Multidisciplinary analysis and optimization under uncertainty
phd thesis presentation
1. Slide 1
Measurement data analysis in quality
management systems.
Application to fuel test methods.
PhD Thesis
of
Dimitrios G. Theodorou
October 2015
NATIONAL TECHNICAL UNIVERSITY OF ATHENS
School οf Chemical Engineering
Department οf Synthesis and
Development οf Industrial Processes
2. Slide 2PhD Thesis – D. Theodorou
Presentation Outline
Introduction and motivation
Statistical and numerical methods overview
Measurement uncertainty arising from sampling
Measurement uncertainty estimation of an analytical
procedure
Estimation of the standard uncertainty of a calibration
curve
The use of measurement uncertainty and precision data
in conformity assessment
Conclusions
3. Slide 3PhD Thesis – D. Theodorou
Introduction and motivation
Fuels produced and placed on market should comply with
strict requirements introduced by relevant legislation
Directive 98/70/EC
Directive 2003/17/EC
Several laboratory test methods are used for the
evaluation and assessment of fuel properties
The social and economic impact of the laboratory getting
a wrong result and the customer consequently
reaching a false conclusion can be enormous.
The laboratory should provide a high quality service to
its customers
4. Slide 4PhD Thesis – D. Theodorou
Introduction and motivation
Quality = Fitness for purpose (i.e. intended use)
The quality of a result and its fitness for purpose is
directly related to the estimation of measurement
uncertainty
Measurement uncertainty – A key requirement for
accreditation according to international standards:
ISO/IEC 17025, for testing and calibration laboratories
ISO 15189, for medical laboratories
ISO/IEC 17043, for proficiency testing providers
ISO Guide 34, for reference material producers
6. Slide 6PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Measurement Uncertainty (MU) = non-negative
parameter characterizing the dispersion of the quantity
values being attributed to a measurand, based on the
information used.
International Vocabulary of Metrology (VIM)
7. Slide 7PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Master document
on MU estimation
Guide to the
Expression of
Uncertainty in
Measurement,
GUM
All MU estimation
methodologies should give
results consistent with
GUM
8. Slide 8PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Modelling approach – GUM uncertainty framework
9. Slide 9PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Modelling approach – GUM uncertainty framework
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10. Slide 10PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Modelling approach – Kragten approximation
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11. Slide 11PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Modelling approach – Monte Carlo Method
12. Slide 12PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Empirical approaches
Data produced by single laboratory validation approach
and analyzed by
ANOVA
Robust ANOVA
Range statistics
Data obtained by proficiency testing schemes
Standard uncertainty estimated as pooled reproducibility limit
Bayesian uncertainty analysis
Type A uncertainty evaluated through a Bayesian
approach
13. Slide 13PhD Thesis – D. Theodorou
Statistical and numerical methods overview
Measurement uncertainty and precision data are used in
conformity assessment
14. Slide 14PhD Thesis – D. Theodorou
Statistical and numerical methods overview
SAMPLING
MEASUREMENT
PROCEDURE
REPORTING
RESULTS AND
ASSESSING
CONFORMITY
Chapter 3
Estimation of sampling
uncertainty
Chapter 4
Estimation of the
uncertainty of a typical
measurement procedure
Chapter 5
Estimation of the
uncertainty of a
measurement procedure
involving the construction
of a calibration curve
Chapter 6
Use of measurement
uncertainty in conformity
assessment
15. Slide 15PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Sampling uncertainty is defined as the part of the total
measurement uncertainty attributable to sampling
Empirical approach
Statistical model
analysissamplingtrue Xx
2
analysis
2
sampling
2
tmeasuremen
2
analysis
2
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2
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16. Slide 16PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Experimental protocol and experimental design
Balanced nested
experimental design
Duplicate diesel samples
were taken from 104
petroleum retail stations
The sampling protocol used was consistent with the standard
method ASTM D 4057
The duplicated samples were analyzed in duplicate under
repeatability conditions for sulful mass content
determination. (ANTEK 9000S sulfur analyzer - ASTM D 5453
/ISO 20846)
Sampling
target
Sample B
Sample A
Analysis A2
Analysis A1
Analysis B2
Analysis B1
17. Slide 17PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Data analysis methods
1. Classical Analysis of Variance (ANOVA)
Variations associated with different sources (analysis and
sampling) can be isolated and estimated
18. Slide 18PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Data analysis methods (continued)
2. Robust Analysis of Variance
Particularly appropriate for providing estimated of variances, in
cases where the validity of classical ANOVA is doubtful
It is insensitive to distributional assumptions (such as normality)
It can tolerate a certain amount of unusual observations (outliers)
It uses robust estimates of the mean and standard deviation calculated by an
iterative process (Huber’s method). Extreme values that exceed a certain
distance from the sample mean are downweighted or brought in.
