SlideShare a Scribd company logo
1 of 14
Download to read offline
Novel Drug Delivery
System
By- Dipesh Adesh Gamare
ABSTARCT
Drug delivery systems are defined as formulations aiming for transportation of a
drug to the desired area of action within the body. The basic component of drug
delivery systems is an appropriate carrier that protects the drug from rapid
degradation or clearance and thereby enhances drug concentration in target
tissues. Based on their biodegradable, biocompatible, and non-immunogenic
structure, Niosomes are promising drug carriers that are formed by self-
association of nonionic surfactants and cholesterol in an aqueous phase. In
recent years, numerous research articles have been published in scientific
journals reporting the potential of niosomes to serve as a carrier for the delivery
of different types of drugs. The information describes preparation methods, and
recent studies on niosomal drug delivery systems and also gives up to date
information regarding recent applications of niosomes in drug delivery.
INTRODUCTION
Niosomes are one of the promising drug carriers that have a bilayer structure
and are formed by self-association of nonionic surfactants and cholesterol in an
aqueous phase. Niosomes are biodegradable, biocompatible, and
nonimmunogenic. They have long shelf life, exhibit high stability, and enable the
delivery of drug at target site in a controlled and/or sustained manner .
In recent years, the potential of niosomes as a drug carrier has been extensively
studied . Various types of nonionic surfactants have been reported to form
niosomes and enable the entrapment of a large number of drugs with a wide
range of solubility . The composition, size, number of lamellae, and surface
charge of niosomes can be varied and optimized to enhance the performance of
niosomes for drug delivery.
STRUCTURE OF NIOSOME
1.Thin-Film
Hydration
Method (TFH)
2. Ether
Injection
Method (EIM)
3. Reverse Phase
Evaporation
Method (REV)
4. Supercritical
Carbon Dioxide
Fluid (scCO2)
5. Proniosome
6. The “Bubble”
Method
METHODS OF PREPARATION
1.Thin-Film Hydration Method (TFH) 2. Ether Injection Method (EIM)
3. Reverse Phase Evaporation Method (REV)
5. Proniosome
4. Supercritical Carbon Dioxide Fluid (scCO2)
6. The “Bubble” Method
NIOSOMES AS DRUG CARRIERS
• Niosomes are very promising carriers for the delivery of numerous
pharmacological and diagnostic agents. A number of publications have reported
the preparation, characterization, and use of niosomes as drug carriers.
Because of their nonionic nature, they offer excellent biocompatibility and low
toxicity. The unique structure of niosomes allows the development of effective
novel drug delivery systems with ability of loading both hydrophilic and
lipophilic drugs. Hydrophilic drugs and lipophilic drugs are entrapped into the
aqueous core and membrane bilayer of niosome
RECENT STUDY
ANTICANCER DRUG
DELIVERY
TARGETED
DELIVERY
ANTI-VIRAL DRUGS ANTIBIOTICS
APPLICATIONS
OF NDDS
Antibiotics
 Niosomal carriers are also suitable for the delivery of antibiotics and
anti-inflammatory agents. These carriers have been used extensively to
improve poor skin penetration and as well as enhance skin retention of
the drugs.
 Begum and coworkers designed rifampicin, a broad spectrum
antibiotic, encapsulated in a niosomal delivery system.
 They investigated the activity of this system in in vitro conditions and
this study showed that niosomal formulation of rifampicin is able to
provide consistent and prolonged release of the drug.
Antiviral Drugs
 Zidovudine, which is the first anti-HIV compound approved for clinical use,
encapsulated niosomes, and examined their entrapment efficiency and as well as
sustainability of release.
 The niosomes were formulated by combining the proportions of Tween, Span, and
cholesterol. Niosomes composed Tween 80 entrapped large amounts of zidovudine and
the addition of dicetyl phosphate enhanced drug release for a longer time .
 The drug leakage from Tween 80 formulations stored at room temperature was
significant compared to niosomes stored at 4°C for 90 days.
 Besides, the results of a pharmacokinetic study in rabbits also confirmed that Tween
80 formulations with dicetyl phosphate were cleared from the circulation within five
hours .
CONCLUSION
Niosomes are novel nano drug carriers to design effective drug delivery systems.
They offer a great opportunity for loading hydrophilic, lipophilic drugs, or both
drugs together. Numbers of studies have been performed with different types of
niosomes in delivery of the anticancer agents, anti-inflammatory agents, anti-
infective agents, and so forth.
The relevant studies demonstrated that niosomes improve the stability of the
entrapped drug, reduce the dose, and enable targeted delivery to a specific type of
tissue. The structural properties and characteristics of the niosomes can be
enhanced by using novel preparations, loading, and modification methods for
particular routes of administration. Thus, niosomes present itself as promising
tools in commercially available therapeutics.
REFERENCE :https://www.hindawi.com/journals/jnm/2016/7372306
Novel Drug Delivery System PPT(Niosomes).pptx

