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Incremental prognostic value of procedures used to evaluate CAD were compared in men and women. Clinical data, clinical data plus exercise testing results, and clinical data, exercise testing results plus MPI with gated SPECT were evaluated. MPI with gated SPECT had the highest incremental value in both men and women. The incremental value is greater in women than in men. Low-risk women and men were identified equally well, but relatively high-risk women were identified more accurately than relatively high-risk men. Thus, MPI with gated SPECT may play an important role in the clinical assessment and management of CAD in women. 1 1. Hachamovitch R, Berman DS, Kiat H, et al. Effective risk stratification using exercise myocardial perfusion SPECT in women: gender-related differences in prognostic nuclear testing. J Am Coll Cardiol. 1996;28:34-44.
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Estrogen-only arm was also recently discontinued in December 2003 and was associated with a 39% increased risk of stroke (12 excess strokes per 10,000 person years) and 12% significant increased risk of cardiovascular events. JAMA. 2004 Apr 14;291(14):1701-12.