19. Slide 19PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Data analysis methods (continued)
3. Range Statistics
The variance of sampling is calculated indirectly as the difference
of the variances of measurement and analysis.
2
analysis2
tmeasuremen
2
sampling
2
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128.1
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tmeasuremen
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Sampling
target
Sample B
Sample A
Analysis A2
Analysis A1
Analysis B2
Analysis B1
20. Slide 20PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Results
•Robust ANOVA leads to
statistically significantly
different results (F-test)
compared to the other two
methodologies.
•Robust ANOVA, which is
not influenced by less than
10% outliers, is considered
as the method providing
the most reliable estimates
21. Slide 21PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Discussion
Different results is an indication
that the assumptions of classical
ANOVA and range statistics are not
justified
Classical ANOVA and range
statistics are strongly affected by
the presence of outlying values (9
out of 104 datasets - 8.7 %).
22. Slide 22PhD Thesis – D. Theodorou
Measurement uncertainty arising from sampling
Discussion (continued)
The measurement uncertainty of manual sampling of fuels is
dominated by the analytical variance (accounts for the 71 % of
the measurement uncertainty)
This leaves “room” for an effective reduction e.g. by making
more measurements and calculating their average, instead of
making a single measurement.
Then the standard deviation of the mean gets smaller as the
number of data increases leading to smaller random error
uncertainty contributions.
2
analysiss -20 % Expanded uncertainty
of measurement
23. Slide 23PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Test method studied
Gross Heat of Combustion (GHC) (or Higher Calorific Value)
determination of a diesel fuel using a bomb calorimeter and
following the standard method ASTM D240
Measurement principle
Heat of combustion is determined in this test
method by burning a weighed sample in
an oxygen bomb calorimeter under
controlled conditions. The heat of
combustion is computed from temperature
observations before, during and after
combustion, with proper allowance for
thermochemical and heat transfer
corrections.
24. Slide 24PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Equipment used – Parr Instruments
Parr 6200 calorimeter
Parr 1108 oxygen bomb
Parr 6510 water handing system
Reference material
Benzoic acid traceable to NIST SRM 39j
25. Slide 25PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Measurement system modeling
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26. Slide 26PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Uncertainty estimation methods
GUM uncertainty framework
Assumed normal distribution
Assumed t-Student distribution (use of effective degrees of freedom)
Monte Carlo Method (MCM)
Fixed number of trials
Adaptive MCM
GUM with Bayesian statistics
Empirical method using interlaboratory study
(Proficiency Testing Scheme) data
27. Slide 27PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
GUM uncertainty framework vs Monte Carlo Method (MCM)
Formulation
- Definition of the output quantity (measurand)
- Determination of the input quantities (sources of
uncertainty)
- Development of a model relating the output quantity
with the input quantities
- Assignment of PDFs to the input quantities on the
basis of available knowledge
Propagation
- Propagation of the PDFs of the input quantities through
the model to obtain the PDF for the output quantity
Summarizing
- Use of the PDF of the output quantity to obtain the
expectation (measurement result) of the output quantity
- Use of the PDF of the output quantity to obtain the
standard uncertainty associated with expectation
- Use of the PDF of the output quantity to obtain a
coverage interval containing the output quantity with a
specified probability
PDF: Probability Density Function
No difference
28. Slide 28PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
GUM uncertainty framework vs Monte Carlo Method (MCM)
Formulation
- Definition of the output quantity (measurand)
- Determination of the input quantities (sources of
uncertainty)
- Development of a model relating the output quantity
with the input quantities
- Assignment of PDFs to the input quantities on the
basis of available knowledge
Propagation