More Related Content

Similar to Novel Drug Delivery System PPT(Niosomes).pptx

APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptx
APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptxAPPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptx
APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptxTanvi Mhashakhetri
 
Advances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdf
Advances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdfAdvances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdf
Advances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdftabindakiran20feb
 
NIOSOMES – A NOVEL DRUG DELIVERY SYSTEM
NIOSOMES – A NOVEL DRUG DELIVERY SYSTEMNIOSOMES – A NOVEL DRUG DELIVERY SYSTEM
NIOSOMES – A NOVEL DRUG DELIVERY SYSTEMAbhishekPatil387
 
Novel drug delivery system
Novel drug delivery system Novel drug delivery system
Novel drug delivery system Khan Ramiz
 
Nanotechnology based drug delivery
Nanotechnology based drug deliveryNanotechnology based drug delivery
Nanotechnology based drug deliveryPravin Chinchole
 
Niosome Formulation And Evaluations .pdf
Niosome Formulation And Evaluations .pdfNiosome Formulation And Evaluations .pdf
Niosome Formulation And Evaluations .pdfRAHUL PAL
 
Niosomes (Formulation and evaluation).pptx
Niosomes (Formulation and evaluation).pptxNiosomes (Formulation and evaluation).pptx
Niosomes (Formulation and evaluation).pptxPrachi Pandey
 
Niosomes and Aquasomes
Niosomes and AquasomesNiosomes and Aquasomes
Niosomes and AquasomesSyed Imran
 
The Novel Drug Delivery System.pptx
The Novel Drug Delivery System.pptxThe Novel Drug Delivery System.pptx
The Novel Drug Delivery System.pptxAbhishek Borkar15
 
Nano-niosomes in drug, vaccine and gene delivery: a rapid overview
Nano-niosomes in drug, vaccine and gene delivery: a rapid overviewNano-niosomes in drug, vaccine and gene delivery: a rapid overview
Nano-niosomes in drug, vaccine and gene delivery: a rapid overviewNanomedicine Journal (NMJ)
 
Niosome
Niosome Niosome
Niosome Roshan5
 
Nanotechnology and its applications
Nanotechnology and its applicationsNanotechnology and its applications
Nanotechnology and its applicationsAyushi Maheshwari
 
Nanoparticulate drug delivery system : recent advances
Nanoparticulate drug delivery system : recent advancesNanoparticulate drug delivery system : recent advances
Nanoparticulate drug delivery system : recent advancesGayatriTiwaskar
 
NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...
NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...
NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...SriramNagarajan17
 
Nanosponge: Versatile Drug Delivery System
Nanosponge: Versatile Drug Delivery SystemNanosponge: Versatile Drug Delivery System
Nanosponge: Versatile Drug Delivery Systembiniyapatel
 
PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,
PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,
PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,AVIJIT BAKSHI
 

