1. © 2016 - All rights reserved.
Reversing the Invisible Epidemic of
Autoimmune Disease
DIY Comes to Autoimmunity
Your Autoimmunity Connection
+1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360

2. © 2016 - All rights reserved.
My Role: A=acking the Autoimmune Epidemic
A huge, growing and untapped market opportunity > CVD + Cancer
Obscured by staLsLcal gaps, scaMered across mulLple body parts and specialLes
A big, expensive, underappreciated part of the chronic disease epidemic
The @me is now to tackle this invisible epidemic!
DrBonnie360’s Services
• Converging science, technology, paLent demand
• New R&D: -omics, immunology, systems biology, root-cause
• IT infrastructure: ubiquitous smart mobile, API/Cloud, WWW
• Emerging autoimmune communiLes, demand (e.g. diet)
• Emerging technology pla_orms
• Point soluLons in diabetes and obesity show how lifestyle
modificaLons can improve quality of life and save money.
• New pla_orms, portals, communiLes are beginning to scale
health, wellness and prevenLon.
• Advances in technology provide tools to improve care delivery
Corporate Strategy
Business Development
Community Development
CommunicaLons & Design
MarkeLng & Sales

3. © 2016 - All rights reserved.
Huge & Growing Unmet Need
50 Million (16%)
Americans with
Autoimmune Diseases
• 1 in 6 Americans
• PopulaLon of 25 states
• > CVD + Cancer
100 +
autoimmune diseases
A Top 10
cause of death in
women < 64 yo
IBD incidence
Doubled
children < 10 yo
(1991-2002 )

4. © 2016 - All rights reserved.
Under-Recognized & Under-Researched:
16%
10%
6%
68%
US Pa@ent Popula@on
6%
24%
37%
33%
2014 NIH Grant Alloca@ons
Autoimmune Disease
Cardiovascular Disease
Cancer
Other

5. © 2016 - All rights reserved.
Untapped Market Opportuni@es
By 2023,
230 Million
Americans with chronic
diseases, cosLng
$4.2 Trillion
total treatment plus
economic output
$8/10
spent on health care
goes to chronic
diseases
27%
children <19 have at
least one chronic
condiLon
7/10 Deaths
Annually due to
chronic diseases
129% Increase
for specialty
autoimmune medicine
from 2011-2015
($20.9B – $47.9B)

6. © 2016 - All rights reserved.
Opportunity for Individualized Autoimmune Medicine NOW
Top-Down Convergence
Advances in technology and science provide tools for digital
individualized medicine:
2016
2015
2014
• Apple, Amazon, Google enter
healthcare market
• # of personal genomics
companies doubled
• Cleveland Clinic opens a
funcLonal medicine center
• Microbiome therapeuLcs
• Immuno-oncology
• Telemedicine & telehealth
• Virtual educaLon & digital
coaching
• IBM Watson, Apple
Healthkit
• AcLve M&A point
soluLons to pla_orms
• Cleveland Clinic begins
outcomes/cost clinical
trials
• Wellness as a Service

7. © 2016 - All rights reserved.
Need Individualized Autoimmune Medicine NOW
BoMom-Up Convergence
Autoimmune paLents desperately seeking earlier diagnoses
and sustainable treatments that address root causes
• Gaps in diagnosis & treatment
• Average: 3.5 years & 5 doctors to Dx
• 51% labeled chronic complainers
• More autoimmune than cancer
paLents with poor quality of life
• Rheumatoid arthriLs 87% vs.
Breast cancer 39%
Needs Trends
• Crowdsourcing, CiLzen Science and
maker movement
• Online community support groups
& growing paLent power
• QuanLfied Self, N=1 Clinical Trials,
experiments with diet & supplements
• Emergence of FuncLonal Medicine
programs in convenLonal serngs

8. © 2016 - All rights reserved.
-RemoteMonitoring
- Chronic Disease Marketplace/Platform
- Functional and Conventional Coordination
-Personalization
-Individualized
-DataCollection
REGENERATION
Bridging the Gap – Individualized Autoimmune Care

9. © 2016 - All rights reserved.
Contact Us
+1.310.666.5312
drbonnie360@gmail.com
www.drbonnie360.com
@DrBonnie360
www.facebook.com/
YourAutoimmunityConnecLon
Bonnie Feldman, DDS, MBA
DrBonnie360’s mission is to create a
digitally connected world of personalized
care for autoimmune paLents.
We consult with start-up companies and
entrepreneurs who are bringing new
products and services that will improve
research, diagnosis, and treatment for
autoimmunity

10. © 2016 - All rights reserved.
Sources
• Huge & Growing Unmet Need
• 50 Million Americans & 100+ Autoimmune Disease – “Why is Auotoimmune Diseae Underserved,” DrBonnie360, Mar 2015.
hMp://bit.ly/1B57pNb
• Top 10 cause of death – AARDA Autoimmune Disease Fact Sheet. hMp://www.aarda.org/autoimmune-informaLon/
autoimmune-staLsLcs/
• Increasing Incidence in IBD – “Rising Incidence of Inflammatory Bowel Disease among Children: a 12-year Study,” Journal of
Pediatric Gastroenterology & NutriLon, Jan 2010. hMp://bit.ly/1Zeg3b6
• Under-recognized & Under-Researched
• 16% of the US PopulaLon is Autoimmune – AARDA Autoimmune Disease Fact Sheet. hMp://www.aarda.org/autoimmune-
informaLon/autoimmune-staLsLcs/
• <6% of NIH Funding goes to autoimmunity – “Health, United States, 2013 with Special Feature on PrescripLon Drugs,” Center
for Disease Control and PrevenLon, 2014. hMp://www.cdc.gov/nchs/data/hus/hus13.pdf#042
• Untapped Market Opportunity
• 27% of Children – “Chronic Care: Making the Case for Ongoing Care,” Robert Wood Johnson FoundaLon, Mar 2010.
• 7/10 Deaths – “Chronic Disease PrevenLon and Health PromoLon,” Center for Disease Control and PrevenLon, Aug 2016.
• 129% Increase – “Medicines Use and Spending in the U.S: A Review of 2015 and Outlook to 2020,” IMS InsLtute for Healthcare
InformaLcs, Apr 2016.
• $8/10 Dollars – “The Digital RevoluLon comes to US Healthcare,” Goldman Sachs, Jun 2015.
• 230M Americans cosLng $4.2T – “Checkup Time: Chronic Disease and Wellness in America,” Milken InsLtute, Jan 2014.