- Propagation of the PDFs of the input quantities through
the model to obtain the PDF for the output quantity
Summarizing
- Use of the PDF of the output quantity to obtain the
expectation (measurement result) of the output quantity
- Use of the PDF of the output quantity to obtain the
standard uncertainty associated with expectation
- Use of the PDF of the output quantity to obtain a
coverage interval containing the output quantity with a
specified probability
PDF: Probability Density Function
x1, u(x1)
Y = f (X1,X2,X3) y, u(y)x2, u(x2)
x3, u(x3)
Assumed PDF for Y
GUM
MCM
PDF for X1
PDF for X2
PDF for X3
Y = f (X1,X2,X3)
PDF for Y
Propagation of uncertainties
Propagation of distributions
29. Slide 29PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
GUM uncertainty framework vs Monte Carlo Method (MCM)
Formulation
- Definition of the output quantity (measurand)
- Determination of the input quantities (sources of
uncertainty)
- Development of a model relating the output quantity
with the input quantities
- Assignment of PDFs to the input quantities on the
basis of available knowledge
Propagation
- Propagation of the PDFs of the input quantities through
the model to obtain the PDF for the output quantity
Summarizing
- Use of the PDF of the output quantity to obtain the
expectation (measurement result) of the output quantity
- Use of the PDF of the output quantity to obtain the
standard uncertainty associated with expectation
- Use of the PDF of the output quantity to obtain a
coverage interval containing the output quantity with a
specified probability
PDF: Probability Density Function
GUM
MCM
U = k u(y)
30. Slide 30PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
GUM uncertainty framework – Uncertainty budget
31. Slide 31PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
GUM uncertainty framework – Uncertainty contributions
32. Slide 32PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
GUM uncertainty framework – Expanded uncertainty /
Coverage interval estimation
Assumed probability distribution
Standard uncertainty u(Qg) =141.7 J g-1 (33.84 cal g-1)
Normal (Gaussian)
distribution
t- distribution
Expanded uncertainty U(Qg)=k . u(Qg)
k=1.96
k=2.08
22 effective degrees
of freedom
U(Qg)=277.7 J g-1 (66.3 cal g-1)
U(Qg)=294.6 J g-1 (70.4 cal g-1)
Welch–Satterthwaite formula
33. Slide 33PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Monte Carlo Method (MCM)– Development
The algorithm of MCM was developed in MATLAB®
1
2
…
n
Number of trials
o Fixed (106)
o Increasing number of
trials until the results have
stabilized in a statistical
sense (Adaptive MCM)
34. Slide 34PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Monte Carlo Method (MCM)– MATLAB code flow diagram
Establishment of the process parameters and the
default values of the control variables
Creation of M size row vectors for each of the input
variables
Evaluation of the model. M size file vector
Calculation of the average, standard deviation and
symmetrical interval of the M value sequence
Shortest interval?
Calculation of the shortest coverage interval of the M
value sequence
Value matrices and parameter vectors are formed
First sequence?
Add row to value matrices and parameter vectors
Calculation of the standard deviation of the
parameters
Calculation of the total standard deviation
Calculation of the numerical tolerance related to the
standard deviation
Stabilization?
Calculation of the average and the symmetrical
coverage interval of all the values
Shortest interval?
Calculation of the shortest coverage interval of all the
values
Show results
YES: Interval=1
YES: h=1
YES: Interval=1
YES: comp=1
NO
NO
NO
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35. Slide 35PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Monte Carlo Method (MCM)– MATLAB code Flow diagram
36. Slide 36PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Monte Carlo Method (MCM)–– Expanded uncertainty /
Coverage interval estimation
1 using a PC equipped with Intel® Core™ i3 M330, 2.13GHz, 4GB RAM
37. Slide 37PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
MCM results vs GUM results (95% coverage intervals)
12% underestimation
7% underestimation
38. Slide 38PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
GUM with Bayesian treatment of Type A uncertainties
)(
3
1
)( iiBayes xs
m
m
xu
Standard uncertainty, u(Qg) = 160.7 Jg-1 (38 cal g-1)
95% coverage interval
[44.88 – 45.51] MJ kg-1
or [10719 – 10870] cal g-1
Comparable
to MCM results !!!
