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Corporative presentation deretil_2021 de Deretil, S.A.

Deretil with more than 50 years of experience in performing technological solutions aimed to improve the quality of life, is one of the leading companies worldwide in the fields of research, development, manufacturing and sales of raw materials for the production of semisynthetic antibiotics, such as penicillins and cephalosporins.

Deretil has over 50 years of experience in the pharmaceutical industry and is a global leader in the production of semisynthetic antibiotics. The most important antibiotics consumed globally and world’s best-known brands are made with the products manufactured by Deretil.

External acknowledgements obtained by the company include certification of our Comprehensive Quality, Health and Safety Management System in accordance with the following standards: ISO 9001 / ISO 14001.

Our values and philosophy:
Health, Safety and Environment
Product life cycle stewardship
Ongoing training
ISO 14001 Certification
Responsible Care Commitment

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Corporative presentation deretil_2021 de Deretil, S.A.

  1. 1. www.deretil.com January 2021 CORPORATE PRESENTATION
  2. 2. From north to south the Mediterranean coastline joins Barcelona and Villaricos, where Deretil has its manufacturing site. LOCATIONS January 2021
  3. 3. OUTSTANDING SITUATION  The strategic layout of the factory, the financial and commercial office provide us the right prospect of our present and a great overview of the future.  Manufacturing site: Villaricos, Cuevas del Almanzora, Almería, Spain January 2021
  4. 4. 2021 Villaricos HISTORICAL FACTS Villaricos 1978 1961 1981 1996 1975 1992 1998 Creation of Derivados del Etilo, S.A. Active in Bromine till 1983 Start in side chains manufacturing (PGCH) Start-up of Phenylglycine Base (PG Base) Start of Parahidroxy Phenylglycine Enzymatic production Line (PHPG) Deretil was acquired by DSM. NV (Dutch multinational Company) New Parahidroxy Phenylglycine plant (PHPG) 1998/9 New waste-water treatment plant
  5. 5. HISTORICAL FACTS 2003 2005 2002 2004 2006 New Products: Allantoin, PH Glycol Ester Purimox® plant (enzymatic amoxicillin) New expansion of PHPG plant Start of Strategic Plan 2005-2007 Expansion projects and Customer Service 2007 2008 2009 FDA approval in Good Manufacturing Practices (cGMP) Management Buy-out Introduction of New Products, Custom Manufacturing, etc)
  6. 6. HISTORICAL FACTS 2015 2011-13 2016 Standard FDA Inspection, Management Priorities and Customer Service Consolidation of the Quality & SHE Management System and the business Standard FDA Inspection 2017-18 Implementation of SAP ERP System 2019 2020 Recertifications w.r.t. the Integrated Quality, Safety, Health & Environment Management System:  ISO 9001:2015  ISO 14001:2015 Recertifications in cGMP:  FDA/AEMPS Amoxicillin  ISO 22716:2008 Cosmetics Adaptation to the latest Versions of:  ISO 9001:2015  ISO 14001:2015 Start of SAP ERP System Project
  7. 7. Principal Industrial advantages Expertises in handling large volumes (solid/liquid) Dedicated Production plants Enzymatic technology, fermentation Principles of Manufacturing Excellence Integrated Q+SHE System Biological waste-water treatment plant (sea water) Side chains Manufactured By Deretil Side chains Manufactured By Deretil Use in the manufacture of Betalactamic antibiotics Danfenil® = D(-)Alpha Phenylglycine Dane Salt, Ethyl Potassium Ampicillin Cefaclor Cefalexine PGA = D(-)Phenylglycine Amide Cefalexine PHPG = D(-)Alpha Parahydroxy Phenylglycine Amoxicillin Cefadroxil HPGM = D(-)Alpha Parahydroxy Phenylglycine, Methyl Esther Amoxicillin Cefadroxil Danoxi® = D(-)Alpha Parahydroxy Phenylglycine, Methyl Potassium Amoxicillin Cefadroxil PRODUCTS AND APPLICATIONS January 2021
  8. 8. PRODUCTION Production plants The factory in Villaricos comprises six industrial plants, where a like number of products are manufactured:  Parahidroxy Phenylglycine Dane Salt Danoxi® Commercialized since 1990  D (-) Phenylglycine Dane Salt - Danfenil® Marketed since 1990  D (-) Parahidroxy Phenylglycine Two industrial facilities: Manufactured since 1992 and expanded with a second plant in 1998  Purimox® Amoxicillin, an antibiotic produced since 2002  Multi–purpose plant Allantoin Phenylglycine Amide January 2021
