Saccharomyces Boulardii Probiotic


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Saccharomyces Boulardii is a popular probiotic, is it as good as they say? Does it deserve to be popular?

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Saccharomyces Boulardii Probiotic

  1. 1. SACCHAROMYCES BOULARDII PROBIOTIC By Probiotics Expert: Dr. Raga
  2. 2. What is Saccharomyces boulardii?  Saccharomyces boulardii is a type of yeast (fungus).  In the past, it was thought to be a unique yeast specie but currently it is believed to belong in the strain of Saccharomyces cerevisiae (baker's yeast).  Nowadays, it is described to be one of the internationally most acclaimed probiotic which is used for certain digestive system problems such as IBS, IBD, diarrhea, as well as Candida overgrowth.
  3. 3. Discovery of Saccharomyces boulardii  Originally, Saccharomyces boulardii was derived from lychee and mangosteen fruit by Henri Boulard, a French scientist.  Boulard discovered this strain of yeast during his trip in Indochina. During his stay there, he found out that the yeasts used in the fermentation of wine in France were not effective in Indochina. To make a solution to this problem, he tried to find a certain strain of yeast which could withstand heat.  Also, during Boulard’s Indochina trip, he was faced with disease conditions among the locals, one of which was diarrhea. He discovered that most locals drank tea (from lychee & mangosteen) to stop it.  So, as a result, Boulard was able to extract active strain of yeast that he later on named as S. Boulardii.
  4. 4. Saccharomyces boulardii probiotic Mechanisms 1. Anti-toxin effects  S. Boulardii has been associated with treatment of cholera and enteric pathogen-caused conditions.  Has been found to neutralize the toxins and inhibit the proinflammatory response caused by the pathogens 2. Anti-inflammatory effects  S. Boulardii also prevents the cell signalling mechanism caused by pathogenic agents that commonly occurs in the case of Irritable Bowel Disease (IBD) 3. Trophic effects on enterocytes  Decreases the secretion of interleukin during E. Coli infection. This enables the intestinal mucosa to be protected from its inflammatory effects.
  5. 5. Saccharomyces boulardii probiotic Mechanisms 4. Anti-microbial effect  S. Boulardii does this anti-microbial mechanism by brushing off microbes such as E. Coli and S. Typhimurium (commonly linked to occurrence of acute infectious diarrhea). This happens through the brush border of S. Boulardii. It binds these pathogens there and eliminates these from the body through defecation. 5. Increased immune response  This promotes the binding of immunoglobulin A (IgA) in the small intestines. 6. Increased levels of disaccharidases  The trophic effect of S. Boulardii on enterocytes lead to trigger of increased levels of disaccharides such as lactose , maltase, and sucrase.
  6. 6. Saccharomyces boulardii probiotic Medicinal Uses 1. Food allergies  This comes useful in neonates and infants who are diagnosed with leaky gut syndrome by preventing the allergic reactions to certain food antigens. 2. Immunity  Triggers both innate (first line of defense) as well as adaptive (antibodies action) to respond to infections caused by pathogens 3. Nutrient absorption and digestion  S. Boulardii enables the body to produce enzymes (e.g. Lactase for lactose), which are important for enhanced electrolyte and nutrient absorption.
  7. 7. Saccharomyces boulardii probiotic Medicinal Uses 4. Intestinal health  Improves and protects the integrity of the intestinal mucosa. It also creates substances which are necessary to nourish the colon cells as well as its normal flora. 5. Inflammatory Bowel Disease  This yeast specie may have a beneficial effect in the treatment of IBD in vivo (mice) In a study conducted, it was discovered that it limits the inflammatory response of the colon’s immune cells to pathogens.  Blocks the chemical secretion that leads to inflammation  Also, in a trial conducted, it has been found to aid in remission of ulcerative colitis.  Promotes fewer relapses in patients with Crohn’s Disease.
  8. 8. Saccharomyces boulardii probiotic Medicinal Uses 6. Infections  Prevents the GI infections caused by agents such as C.dificile, E.coli and Candida albicans.  Inhibits the harmful effects of Candida to the spleen kidneys, and lymph nodes, in mices.  Responsible for reduction in the growth of C. albicans, E. coli, Shigella, Salmonella typhimurium, Pseudomonas aeruginosa, Staphylococcus aureus, and Entamoeba histolytica. 7. Diarrhea  Plays a significant role in the prevention of traveller’s diarrhea and antibiotic-associated diarrhea.
  9. 9. Saccharomyces boulardii probiotic Side Effects and Safety  In most adults, S. Boulardii is more likely safe when consumed by mouth. However, there are cases in which it may cause gas. Also, fungal infections which can spread through the bloodstream happens rarely.  In children, it is considered to be possibly safe. Although that is the case, it is still best to ask for the doctor’s advise.
  10. 10. Saccharomyces boulardii probiotic Side Effects and Safety  There is not much study proving the safety of S. Boulardii intake in pregnant women. Again, consultation with the doctor is advised.  Use of S. Boulardii in people with weakened immune system still holds concern over the healthcare professionals. This is because these people have increased risk of the yeast infection that can spread through the blood stream (fungemia).  People with yeast-containing products are advised to refrain from its use
  11. 11. Saccharomyces boulardii probiotic Dosage  For healthy people: Gradually consume 3 capsules      twice a day. In the first week, take 1 capsule. In the second week, have 2 capsules Then, in the third week, consume 3 capsules. This is to prevent the die off effect. For antibiotic-associated diarrhea: 250-500 mg 2-4x daily Clostridium difficile-caused diarrhea: 1g daily taken for 4 weeks together with the antibiotic treatment. Ulcerative colitis: 205mg 3x daily Infections caused H. Pylori: A dose of 5 billion CFUs of S. Boulardii everyday Crohn’s disease: 250 mg of 3x daily for up to 9 weeks. Also, 1 gram daily combined with the usual treatment
  12. 12. My Favorite Probiotic  Probacto is the best probiotic that I have ever run into. They use multiple strains and they are spore forming so they can last while not refrigerated. They do not use cheap bacteria, but expensive ones such as B. Subtilis, and also contain S. Boulardii  Probacto also contains prebiotics to help stimulate the growth of beneficial bacteria in your gut.  Probacto contains digestive enzymes to assist in cleaning out your yeast.  Probacto is enteric coated and made to be slow release so it will release in your gut gradually.
  13. 13. Conclusion  The use of Saccharomyces boulardii as a probiotic has its advantages and disadvantages. It has many advantages that specifically addresses the problems of the digestive system such as diarrhea, Crohn’s disease, and ulcerative colitis. Proper dosing should be remembered whenever it is consumed to prevent the “die-off effect”. However, its use, particularly in people with compromised immune system, should be carefully considered because it may potentially harm the body such as in the case of the spread of fungal infection through the bloodstream. This is a very life-threatening condition. So, it should be used with caution everytime.