • Positive family history in DU • Blood group O • Increased level of serum pepsinogen 1
  11. 11. 4. Smoking • More prone to develop gastric ulcer than DU • Ulcer less likely to heal and prone to haemorrhage and perforation 5. Stress Burns, Head injury on ventilators
  12. 12. 6. Gastric emptying –Increased---DU –Decreased----GU. (stasis), DG refkux 7. low socioeconomic group/ developing world 8. Steroids- atrophy of mucosa 9. Spicy foods 10. Gastrinoma
  13. 13. Summary (aetiology) (Acid pepsin versus mucosal barrier) • Increased acid and pepsin secretion. – Gastrin, Histamine, acetylcholine, cholecystokinine • Reduced mucosal barrier – H. Pyelori – NSAIDs – Smoking – Decreased bicarbonate production – Decreased protective prostaglandins
  14. 14. Pathology Duodenal ulcer –First part of duodenum –50% on anterior duodenal wall, 50% on posterior wall –Anterior ulcers tend to perforate while posterior tend to bleed –Usually single but can be more than one –Fibrosis – pyloric stenosis –All benign
  15. 15. Pathology Gastric ulcer –Usually single, 2-4 cm, smooth base perpendicular walls –Located on lesser curve but can occur anywhere –Larger than duodenal ulcer –Fibrosis can lead to Hour glass deformity. –Can penetrate into transverse colon, pancreas. –All stomach ulcers are not benign. (4% malignant)
  16. 16. Malignancy in gastric ulcer • Benign ulcers becoming malignant.? • Malignant to start with • All stomach ulcers are considered malignant until proved benign on biopsy & follow up • Always, always take a biopsy of stomach ulcer • 10 well targeted biopsies
  17. 17. Clinical features • Pain abdomen – Epigastrium, may radiate to back – Relation with meals- hunger pain • Periodicity – Episodic- lasting for several weeks (periodicity) • Vomiting • Alteration in weight
  18. 18. • Bleeding – Chronic – Acute • Other symptoms – Dyspepsia, heartburn, epigastric fullness, loss of appetite • Silent – Anaemia – Haemetemesis – Perforation
  19. 19. D/D pain epigastrium • Duodenal ulcer • Gastric ulcer • Gastritis • Carcinoma • GERD • Pancreatitis • Cholecystitis • Biliary colic • Myocardial infarction • Pleuricy • percarditis
  20. 20. Investigations • Blood CP • Stool for occult blood • Serum amylase • Ultrasound abdomen • ECG • CXR
  21. 21. • Esophagogastrduodenoscopy (EGD) • Urea breath test • • Direct detection of urease activity/ H pylori in biopsy specimen • Biopsy of any stomach ulcer
  22. 22. Treatment • Medical • Surgical Goals – pain relief – Eradicate of H. pylori infection – Healing of ulcer – Prevent recurrence
  23. 23. Medical treatment General measures • Cessation of smoking • Avoidance of spicy foods • Avoid NSAIDs if possible • Antacids. Aluminum hydroxide, Magnesium hydroxide
  24. 24. Ulcer reducing drugs • H2 receptors inhibitors – cimetidin – Famotidine – Ranitidin • Pproton pump inhibitors – Omeprazole .40 mg OD – Lansoprazole. 30 mg 12hourly – Pantoprazole 40 mg OD
  25. 25. Eradication of H. pylori • One of the proton pump inhibitors x 02 weeks. Duration may vary • Combination of two antibiotics x 02 weeks – Amoxycillin – Clithromycin – Metronidazole – Tetracycline • Bismuth added
  26. 26. Mucosal protective • Bismuth • Sucralfate • Misoprostol • Cisapride
  27. 27. • Maintenance of treatment – Usually not required in majority after eradication therapy for H. Pylori – Lowest effective dose of proton pump inhibitors for prolonged period
  28. 28. • Surgical treatment • Indications • Perforation • Haemorrhage • Gastric outlet obstruction • Interactable disease – Delayed healing. Ulcer persists despite 3 months of active treatment – Ulcer recurrence with in one year of initial healing despite maintenance therapy
  29. 29. Surgical treatment for uncomplicated duodenal ulcer Aim • Diversion of acid from the duodenum • Reducing the acid/ pepsin secretion • Both of the above
  30. 30. Options • Truncal vagotomy and drainage • Truncal vagatomy and antrectomy • Highly selective vagotomy. First choice • Lparoscopic • Billroth 1 gastrectomy • Billroth 11 gastrectomy • Gastrojejunostomy
  31. 31. Operation for gastric ulcer Goal • To excise the ulcer • To reduce the acid/ pepsin output • To minimize the bile reflux and gastric stasis • Options • Billroth 1 gastrectomy. (Ulcerated part included) • Billroth II gastrectomy (Ulcerated part included) • T.Vagotomy, Drinage and ulcer excision • Proximal gastrectomy
  32. 32. Complications of ulcer surgery • Recurrent ulcerations • Small stomach syndrome • Bile vomiting • Early and late dumping • Post vagotomy diarrhoea • Malignant transformation • Nutritional cosequences • Gall stones
  33. 33. • Complications of peptic ulcer – Haemorrhage – Perforation – Gastric outlet obstruction

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