  9. 9. TOP PRIORITIES Ongoing training Safety, Health and the Environment Policy encourages our ongoing training activities. Deretil’s efforts in this area have led to maintain workplaces almost injury-free, which have been recognised by the Spanish Independent Commission for Safety and Hygiene in Chemical Industries.  Registered in cGMP by the FDA for API: Purimox®  Certificate of cGMP Compliance by the Spanish Agency of Health  ISO 9001:2015  ISO 14001:2015  ISO 22716:2008 (Cosmetic cGMP) January 2021
  10. 10. ORGANIZATION Management Team Knowing how to coach means knowing how to entrust. We believe and bet on the human value of a great team, who keep together and are prepared to continue replying to the society’s needs. GENERAL MANAGER Mr. Antonio Arroyo FINANCE & CONTROL Mr. Ferran Barral MANUFACTURING Mr. Gracian Gutiérrez PRODUCTION Almería COMMERCIAL Mr. Antonio Arroyo January 2021
  11. 11. ORGANIZATIONAL CHART Barcelona Headquarters General Manager Antonio Arroyo Finance & Control Ferran Barral Commercial Antonio Arroyo Sales Cristian Izquierdo Purchasing & Logistics Gerardo Frontera Treasurership Sandra Izquierdo Administration Deputy Manager Mireia Martin Controller Mar Reis January 2021
  12. 12. ORGANIZATIONAL CHART Almeria Site SITE DIRECTOR G. Gutierrez QUALITY CONTROL A. Sánchez-Fresneda QUALITY ASSURANCE M. C. Navarro PERSONNEL & GENERAL AFFAIRS R. López PURCHASING C. López PRODUCTION J.A. Torres ENGINEERING E. Cruz PRODUCTION & FACILITIES Plant Managers & Shift supervisors A-4000 A-9000 A-10000 A-14000 A-15000 PURIMOX ® SERVICES: Legal, Medical,+ Administration, Vigilance, etc. LOGISTICS B. Gonzalez A-6000 A-8000 SAFETY, HEALTH & ENVIRONMENT F.J. Martínez DERETIL VITATECH R&D M. Santiandreu January 2021 MAINTENANCE A. Alonso
  13. 13. PEOPLE AND TECHNOLOGY TOGETHER WE MAKE DERETIL INJURY-FREE  Motivation and quality of our staff Fundamental for our goals achievement.  Essential Direct engagement of our employees in the process of optimizing operations and the way of learning from each other.  Staff evolution 2020: - Barcelona ………. 16 employees - Almeria …………. 182 employees TOTAL ………….. 198 employees January 2021
  14. 14. PEOPLE AND TECHNOLOGY  DERETIL, S.A.U. operates 24 hours a day, 7 days a week in three shifts.  The shift breakdown is: Shift 1 = 6.00 am through 2.00 pm Shift 2 = 2.00 pm through 10:00 pm Shift 3 = 10:00 pm through 6:00 am January 2021
  15. 15. SITE LAND  PROPERTY – TOTAL ……. 77 hec. - Total industrial soil ……… 36 hec. - Total rustic land …………. 33 hec. - Other applications ………. 8 hec. January 2021
  16. 16. Manufacturing Installations  The factory is a self-sufficient site provided with all necessary facilities and services: Electricity Cogeneration Plant Steam Water Sea water N2 production Air Brine WWTP Warehouses January 2021
  17. 17. LEGAL NAME AND ADDRESSES January 2021 Office: Deretil, S.A.U. Calle La Llacuna, 161, 2º 08018 Barcelona (Spain) Tel. +34 93 467 71 17 Fax +34 93 467 71 31 Factory: Deretil, S.A.U. Villaricos, s/nº 04616 Cuevas del Almanzora (Almeria, Spain) Tel. +34 950 618 000 Fax +34 950 467 401 www.deretil.com
  18. 18. www.deretil.com January 2021 SIDE CHAINS

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Deretil with more than 50 years of experience in performing technological solutions aimed to improve the quality of life, is one of the leading companies worldwide in the fields of research, development, manufacturing and sales of raw materials for the production of semisynthetic antibiotics, such as penicillins and cephalosporins. Deretil has over 50 years of experience in the pharmaceutical industry and is a global leader in the production of semisynthetic antibiotics. The most important antibiotics consumed globally and world’s best-known brands are made with the products manufactured by Deretil. External acknowledgements obtained by the company include certification of our Comprehensive Quality, Health and Safety Management System in accordance with the following standards: ISO 9001 / ISO 14001. Our values and philosophy: Health, Safety and Environment Product life cycle stewardship Ongoing training ISO 14001 Certification Responsible Care Commitment

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