39. Slide 39PhD Thesis – D. Theodorou
Measurement uncertainty estimation of an
analytical procedure
Uncertainty evaluated from proficiency testing data
zl
sl
s z
i
i
z
i
i
Ri
pooled
R
1
1
2)(
)1(
• The PTS provider is accredited according to
ISO/IEC 17043
• Most of the participants used the standard
method ASTM D240 for the measurement
li :number of participating laboratories in round i,
z: number of rounds
95% expanded uncertainty 0.30 MJ kg-1 (71 cal g-1)
pooled
Rg sQU 96.1)(
-6,3 % compared to MCM
40. Slide 40PhD Thesis – D. Theodorou
Estimation of the standard uncertainty of a
calibration curve
Calibration often
comprises an important
uncertainty component
of the uncertainty of the
whole analytical
procedure
The slope and the intercept of a linear calibration model
are only estimates based on a finite number of
measurements
Therefore their values are associated with uncertainties
41. Slide 41PhD Thesis – D. Theodorou
Estimation of the standard uncertainty of a
calibration curve
2 stage - measurement model
xbbY 10
1
00
pred
b
by
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calibration data
(pairs of xi yi)
0y
correlated
42. Slide 42PhD Thesis – D. Theodorou
Estimation of the standard uncertainty of a
calibration curve
The standard uncertainty of a calibration curve used for
the determination of sulfur mass concentration in fuels
has been estimated using 4 methodologies:
GUM uncertainty framework
Kragten numerical method
Monte Carlo method (MCM)
Approximate equation calculating the standard error of
prediction
n
i
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yy
Nnb
SE
xs
1
22
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2
0
1
regression
pred
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by
x
43. Slide 43PhD Thesis – D. Theodorou
Estimation of the standard uncertainty of a
calibration curve
Results
Mean value (ng μL-1)
Standard uncertainty
(ng μL-1)
GUM (correlation included) 8.000 0.175
Kragten method (correlation included) 8.000 0.172
MCM (correlation included) 8.003 0.175
Standard error of prediction equation
(including response uncertainty) 8.000 0.175
Standard error of prediction equation
(no response uncertainty included) 8.000 0.137
GUM (no correlation included) 8.000 0.283
Kragten method (no correlation
included) 8.000 0.279
MCM (no correlation included) 8.005 0.284
n
i
i xxb
yy
Nnb
SE
xs
1
22
1
2
0
1
regression
pred
11
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2
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2
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n
i
i xxb
yy
nb
SE
xs
1
22
1
2
0
1
regression
pred
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Overestimation of uncertainty by 62%
44. Slide 44PhD Thesis – D. Theodorou
Estimation of the standard uncertainty of a
calibration curve
Bivariate (or joint) Gaussian distribution N(E,V)
characterized by the expectation and the covariance (or
uncertainty) matrices, E and V
1b
b
E o
)(),(
),()(
1
2
10
100
2
bubbu
bbubu
V
A coverage region can be determined
Two types:
•rectangle centered coverage region (separately
determined coverage intervals for b1 and b0).
•ellipse centered coverage region
specifies a region in
2-dimensional space
that contains E with
probability p
Treating calibration curve as a bivariate measurement model
45. Slide 45PhD Thesis – D. Theodorou
Estimation of the standard uncertainty of a
calibration curve
(η – E)T V-1 (η – E) = kp
2
2
11
00
1
1
2
10
100
2
1100
)(),(
),()(
pk
bn
bn
bubbu
bbubu
bnbn
Rectangular and elliptical coverage regions (p=0.95)
p=0.95
46. Slide 47PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
Certain approaches should be used to support reliable
decisions in conformity assessment of fuels (EN 228, EN 590)
It is necessary to take into account the
dispersion of the values that can be
attributed to the measurand.
