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Ultrasonic Histology                              Debdoot SheetSchool of Medical Sc. and Tech., Indian Institute of Techno...
Motivation•    Atherosclerosis       – Plaque builds up in arteries       – Forms anywhere in the vascular         system•...
How do I    diagnose tissue   pathology in-vivo?                                                  Computed Tomography Radi...
Think tanksUltrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012)   4
Histology, practice of                                                                  Power                             ...
Power             350nm                     750nm                     White light source             Stained tissue sectio...
Ultrasonic interaction with tissues                r2                                                     r3              ...
Statistical physics of ultrasonic imaging                              P(r)                                         P(r)  ...
Here arrives our   Computational Imaging   Knight in shining armor   Ultrasonic HistologyUltrasonic Histology - Debdoot Sh...
Ultrasound RF data         Ultrasound RF data               Tissue labels                                                 ...
Ultrasonic Histology of  Atherosclerotic Plaques• Characterization based on ultrasonic statistical physics.• Superior mach...
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Ultrasonic Histology

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Ultrasonic Histology

  1. 1. Ultrasonic Histology Debdoot SheetSchool of Medical Sc. and Tech., Indian Institute of Technology Kharagpur, India andComputer Aided Medical Procedures, Technische Universität München, Germany (Indo-German Grand Science Slam, New Delhi, 27 Oct. 2012)
  2. 2. Motivation• Atherosclerosis – Plaque builds up in arteries – Forms anywhere in the vascular system• Cardiovascular diseases (CVD)• Accounted for 34.2% (829 072) of all 2 425 900 deaths in 2006 (USA)• 1 of every 2.9 deaths (USA)• There is a multi-billion dollar market – More than 1,000,000 angioplasties are performed only in the U.S. (CNN/Health, August 13th 2008). Source: NIH – National Heart, Lung, and Blood Institute Ultrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 2
  3. 3. How do I diagnose tissue pathology in-vivo? Computed Tomography Radiation exposure Magnetic Resonance Imaging ~ 10 hrs imaging time Intravasular Ultrasonography (IVUS) May be!Ultrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 3
  4. 4. Think tanksUltrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 4
  5. 5. Histology, practice of Power 350nm 750nm White light source Stained tissue section Calcified Fibrotic Power 350nm 750nm Tissue specific spectrumUltrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 5
  6. 6. Power 350nm 750nm White light source Stained tissue section Computational Histology Platform Calcified Fibrotic Power 350nm 750nm Tissue specific spectrum Computational Mapping of TissuesUltrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 6
  7. 7. Ultrasonic interaction with tissues r2 r3 Ω1 r2 r1 r1 P(r) Ω2 m=0.5 r Ω1 Ω2 Ω3 P(r) m=1.0P. M. Shankar, “A general statistical model for ultrasonicbackscattering from tissues”, IEEE Trans. Ultrasonics, Ferroelectrics,Freq. Control., vol. 47, no. 3, pp. 727-736, May 2000. r Ultrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 7
  8. 8. Statistical physics of ultrasonic imaging P(r) P(r) Lipidic Calcified r r V. Dumane and P. M. Shankar, “Use of frequency diversity and Nakagami statistics in ultrasonic tissue characterization”, IEEE Trans. Ultrasonics, Ferroelectrics, Freq. Control, vol. 48, no. 4, pp. 1139-1146, Jul. 2001 F. Destrempes, J. Meunier, M. . F. Giroux, G. P(r) Fibrotic Soulez, G. Cloutier, “Segmentation in ultrasonic b-mode images of healthy carotid arteries using mixture of Nakagami distributions and stochastic optimization”, IEEE Trans. Med. Imaging, vol. 28, no. 2, pp. r 215-229, Feb. 2009.Ultrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 8
  9. 9. Here arrives our Computational Imaging Knight in shining armor Ultrasonic HistologyUltrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 9
  10. 10. Ultrasound RF data Ultrasound RF data Tissue labels Compute ultrasonic statistical physics primal sketch (i)Nakagami coefficients (Ω,m) for speckle statistics Compute ultrasonic statistical (ii)Ultrasonic signal confidence physics primal sketch (i)Nakagami coefficients (Ω,m) for speckle statistics Predict tissue probabilities (ii)Ultrasonic signal using learnt Random Forest confidence Machine learning of tissue specific ultrasonic statistical physics primal sketch using Random Forest Characterized tissuesUltrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 10
  11. 11. Ultrasonic Histology of Atherosclerotic Plaques• Characterization based on ultrasonic statistical physics.• Superior machine learning algorithm.• Reliability measure for estimation of tissues. Calcified Lipidic Fibrotic Probability ofofNecrotic Probability ofCalcified Probability Fibrotic Lipidic Necrotic tissues tissues Ultrasonic Histology - Debdoot Sheet (Indo-German Grand Science Slam, New Delhi, 2012) 11

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