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Postsynaptic  Potentials Lecture 10
Postsynaptic Potentials Signaling in Dendrites & Soma
Postsynaptic Potentials <ul><li>V m  changes </li></ul><ul><ul><li>dendrites & soma </li></ul></ul><ul><li>Excitatory:  + ...
Postsynaptic Potentials - PSPs <ul><li>Chemically-gated ion channels </li></ul><ul><li>Graded </li></ul><ul><ul><li>Summat...
<ul><li>Excitatory Postsynaptic Potential </li></ul><ul><li>Depolarization (+) </li></ul><ul><ul><li>V m  becomes more pos...
<ul><li>Depolarization </li></ul><ul><li>more  likely to fire ~ </li></ul>-65mv - 70mv AT REST V m Time  EPSP + - Record h...
<ul><li>Repeated stimulation </li></ul><ul><li>same synapse ~ </li></ul>-65mv - 70mv AT REST V m Time  Temporal Summation ...
-65mv - 70mv AT REST V m Time  + - Temporal Summation more depolarization +
-65mv - 70mv AT REST V m Time  + - Temporal Summation more depolarization +
<ul><li>Multiple synapses </li></ul>-65mv - 70mv AT REST V m Time  + - Spatial Summation + +
<ul><li>Inhibitory Postsynaptic Potential </li></ul><ul><li>similar to EPSPs </li></ul><ul><ul><li>EXCEPT opposite </li></...
<ul><li>Hyperpolarization </li></ul><ul><li>less  likely to fire </li></ul><ul><li>also summate (max) </li></ul>- 70mv AT ...
EPSPs & IPSPs summate <ul><li>CANCEL EACH OTHER </li></ul><ul><li>Net stimulation  </li></ul><ul><ul><li>EPSPs + IPSPs = n...
- 70mv EPSP IPSP + - - +
Postsynaptic Potentials <ul><li>EPSP </li></ul><ul><ul><li>Excitatory </li></ul></ul><ul><ul><li>Depolarization </li></ul>...
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~BN10 postsynaptic potential.ppt

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~BN10 postsynaptic potential.ppt

  1. 1. Postsynaptic Potentials Lecture 10
  2. 2. Postsynaptic Potentials Signaling in Dendrites & Soma
  3. 3. Postsynaptic Potentials <ul><li>V m changes </li></ul><ul><ul><li>dendrites & soma </li></ul></ul><ul><li>Excitatory: + </li></ul><ul><li>Inhibitory: - ~ </li></ul>
  4. 4. Postsynaptic Potentials - PSPs <ul><li>Chemically-gated ion channels </li></ul><ul><li>Graded </li></ul><ul><ul><li>Summation </li></ul></ul><ul><li>Fast </li></ul><ul><li>Decremental ~ </li></ul>
  5. 5. <ul><li>Excitatory Postsynaptic Potential </li></ul><ul><li>Depolarization (+) </li></ul><ul><ul><li>V m becomes more positive </li></ul></ul><ul><li>Na+ influx ~ </li></ul>EPSPs
  6. 6. <ul><li>Depolarization </li></ul><ul><li>more likely to fire ~ </li></ul>-65mv - 70mv AT REST V m Time EPSP + - Record here +
  7. 7. <ul><li>Repeated stimulation </li></ul><ul><li>same synapse ~ </li></ul>-65mv - 70mv AT REST V m Time Temporal Summation + - +
  8. 8. -65mv - 70mv AT REST V m Time + - Temporal Summation more depolarization +
  9. 9. -65mv - 70mv AT REST V m Time + - Temporal Summation more depolarization +
  10. 10. <ul><li>Multiple synapses </li></ul>-65mv - 70mv AT REST V m Time + - Spatial Summation + +
  11. 11. <ul><li>Inhibitory Postsynaptic Potential </li></ul><ul><li>similar to EPSPs </li></ul><ul><ul><li>EXCEPT opposite </li></ul></ul><ul><li>hyperpolarization (-) </li></ul><ul><ul><li>V m becomes more negative </li></ul></ul><ul><li>K+ efflux ~ </li></ul>IPSPs
  12. 12. <ul><li>Hyperpolarization </li></ul><ul><li>less likely to fire </li></ul><ul><li>also summate (max) </li></ul>- 70mv AT REST V m Time IPSP + - -
  13. 13. EPSPs & IPSPs summate <ul><li>CANCEL EACH OTHER </li></ul><ul><li>Net stimulation </li></ul><ul><ul><li>EPSPs + IPSPs = net effects </li></ul></ul><ul><li>*Integration ~ </li></ul>
  14. 14. - 70mv EPSP IPSP + - - +
  15. 15. Postsynaptic Potentials <ul><li>EPSP </li></ul><ul><ul><li>Excitatory </li></ul></ul><ul><ul><li>Depolarization </li></ul></ul><ul><ul><li>Na+ influx </li></ul></ul><ul><ul><li>AP more likely </li></ul></ul><ul><li>IPSP </li></ul><ul><ul><li>Inhibitory </li></ul></ul><ul><ul><li>Hyperpolarization </li></ul></ul><ul><ul><li>K+ efflux </li></ul></ul><ul><ul><li>AP less likely </li></ul></ul><ul><li>Soma & Dendrites </li></ul><ul><li>Chemically-gated channels </li></ul><ul><li>Passive current </li></ul><ul><li>Graded </li></ul><ul><li>Summation </li></ul>

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