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CREATINE PHOSPHATE
By- Dipesh Gamare
Formation of Creatine phosphate
 Creatine, or methyl guanidine-acetic acid, is an endogenously formed (made within the organism during
natural metabolic processes) molecule that is stored largely in skeletal muscle, in both free and
phosphorylated forms.
 The phosphorylated form of creatine is appropriately termed phosphocreatine or creatine phosphate.
 Because of its abundance in these tissues, it is not surprising that people who consume non-vegetarian
foods subsequently consume larger quantities of creatine, which can be digested and stored in their own
muscles.
 In skeletal muscle, the concentration of creatine is approximately 125 mmol/kg dm. Of note, creatine is
also found in the brain, liver, kidney, and testes in much smaller quantities.
Role of Creatine Phosphate
1.Creatine Phosphate acts as intermediate store of Phosphate to rephosphorylate ADP
to ATP until metabolic activity increase in the response to increased demand for muscle
contraction.
2.This means that the concentration ATP remains almost Contact; but creatine
Phosphate is depleted After the muscle contraction cease or when the rate of oxidation
of metabolic fuels has increased sufficiently, creatine will be phosphorylation to
creatine phosphate.
3.Creatine Phosphate also acts to shuttle Phosphate from the site of ATP formation to
sites in the cell where it is required for muscle contraction.
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CREATINE PHOSPHATE.pptx

  • 2. Formation of Creatine phosphate  Creatine, or methyl guanidine-acetic acid, is an endogenously formed (made within the organism during natural metabolic processes) molecule that is stored largely in skeletal muscle, in both free and phosphorylated forms.  The phosphorylated form of creatine is appropriately termed phosphocreatine or creatine phosphate.  Because of its abundance in these tissues, it is not surprising that people who consume non-vegetarian foods subsequently consume larger quantities of creatine, which can be digested and stored in their own muscles.  In skeletal muscle, the concentration of creatine is approximately 125 mmol/kg dm. Of note, creatine is also found in the brain, liver, kidney, and testes in much smaller quantities.
  • 3. Role of Creatine Phosphate 1.Creatine Phosphate acts as intermediate store of Phosphate to rephosphorylate ADP to ATP until metabolic activity increase in the response to increased demand for muscle contraction. 2.This means that the concentration ATP remains almost Contact; but creatine Phosphate is depleted After the muscle contraction cease or when the rate of oxidation of metabolic fuels has increased sufficiently, creatine will be phosphorylation to creatine phosphate. 3.Creatine Phosphate also acts to shuttle Phosphate from the site of ATP formation to sites in the cell where it is required for muscle contraction.