47. Slide 48PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
The comparison of the result with the specified requirements should be based
on predefined decision rules, which are of key importance when the result is
close to the tolerance limit
Use of guard bands to determine acceptance or rejection zones taking into
account measurement variability
Guarded acceptance
Guarded rejection
(Relaxed acceptance)
No rule
48. Slide 49PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
Guard bands minimize the probability of incorrect decisions (risks)
Guarded acceptance decision rules for upper
and lower specification limits (TU, TL) and
maximum probability of false
acceptance (Type II error) when guard
bands of width w are used
Guarded rejection (relaxed acceptance)
decision rules for upper and lower
specification limits (TU, TL) and maximum
probability of false rejection (Type I
error) when guard bands of width w are
used
49. Slide 50PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
Approaches for defining guard bands
The between laboratory precision data approach (ISO 4259 approach)
The intermediate precision (or uncertainty estimate) approach
ISO 4259:2006
Petroleum products -- Determination and application of precision
data in relation to methods of test
Widely used in fuel market for resolution of disputes
50. Slide 51PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
The between laboratory precision data approach (ISO 4259 approach)
Sulphur content test method limits
Product Automotive diesel
Specification 10 mg/kg
Dispute Sulphur content off specification
Test method ISO 20846
Reproducibility value R = 0.112*x + 1.12
x = sample result
For x=10, R = 2.24
Upper limit of guard band = TU+0.59*R
=10+0.59*2.24
=11.3 mg/kg
The product can be considered as FAILING the specification when a
single test results falls above 11.3 mg/kg (for 95% confidence level)
51. Slide 52PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
The between laboratory precision data approach (ISO 4259 approach)
k
rRR
1
122
1
For multiple (k) test results
The expressions have been applied for all the parameters related to
automotive fuel quality referred in EN 590:2009 and EN 228:2008 and
the acceptance limits were calculated using the precision data of the
relevant test methods
52. Slide 53PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
The between laboratory precision data approach (ISO 4259)
unleaded petrol
(gasoline) EN228
automotive diesel
EN 590
53. Slide 54PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
The intermediate precision (or uncertainty estimate) approach
Sulphur content test method limits
Product Automotive diesel
Specification 10 mg/kg
Dispute Sulphur content off specification
Test method ISO 20846
Standard uncertainty value u = 0.31
Upper limit of guard band = TU+1.64*u
=10+1.64*0.31
=10.5 mg/kg
The product can be considered as FAILING the specification when a
single test results falls above 10.5 mg/kg (for 95% confidence level)
54. Slide 55PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
The intermediate precision (or uncertainty estimate) approach
2
analysis2
sampling
k
u
uu
For multiple (k) test results
55. Slide 56PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
Automotive diesel fuel samples were taken from 769 petroleum retail
stations and their sulfur mass content was determined in order to assess
their compliance with the EU regulatory limit of 10 mg kg-1
56. Slide 57PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
The effect of different approaches for defining guard bands, different levels
of confidence or different number of replicate measurements is
investigated
ISO 4259 approach
57. Slide 58PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
Intermediate precision approach
58. Slide 59PhD Thesis – D. Theodorou
Measurement uncertainty and precision data in
conformity assessment
General remarks
The larger the width of the guard band used, the larger the proportion of
samples that will be judged incorrectly
The differences in the calculations of the two approaches reflect a possible
number of samples judged incorrectly when using the ISO 4259 approach
(uncertainty estimates represent more precisely the dispersion of the values of
the measurand)
Minimizing the guard band width by reducing the measurement uncertainty
(more replicates, more accurate measurement method) leads to fewer cases
of false acceptance or false rejection decisions, reducing as well the
costs associated with these decisions.
At the same time the cost of analysis becomes higher, there is a need that
these two costs are balanced against each other in order to find an optimum
(target) measurement uncertainty
59. Slide 60PhD Thesis – D. Theodorou
Conclusions
SAMPLING
MEASUREMENT
PROCEDURE
REPORTING
RESULTS AND
ASSESSING
CONFORMITY
Statistical and numerical methods have been developed
and/or applied concerning the estimation and use of the
measurement uncertainty in all parts of the measurement
process.
