Production of therapeutic glycoproteins -key players, innovators and industry analysis

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A Dolcera Report production about production of therapeutic proteins by glycosylation, major players and technological developments.

The report focuses on technology, industry and patent landscape of the concerned topic.

The Dolcera center of excellence finds about growth of a technology; competition- key players, innovators; gaps and opportunities in the technology and industry with the analyses of patents and trends as the core.

This presentation is a brief introduction to the detailed Dolcera Report on production of therapeutic proteins by glycosylation.

For more details and complete report contact info@dolcera.com

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Production of therapeutic glycoproteins -key players, innovators and industry analysis

  1. 1. Production of Therapeutic Knowledge Services Glycoproteins Production of Therapeuticinfo@dolcera.com Glycoproteins
  2. 2. Like this presentation? This is only a sample report with brief analysis. Purchase the complete report here. Price: $999 Dolcera can provide a comprehensive report customized to your needs Buy the customized report from Dolcera Patent Analytics Services Market Research Services Purchase Patent Dashboard Patent Landscape Services Dolcera Processes Industry Focus Patent Search Services Patent Alerting Services Dolcera Tools Samir Raiyani Email: info@dolcera.com Phone: +1-650-425-6772 Fax: +1-866-690-7517info@dolcera.com Production of Therapeutic 2 Glycoproteins
  3. 3. Contents Production of Therapeutic Glycoproteins Introduction IP search Taxonomy Top Cited Patents Patent to product mapping Key Findings • Major Players • IP Activity • Geographical Activity •Categorization on the basis of production method - Top assignees under each category Technology citation statistics Assignee citation statisticsinfo@dolcera.com Production of Therapeutic 3 Glycoproteins
  4. 4. Introduction • Glycosylation is the attachment of a carbohydrate group to a protein, catalyzed by enzymes called glycosyl transferases. • The majority of clinically approved protein drugs bear some form of post- translational modification, most commonly glycosylation. • Glycosylation is important because it can influence the therapeutic efficacy, immunogenicity, solubility, and in-vivo half life of the glycoprotein. • Glycosylation has been found to occur in a large variety of protein classes, including – but not limited to – antibodies, protein hormones, growth factors, cytokines and vaccines. • Several systems used for the production of proteins in glycosylated form are being explored. Some of these include Mammalian systems like CHO, fungal systems, insects, plants, bacterial systems etc. Glycosylated proteins are also being produced by in vitro means.info@dolcera.com Production of Therapeutic 4 Glycoproteins
  5. 5. TaxonomyA detailed taxonomy ispresented, which wasobtained after a sampleanalysis. It includesvarious hosts, systems,process and utilities ofprotein glycosylation • To see the detailed VVT Taxonomy, mailto: info@dolcera.cominfo@dolcera.com Production of Therapeutic 5 Glycoproteins
  6. 6. Classification • Different classes related to glycosylated therapeutics and production of therapeutics that can be glycosylated are identified. • These Classes are used in the search strategy • To see the detailed classification, mailto: info@dolcera.cominfo@dolcera.com Production of Therapeutic 6 Glycoproteins
  7. 7. Control Patents • Highly relevant patents are used for extracting keywords and ensuring the quality of the search query • To see the detailed table, mailto: info@dolcera.cominfo@dolcera.com Production of Therapeutic 7 Glycoproteins
  8. 8. Search Concepts • Concepts used to search patent literature • Relevant keywords were also translated to French and German to search for French and German language patents • To see the detailed table, mailto: info@dolcera.cominfo@dolcera.com Production of Therapeutic 8 Glycoproteins