Similar to Novel Drug Delivery System PPT(Niosomes).pptx (20)

APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptx
APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptxAPPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptx
APPLICATIONS OF NIOSOMES IN DRUG DELIVERY SYSTEM.pptx
 
Advances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdf
Advances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdfAdvances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdf
Advances_of_Non-Ionic_Surfactant_Vesicles_Niosomes.pdf
 
NIOSOMES – A NOVEL DRUG DELIVERY SYSTEM
NIOSOMES – A NOVEL DRUG DELIVERY SYSTEMNIOSOMES – A NOVEL DRUG DELIVERY SYSTEM
NIOSOMES – A NOVEL DRUG DELIVERY SYSTEM
 
Formulation and Evaluation of Atorvastatin Calcium Niosomes
Formulation and Evaluation of Atorvastatin Calcium NiosomesFormulation and Evaluation of Atorvastatin Calcium Niosomes
Formulation and Evaluation of Atorvastatin Calcium Niosomes
 
Novel drug delivery system
Novel drug delivery system Novel drug delivery system
Novel drug delivery system
 
Nanotechnology based drug delivery
Nanotechnology based drug deliveryNanotechnology based drug delivery
Nanotechnology based drug delivery
 
Niosome seminar
Niosome seminarNiosome seminar
Niosome seminar
 
Niosome Formulation And Evaluations .pdf
Niosome Formulation And Evaluations .pdfNiosome Formulation And Evaluations .pdf
Niosome Formulation And Evaluations .pdf
 
Niosomes (Formulation and evaluation).pptx
Niosomes (Formulation and evaluation).pptxNiosomes (Formulation and evaluation).pptx
Niosomes (Formulation and evaluation).pptx
 
Niosomes and Aquasomes
Niosomes and AquasomesNiosomes and Aquasomes
Niosomes and Aquasomes
 
The Novel Drug Delivery System.pptx
The Novel Drug Delivery System.pptxThe Novel Drug Delivery System.pptx
The Novel Drug Delivery System.pptx
 
Nano-niosomes in drug, vaccine and gene delivery: a rapid overview
Nano-niosomes in drug, vaccine and gene delivery: a rapid overviewNano-niosomes in drug, vaccine and gene delivery: a rapid overview
Nano-niosomes in drug, vaccine and gene delivery: a rapid overview
 
vesular dds
vesular ddsvesular dds
vesular dds
 
Niosome
Niosome Niosome
Niosome
 
Nanotechnology and its applications
Nanotechnology and its applicationsNanotechnology and its applications
Nanotechnology and its applications
 
Nanoparticulate drug delivery system : recent advances
Nanoparticulate drug delivery system : recent advancesNanoparticulate drug delivery system : recent advances
Nanoparticulate drug delivery system : recent advances
 
NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...
NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...
NIOSOMES (NON IONIC SURFACTANT VESICLES) PREPARATION AND STABILITY IN BIOLOGI...
 
Nanosponge: Versatile Drug Delivery System
Nanosponge: Versatile Drug Delivery SystemNanosponge: Versatile Drug Delivery System
Nanosponge: Versatile Drug Delivery System
 
PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,
PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,
PARENTERAL CONTROLLED DRUG DELIVERY SYSTEMS,
 
NIOSOMES ppt.
NIOSOMES ppt.NIOSOMES ppt.
NIOSOMES ppt.
 

