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How to use "Interactive comparison of false discovery rates and local false discovery rates" (Bickel, 2019)

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How to use "Interactive comparison of false discovery rates and local false discovery rates" (Bickel, 2019)

  1. 1. How to use "Interactive comparison of false discovery rates and local false discovery rates" (Bickel, 2019) David R. Bickel University of Ottawa June 23, 2020 http://bit.ly/2t9hX7DLink to the software:
  2. 2. Instructions 1. Install Mathematica or the free Wolfram CDF Player • Wolfram CDF Player: http://bit.ly/2vAF9w4 2. Open the "*.cdf" files from http://bit.ly/2t9hX7D 3. Interpret what you see according to the next slides 4. Play with the sliding controls to explore how the false discovery rate (FDR) differs from the local FDR 5. Answer Exercise CFDR3 on p. 80 of this book: • https://davidbickel.com/genomics/
  3. 3. FDR = mean(local FDR) Bickel (2019) "Interactive comparison of false discovery rates and local false discovery rates" http://bit.ly/2t9hX7D mean local FDR highest local FDR of the discoveries local FDRs of the discoveries# discoveries
  4. 4. FDR = mean(local FDR) (The abbreviations are defined in the previous slide.) Simple explanation of the concepts: Chapter 6 of https://davidbickel.com/genomics/
  5. 5. FDR = mean(local FDR)
  6. 6. FDR = mean(local FDR)
  7. 7. local FDRs of the discoveries highest local FDR of the discoveries The average of the 10 local FDRs is 0.2, but only 6 of them are less than 0.2.
  8. 8. (The abbreviations are defined in the previous slide.) Simple explanation: Chapter 6 of https:// davidbickel.com/genomics/

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