  9. 9. IP Search Database: Thomson Innovation Timeline: 01-01-1991 to 30-08-2011 • To see the detailed table, mailto: info@dolcera.cominfo@dolcera.com Production of Therapeutic 9 Glycoproteins
  10. 10. Patent to product mapping • The patens are mapped to the products based on patent focusinfo@dolcera.com Production of Therapeutic 10 Glycoproteins
  11. 11. Dolcera Dashboard • Dolcera dashboard is a web 2.0 technology. It enables dynamic presentation of patent datainfo@dolcera.com Production of Therapeutic 11 Glycoproteins
  12. 12. Insights: Major Players • Roche Holding Ltd, Kirin Holdings Company Limited and Novo Nordisk are the top assignees in the fieldinfo@dolcera.com Production of Therapeutic 12 Glycoproteins
  13. 13. Insights: Key Patents • The key patents in the area are held by University of California, University of Texas, Alko Inc and Bristol-Myers Squibb Co.info@dolcera.com Production of Therapeutic 13 Glycoproteins
  14. 14. Insights: Year wise IP activity • Year wise IP activity based on publication yearsinfo@dolcera.com Production of Therapeutic 14 Glycoproteins
  15. 15. Insights: Year wise IP activity • Year wise IP activity based on priority yearsinfo@dolcera.com Production of Therapeutic 15 Glycoproteins
  16. 16. Insights: Geographical Distribution • Geographical distribution of patentsinfo@dolcera.com Production of Therapeutic 16 Glycoproteins
  17. 17. Insights: Major Player – Mammalian cell lines • Roche holding Ltd., Kirin Holdings Co.Ltd. and Lonza Group AG are active in using mammalian cell linesinfo@dolcera.com Production of Therapeutic 17 Glycoproteins
  18. 18. Insights: Major Player – Transgenic Animals • Abbott Lab. Leads in using transgenic animalsinfo@dolcera.com Production of Therapeutic 18 Glycoproteins
  19. 19. Insights: Major Player - Plants • Dow Chemical Co. and Plant Research International lead in plant systemsinfo@dolcera.com Production of Therapeutic 19 Glycoproteins
  20. 20. Insights: Major Player - Microorganisms • Merck & Co. Inc, Kirin Holdings Co. Ltd. and Novozymes AS lead in microbial systemsinfo@dolcera.com Production of Therapeutic 20 Glycoproteins
  21. 21. Insights: Major Player - Enzymes • Novo Nordisk, Kirin Holdings Co.Ltd. and Roche Holding Ltd. lead in using enzyme systemsinfo@dolcera.com Production of Therapeutic 21 Glycoproteins
  22. 22. Insights: Major Player – Chemical/Cell free synthesis • Novo Nordisk, Roche Holding Ltd. and Otsuka Holding Co. Ltd. lead in chemical/cell free synthesis systemsinfo@dolcera.com Production of Therapeutic 22 Glycoproteins
  23. 23. Insights: Major Player: Fermentation/Culture conditions • Roche Holding Ltd., Pfizer Inc. and Bristol Myers Squibb Co. lead in fermentation/culture conditionsinfo@dolcera.com Production of Therapeutic 23 Glycoproteins
  24. 24. Conclusions• The first generation of biopharmaceuticals manufactured using recombinant technologies was launched in the 1980s, and patents protecting them are now nearing expiration. As with small molecule drugs, the expiration of patents creates an opportunity for generic biologicals to enter the market. Current IP situation allows a new patent protection of the product and the process• CHO is the most preferred system for production of proteins with mammalian type glycosylation.• Due to drawbacks in mammalian systems, active research is on to find alternate production systems for producing glycoproteins. Few such hosts include E.coli, Yeast, Fungi, plants and insect systems.• A few patents also talk on chemical/cell free synthesis for in vitro protein glycosylation.info@dolcera.com Production of Therapeutic 24 Glycoproteins
  25. 25. Like this presentation? This is only a sample report with brief analysis. Purchase the complete report here. Price: $999 Dolcera can provide a comprehensive report customized to your needs Buy the customized report from Dolcera Patent Analytics Services Market Research Services Purchase Patent Dashboard Patent Landscape Services Dolcera Processes Industry Focus Patent Search Services Patent Alerting Services Dolcera Tools Samir Raiyani Email: info@dolcera.com Phone: +1-650-425-6772 Fax: +1-866-690-7517info@dolcera.com Production of Therapeutic 25 Glycoproteins

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