More from DipeshGamare

GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...
GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...
GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...DipeshGamare
 
IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...
IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...
IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...DipeshGamare
 
Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptx
Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptxTheories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptx
Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptxDipeshGamare
 
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptx
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptxSELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptx
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptxDipeshGamare
 
cell injury morphology.pptx
 cell injury morphology.pptx cell injury morphology.pptx
cell injury morphology.pptxDipeshGamare
 
etiology or causes of cell injury.pptx
etiology or causes of cell injury.pptxetiology or causes of cell injury.pptx
etiology or causes of cell injury.pptxDipeshGamare
 
Anatomy Of Lungs.pptx
Anatomy Of Lungs.pptxAnatomy Of Lungs.pptx
Anatomy Of Lungs.pptxDipeshGamare
 
CALIBRATION METHODS OF APPARATUS IN LABORTORY.pptx
CALIBRATION METHODS OF APPARATUS IN LABORTORY.pptxCALIBRATION METHODS OF APPARATUS IN LABORTORY.pptx
CALIBRATION METHODS OF APPARATUS IN LABORTORY.pptxDipeshGamare
 
RADIOPHARMACEUTICALS.pptx
RADIOPHARMACEUTICALS.pptxRADIOPHARMACEUTICALS.pptx
RADIOPHARMACEUTICALS.pptxDipeshGamare
 
water_pollution.ppt
water_pollution.pptwater_pollution.ppt
water_pollution.pptDipeshGamare
 
Therapeutic drug monitoring- Descriptive questions and answers.docx
Therapeutic drug monitoring- Descriptive questions and answers.docxTherapeutic drug monitoring- Descriptive questions and answers.docx
Therapeutic drug monitoring- Descriptive questions and answers.docxDipeshGamare
 
Therapeutic Drug Monitoring.pptx
Therapeutic Drug Monitoring.pptxTherapeutic Drug Monitoring.pptx
Therapeutic Drug Monitoring.pptxDipeshGamare
 
Transfer from R & D to production.pptx
Transfer from R & D to production.pptxTransfer from R & D to production.pptx
Transfer from R & D to production.pptxDipeshGamare
 
Size Separation.pptx
Size Separation.pptxSize Separation.pptx
Size Separation.pptxDipeshGamare
 
METHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptx
METHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptxMETHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptx
METHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptxDipeshGamare
 
CLASSIFICATION OF CRUDE DRUGS.pptx
CLASSIFICATION OF CRUDE DRUGS.pptxCLASSIFICATION OF CRUDE DRUGS.pptx
CLASSIFICATION OF CRUDE DRUGS.pptxDipeshGamare
 

More from DipeshGamare (16)

GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...
GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...
GAS CHROMATOGRAPHY-Principle, Instrumentation Advantage and disadvantage appl...
 
IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...
IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...
IR SPECTROCOPY, Instrumentation of IR spectroscopy, Application of IR spectro...
 
Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptx
Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptxTheories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptx
Theories of dispersion, pharmaceutical dispersion (Emulsion and suspension).pptx
 
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptx
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptxSELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptx
SELF-EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS).pptx
 
cell injury morphology.pptx
 cell injury morphology.pptx cell injury morphology.pptx
cell injury morphology.pptx
 
etiology or causes of cell injury.pptx
etiology or causes of cell injury.pptxetiology or causes of cell injury.pptx
etiology or causes of cell injury.pptx
 
Anatomy Of Lungs.pptx
Anatomy Of Lungs.pptxAnatomy Of Lungs.pptx
Anatomy Of Lungs.pptx
 
CALIBRATION METHODS OF APPARATUS IN LABORTORY.pptx
CALIBRATION METHODS OF APPARATUS IN LABORTORY.pptxCALIBRATION METHODS OF APPARATUS IN LABORTORY.pptx
CALIBRATION METHODS OF APPARATUS IN LABORTORY.pptx
 
RADIOPHARMACEUTICALS.pptx
RADIOPHARMACEUTICALS.pptxRADIOPHARMACEUTICALS.pptx
RADIOPHARMACEUTICALS.pptx
 
water_pollution.ppt
water_pollution.pptwater_pollution.ppt
water_pollution.ppt
 
Therapeutic drug monitoring- Descriptive questions and answers.docx
Therapeutic drug monitoring- Descriptive questions and answers.docxTherapeutic drug monitoring- Descriptive questions and answers.docx
Therapeutic drug monitoring- Descriptive questions and answers.docx
 