60. Slide 61PhD Thesis – D. Theodorou
Conclusions
SAMPLING
MEASUREMENT
PROCEDURE
REPORTING
RESULTS AND
ASSESSING
CONFORMITY
Manual sampling from petroleum retail stations for sulphur determination
Three alternative empirical statistical approaches
Expanded uncertainty of sampling estimated in the range of 0.34 – 0.40
mg kg-1.
The estimation of robust ANOVA (0.40 mg kg-1) is considered more
reliable, because of the presence of outliers
61. Slide 62PhD Thesis – D. Theodorou
Conclusions
SAMPLING
MEASUREMENT
PROCEDURE
REPORTING
RESULTS AND
ASSESSING
CONFORMITY
Gross Heat of Combustion of diesel fuel
Two alternative modelling approaches (GUM and Monte Carlo Method)
GUM approaches (Gaussian or t-distribution) underestimate
measurement uncertainty
Overall Monte Carlo Method is a more reliable tool (subject to fewer
assumptions) (0.32 MJ kg-1)
Bayesian treatment of Type A uncertainties “corrects” GUM estimates
62. Slide 63PhD Thesis – D. Theodorou
Conclusions
SAMPLING
MEASUREMENT
PROCEDURE
REPORTING
RESULTS AND
ASSESSING
CONFORMITY
Calibration curve construction (Sulphur content determination)
Four alternative approaches (GUM, Monte Carlo Method, Kragten,
standard error equation)
All approaches agree well (std uncertainty 0.172 – 0.175 ng μL-1)
Importance of correlation – correct use of standard error equation
63. Slide 64PhD Thesis – D. Theodorou
Conclusions
SAMPLING
MEASUREMENT
PROCEDURE
REPORTING
RESULTS AND
ASSESSING
CONFORMITY
Conformity assessment of automotive fuel products (EN 590, EN 228)
Acceptance limits for guarded acceptance and guarded rejection for 95%
and 99% confidence levels
Significant differences in the resulting number of non-conforming results
when using different approaches for defining guard bands, different
levels of confidence or different number of replicate measurements
64. Slide 65PhD Thesis – D. Theodorou
Applications
The program codes developed in MATLAB in order to
apply the Monte Carlo method (adaptive and fixed trials)
may be used in any type of measurement
Decision Support System for the Evaluation of Conformity
of Fuel Products (key features defined)
65. Slide 66PhD Thesis – D. Theodorou
Future Work
Bayesian uncertainty analysis – Development of numerical
techniques
Conformity assessment – Take into account the variability
of both the measuring system and the process (production
system)
Sampling - Development of methods for the estimation
and the inclusion of sampling bias
66. Slide 67PhD Thesis – D. Theodorou
List of publications - Conferences
PUBLICATIONS
1. D. Theodorou, Y. Zannikou, G. Anastopoulos, F. Zannikos. Coverage interval estimation of the
measurement of Gross Heat of Combustion of fuel by bomb calorimetry: Comparison of ISO GUM and
adaptive Monte Carlo method. Thermochimica Acta (2011) 526: 122– 129
2. D. Theodorou, Y. Zannikou, F. Zannikos. Estimation of the standard uncertainty of a calibration curve:
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CONFERENCES
5th National Congress on Metrology "Metrologia 2014”
EuroAnalysis 2013 - XVII European Conference on Analytical Chemistry
4th National Congress on Metrology "Metrologia 2012”
67. Slide 68PhD Thesis – D. Theodorou
Acknowledgments
Advisory Committee
F. Zannikos –Professor – School of Chemical Engineering, NTUA
(Supervisor)
K. Tzia - Professor – School of Chemical Engineering, NTUA
D. Karonis – Associate Professor - School of Chemical Engineering,
NTUA
Fuels and Lubricants Technology Laboratory
Staff
Partners
Graduate / Post graduate students
68. Slide 69PhD Thesis – D. Theodorou
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