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Identify Biomarkers for Susceptibility to Both Type 1 Diabetes and Mental Disorders

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Recent studies show that patients with diabetes have a much higher likelihood of depression than the general population, and young people with type 1 diabetes (T1D) had 11 times the suicide rate. Our goal is to identify genetic signatures in white blood cells that distinguish non-progressor T1D patients and T1D patients that do progress to psychiatric illness.

Published in: Health & Medicine
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Identify Biomarkers for Susceptibility to Both Type 1 Diabetes and Mental Disorders

  1. 1. Agata Jurczyk, Ph.D.
  2. 2. • The way beta cells store and release insulin in response to stimuli mimics the way neurons store and release neurotransmitters Brain neurotransmitter release   Neuron Pancreas Islet of Langerhan Beta cell Insulin release ≈
  3. 3. • Similar genes and proteins expression DISC1 GAD1 GAD2 IA2 Associate with risk to type 1 diabetes and mental disorders
  4. 4. depression type 1 diabetes bipolar disorders schizophrenia
  5. 5. Blood Gene Signature Type 1 diabetes + mental illness Type 1 diabetes vs
  6. 6. Experimental Approach Biorepository of blood samples Healthy Controls Type 1 diabetes Type 1 diabetes with schizophrenia Type 1 diabetes with bipolar disorder Type 1 diabetes with depression Blood RNA DNA Healthy Gene Signature Type 1 diabetics Type 1 diabetics with mental illness
  7. 7. Identify Novel Molecules and/or Pathways to Improve Therapies to Alleviate Suffering Caused by Both illnesses Outcome
  8. 8. Type 1 diabetes and mental disorders alone are very devastating diseases, now imagine what patients have to go through when faced with both? Your support will fund a project that is trying to help these people to take preventive measures or to find better treatment
  9. 9. Type 1 diabetes and mental disorders alone are very devastating diseases, now imagine what patients have to go through when faced with both? Your support will fund a project that is trying to help these people to take preventive measures or to find better treatment

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