Therapeutic Drug Monitoring.pptx
Therapeutic Drug Monitoring.pptxTherapeutic Drug Monitoring.pptx
Therapeutic Drug Monitoring.pptx
 
Transfer from R & D to production.pptx
Transfer from R & D to production.pptxTransfer from R & D to production.pptx
Transfer from R & D to production.pptx
 
Size Separation.pptx
Size Separation.pptxSize Separation.pptx
Size Separation.pptx
 
METHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptx
METHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptxMETHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptx
METHODS OF DETERMINATION OF CONFIGURATION OF GEOMETRICAL ISOMERS.pptx
 
CLASSIFICATION OF CRUDE DRUGS.pptx
CLASSIFICATION OF CRUDE DRUGS.pptxCLASSIFICATION OF CRUDE DRUGS.pptx
CLASSIFICATION OF CRUDE DRUGS.pptx
 

Recently uploaded

Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)
Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)
Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)MohamadAlhes
 
Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...
Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...
Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...Dr. Dheeraj Kumar
 
Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...
Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...
Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...Badalona Serveis Assistencials
 
Introduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali RaiIntroduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali RaiGoogle
 
PNEUMOTHORAX AND ITS MANAGEMENTS.pdf
PNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdfPNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdf
PNEUMOTHORAX AND ITS MANAGEMENTS.pdfDolisha Warbi
 
Presentation on General Anesthetics pdf.
Presentation on General Anesthetics pdf.Presentation on General Anesthetics pdf.
Presentation on General Anesthetics pdf.Prerana Jadhav
 
Chronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptx
Chronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptxChronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptx
Chronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptxSasikiranMarri
 
ANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom KidanemariamANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom KidanemariamAkebom Gebremichael
 
Role of medicinal and aromatic plants in national economy PDF.pdf
Role of medicinal and aromatic plants in national economy PDF.pdfRole of medicinal and aromatic plants in national economy PDF.pdf
Role of medicinal and aromatic plants in national economy PDF.pdfDivya Kanojiya
 
History and Development of Pharmacovigilence.pdf
History and Development of Pharmacovigilence.pdfHistory and Development of Pharmacovigilence.pdf
History and Development of Pharmacovigilence.pdfSasikiranMarri
 
Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!ibtesaam huma
 
Music Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara Rajendran
Music Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara RajendranMusic Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara Rajendran
Music Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara RajendranTara Rajendran
 
PHYSIOTHERAPY IN HEART TRANSPLANTATION..
PHYSIOTHERAPY IN HEART TRANSPLANTATION..PHYSIOTHERAPY IN HEART TRANSPLANTATION..
PHYSIOTHERAPY IN HEART TRANSPLANTATION..AneriPatwari
 
Big Data Analysis Suggests COVID Vaccination Increases Excess Mortality Of ...
Big Data Analysis Suggests COVID  Vaccination Increases Excess Mortality Of  ...Big Data Analysis Suggests COVID  Vaccination Increases Excess Mortality Of  ...
Big Data Analysis Suggests COVID Vaccination Increases Excess Mortality Of ...sdateam0
 
Presentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptx
Presentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptxPresentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptx
Presentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptxpdamico1
 
METHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaur
METHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaurMETHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaur
METHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaurNavdeep Kaur
 
Plant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdfPlant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdfDivya Kanojiya
 
Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...
Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...
Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...Wessex Health Partners
 
SGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdf
SGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdfSGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdf
SGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdfHongBiThi1
 

Recently uploaded (20)

Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)
Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)
Myelin Oligodendrocyte Glycoprotein antibody associated disease (MOGAD)
 
JANGAMA VISHA .pptx-
JANGAMA VISHA .pptx-JANGAMA VISHA .pptx-
JANGAMA VISHA .pptx-
 
Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...
Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...
Units of Radiation Measurements, Quality Specification, Half-Value Thickness,...
 
Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...
Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...
Presentació "Real-Life VR Integration for Mild Cognitive Impairment Rehabilit...
 
Introduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali RaiIntroduction to Sports Injuries by- Dr. Anjali Rai
Introduction to Sports Injuries by- Dr. Anjali Rai
 
PNEUMOTHORAX AND ITS MANAGEMENTS.pdf
PNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdfPNEUMOTHORAX   AND  ITS  MANAGEMENTS.pdf
PNEUMOTHORAX AND ITS MANAGEMENTS.pdf
 
Presentation on General Anesthetics pdf.
Presentation on General Anesthetics pdf.Presentation on General Anesthetics pdf.
Presentation on General Anesthetics pdf.
 
Chronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptx
Chronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptxChronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptx
Chronic-Fatigue-Syndrome-CFS-Understanding-a-Complex-Disorder.pptx
 
ANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom KidanemariamANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
ANEMIA IN PREGNANCY by Dr. Akebom Kidanemariam
 
Role of medicinal and aromatic plants in national economy PDF.pdf
Role of medicinal and aromatic plants in national economy PDF.pdfRole of medicinal and aromatic plants in national economy PDF.pdf
Role of medicinal and aromatic plants in national economy PDF.pdf
 
History and Development of Pharmacovigilence.pdf
History and Development of Pharmacovigilence.pdfHistory and Development of Pharmacovigilence.pdf
History and Development of Pharmacovigilence.pdf
 
Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!Biomechanics- Shoulder Joint!!!!!!!!!!!!
Biomechanics- Shoulder Joint!!!!!!!!!!!!
 
Music Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara Rajendran
Music Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara RajendranMusic Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara Rajendran
Music Therapy's Impact in Palliative Care| IAPCON2024| Dr. Tara Rajendran
 
PHYSIOTHERAPY IN HEART TRANSPLANTATION..
PHYSIOTHERAPY IN HEART TRANSPLANTATION..PHYSIOTHERAPY IN HEART TRANSPLANTATION..
PHYSIOTHERAPY IN HEART TRANSPLANTATION..
 
Big Data Analysis Suggests COVID Vaccination Increases Excess Mortality Of ...
Big Data Analysis Suggests COVID  Vaccination Increases Excess Mortality Of  ...Big Data Analysis Suggests COVID  Vaccination Increases Excess Mortality Of  ...
Big Data Analysis Suggests COVID Vaccination Increases Excess Mortality Of ...
 
Presentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptx
Presentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptxPresentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptx
Presentation for Bella Mahl 2024-03-28-24-MW-Overview-Bella.pptx
 
METHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaur
METHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaurMETHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaur
METHODS OF ACQUIRING KNOWLEDGE IN NURSING.pptx by navdeep kaur
 
Plant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdfPlant Fibres used as Surgical Dressings PDF.pdf
Plant Fibres used as Surgical Dressings PDF.pdf
 
Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...
Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...
Wessex Health Partners Wessex Integrated Care, Population Health, Research & ...
 
SGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdf
SGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdfSGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdf
SGK HÓA SINH ENZYM 2006 CHỊ THU RẤT HAY.pdf
 

