Pharmaceutical Organic Chemistry Subject out come

1. 1
B. Pharm-IIIrd Semester
Pharmaceutical Organic Chemistry II- Theory
(BP301T)
Dr Arvind Kumar Bharti
Associate Professor
Department of Applied Sciences
AITM, Kanpur

2. 2
Content
1. Scope
2. Objective
3. Course content
4. Unit introduction
5. Practical's discussion
6. Recommended books
Axis Institute of Pharmacy, Kanpur

3. 3
Scope
This subject deals with general methods of preparation and
reaction of some organic compounds.
Reactivity of organic compounds.
Mechanism and orientation of reaction
Chemistry of fats and oils
Axis Institute of Pharmacy, Kanpur

4. 4
Write the structure, name and the type of isomerism of the
organic compounds
Write the reaction, name the reaction and orientation of
reaction
Account for reactivity
Stability of compounds
Prepare organic chemistry
Objective
Axis Institute of Pharmacy, Kanpur

5. 5
Course content
Definition
Types
Classification
Principles
Mechanism
Application
Examples and differences
Axis Institute of Pharmacy, Kanpur

6. Course outcomes (COs)
• CO301.1 To understand about aromaticity, chemistry and reactions
of benzene.
• CO301.2 To understand the concept of hydrolysis, hydrogenation,
Saponification and rancidity of oils.
• CO301.3 To gain knowledge on structure and medicinal uses of
pharmaceutical organic compounds
• CO301.4 To understand the concept of Baeyer’s theory and Sachse
Mohr’s theory.
• CO301.5 To gain knowledge on chemistry of phenols, aromatic
amines and aromatic acids.
• CO301.6 To estimate the analytical constants of fats and oils.
6
Axis Institute of Pharmacy, Kanpur

7. Axis Institute of Technology & Management, Kanpur 7

8. 8
Unit Introduction
Unit-I
Benzene and its derivatives
 Analytical, synthetic and other evidences in the derivation of
structure of benzene
Reactions of benzene
Effect of substituent's on reactivity and orientation of mono
substituted benzene compounds towards electrophilic
substitution reaction.
Structure and uses of DDT, Saccharin, BHC and
Chloramine.
Axis Institute of Pharmacy, Kanpur

9. 9
Phenols
Aromatic Amines
Aromatic Acids
Axis Institute of Pharmacy, Kanpur
Unit-II

10. 10
Fats and oils
Hydrolysis, Hydrogenation, Saponification and
Rancidity of oils, Drying oils.
Analytical constants– Acid value, Saponification value,
Ester value, Iodine value, Acetyl value, Reichert Meissl
(RM) value– significance and principle involved in their
determination.
Axis Institute of Pharmacy, Kanpur
Unit-III

11. 11
Unit-IV
Polynuclear hydrocarbons
Synthesis, reactions Structure and medicinal uses of
Naphthalene
Phenanthrene,
Anthracene
Diphenylmethane
Triphenylmethane and their derivatives.
Axis Institute of Pharmacy, Kanpur

12. 12
Unit-V
Cycloalkanes
Stabilities – Baeyer’s strain theory,
limitation of Baeyer’s strain theory
Coulson and Moffitt’s modification
Sachse Mohr’s theory (Theory of strainless
rings)
Reactions of cyclopropane and cyclobutane
only.
Axis Institute of Pharmacy, Kanpur

13. 13
Practical Discussion
Experiments involving laboratory techniques
 Recrystallization
Steam distillation
Axis Institute of Pharmacy, Kanpur

14. Determination oil Value
14
Acid value
Saponification value
Iodine value
Axis Institute of Pharmacy, Kanpur

15. 15
1. Benzanilide/Phenyl benzoate/Acetanilide from Aniline/
Phenol /Aniline by acylation reaction.
2. 2,4,6-Tribromo aniline/Para bromo acetanilide from
Aniline.
3. Acetanilide by halogenation (Bromination) reaction.
4. 5-Nitro salicylic acid/Meta di nitro benzene from
Salicylic acid / Nitro benzene by nitration reaction.
5. Benzoic acid from Benzyl chloride by oxidation
reaction.
6. Benzoic acid/ Salicylic acid from alkyl benzoate/ alkyl
salicylate by hydrolysis reaction.
Preparation of compounds
Axis Institute of Pharmacy, Kanpur

16. Axis Institute of Pharmacy, Kanpur 16
7. 1-Phenyl azo-2-napthol from Aniline by diazotization
and coupling reactions.
8. Benzil from Benzoin by oxidation reaction.
9. Dibenzal acetone from Benzaldehyde by Claison
Schmidt reaction .
10. Cinnammic acid from Benzaldehyde by Perkin
reaction
11. P-Iodo benzoic acid from P-amino benzoic acid
Preparation of compounds

17. Suggested Books
17
Axis Institute of Pharmacy, Kanpur

18. Thank you
Axis Institute of Pharmacy, Kanpur