Novel Drug Delivery System PPT(Niosomes).pptx

  • 1. Novel Drug Delivery System By- Dipesh Adesh Gamare
  • 2. ABSTARCT Drug delivery systems are defined as formulations aiming for transportation of a drug to the desired area of action within the body. The basic component of drug delivery systems is an appropriate carrier that protects the drug from rapid degradation or clearance and thereby enhances drug concentration in target tissues. Based on their biodegradable, biocompatible, and non-immunogenic structure, Niosomes are promising drug carriers that are formed by self- association of nonionic surfactants and cholesterol in an aqueous phase. In recent years, numerous research articles have been published in scientific journals reporting the potential of niosomes to serve as a carrier for the delivery of different types of drugs. The information describes preparation methods, and recent studies on niosomal drug delivery systems and also gives up to date information regarding recent applications of niosomes in drug delivery.
  • 3. INTRODUCTION Niosomes are one of the promising drug carriers that have a bilayer structure and are formed by self-association of nonionic surfactants and cholesterol in an aqueous phase. Niosomes are biodegradable, biocompatible, and nonimmunogenic. They have long shelf life, exhibit high stability, and enable the delivery of drug at target site in a controlled and/or sustained manner . In recent years, the potential of niosomes as a drug carrier has been extensively studied . Various types of nonionic surfactants have been reported to form niosomes and enable the entrapment of a large number of drugs with a wide range of solubility . The composition, size, number of lamellae, and surface charge of niosomes can be varied and optimized to enhance the performance of niosomes for drug delivery.
  • 5. 1.Thin-Film Hydration Method (TFH) 2. Ether Injection Method (EIM) 3. Reverse Phase Evaporation Method (REV) 4. Supercritical Carbon Dioxide Fluid (scCO2) 5. Proniosome 6. The “Bubble” Method METHODS OF PREPARATION
  • 6. 1.Thin-Film Hydration Method (TFH) 2. Ether Injection Method (EIM) 3. Reverse Phase Evaporation Method (REV)
  • 7. 5. Proniosome 4. Supercritical Carbon Dioxide Fluid (scCO2) 6. The “Bubble” Method
  • 8. NIOSOMES AS DRUG CARRIERS • Niosomes are very promising carriers for the delivery of numerous pharmacological and diagnostic agents. A number of publications have reported the preparation, characterization, and use of niosomes as drug carriers. Because of their nonionic nature, they offer excellent biocompatibility and low toxicity. The unique structure of niosomes allows the development of effective novel drug delivery systems with ability of loading both hydrophilic and lipophilic drugs. Hydrophilic drugs and lipophilic drugs are entrapped into the aqueous core and membrane bilayer of niosome
  • 11. Antibiotics  Niosomal carriers are also suitable for the delivery of antibiotics and anti-inflammatory agents. These carriers have been used extensively to improve poor skin penetration and as well as enhance skin retention of the drugs.  Begum and coworkers designed rifampicin, a broad spectrum antibiotic, encapsulated in a niosomal delivery system.  They investigated the activity of this system in in vitro conditions and this study showed that niosomal formulation of rifampicin is able to provide consistent and prolonged release of the drug.
  • 12. Antiviral Drugs  Zidovudine, which is the first anti-HIV compound approved for clinical use, encapsulated niosomes, and examined their entrapment efficiency and as well as sustainability of release.  The niosomes were formulated by combining the proportions of Tween, Span, and cholesterol. Niosomes composed Tween 80 entrapped large amounts of zidovudine and the addition of dicetyl phosphate enhanced drug release for a longer time .  The drug leakage from Tween 80 formulations stored at room temperature was significant compared to niosomes stored at 4°C for 90 days.  Besides, the results of a pharmacokinetic study in rabbits also confirmed that Tween 80 formulations with dicetyl phosphate were cleared from the circulation within five hours .
  • 13. CONCLUSION Niosomes are novel nano drug carriers to design effective drug delivery systems. They offer a great opportunity for loading hydrophilic, lipophilic drugs, or both drugs together. Numbers of studies have been performed with different types of niosomes in delivery of the anticancer agents, anti-inflammatory agents, anti- infective agents, and so forth. The relevant studies demonstrated that niosomes improve the stability of the entrapped drug, reduce the dose, and enable targeted delivery to a specific type of tissue. The structural properties and characteristics of the niosomes can be enhanced by using novel preparations, loading, and modification methods for particular routes of administration. Thus, niosomes present itself as promising tools in commercially available therapeutics. REFERENCE :https://www.hindawi.com/journals/jnm/2016/7372306