False Claims on Maqui Berry’sORAC Value• Maqui berry’s ORAC score: Several companies have claimed that the is significantly higher than açai’s.• Turns out the claim is false! The lab did not perform the test.• Lab responded:• ―We tried to reach ―company‖… to remove the false information from their website and materials…this kind of misinformation is frustrating.‖• ―Spoke to company. They will remove it.‖
Published Açai Researchin PubMed1994-2005• Up to 2003: 0 citations• 2004: 2 citations• 2005: 4 citations• 2006: 7 citations• 2007: 9 citations• 2011: 79 citations
2006-2010: Publications on AçaiResearch and MonaVie Stream into theScientific Literature• 2006: Schauss AG, et al. Federation of American dSocieties in Experimental Biology Journal 20: A145.• 2006: Schauss AG, et al. Journal of Agricultural and Food Chemistry 54: 8598-8603.• 2006: Schauss AG, et al. Journal of Agricultural and Food Chemistry 54: 8604-8610.• 2006: Schauss AG. Acai (Euterpe oleracea): An Extraordinary Antioxidant-Rich Palm Fruit.• 2007: Schauss AG, et al. Proceedings of the Second International Symposium on Human Health Effects of Fruits and Vegetables, Houston, Texas, pp. 39-40.• 2007: Schauss AG. Acai (Euterpe oleracea): An Extraordinary Antioxidant-Rich Palm Fruit. First foreign translation of English edition.• 2008: Jensen GS, et al. Journal of Agricultural and Food Chemistry 56: 8326-8333.• 2008: Honzel D, et al. Journal of Agricultural and Food Chemistry 56: 8319-8325.• 2008: Schauss AG. Symposium on Flavor and Health Effects of Small Fruits, Cornucopia, AGFD 95.• 2008: Schauss AG. Acai (Euterpe oleracea): An Extraordinary Antioxidant-Rich Palm Fruit. Second Edition Second foreign translation of English edition.• 2009: Schauss AG, et al. Proceedings of the Second International Symposium on Human Health Effects of Fruits & Vegetables. Acta Horticulturae 841: 97-100.• 2009: Jensen GS, et al. Alternative Therapies in Health and Medicine, 15: S90-S91.• 2010: Schauss AG. Bioactive Foods in Promoting Health: Fruits and Vegetables. Academic Press: Oxford, pp. 479-490.• 2010: Schauss AG, et al. Flavor and Health Benefits of Small Fruit. American Chemical Society Symposium Series: Oxford University Press, pp. 213- 223.
A Year of Discoveries on Açai& MonaVie 2010-2011• 2010: Sun X, et al. Experimental Gerontology 45: 243-251.• 2010: Kang J, et al. Food Chemistry 122: 610-617.• 2010: Schauss AG, et al. Toxicology 278: 39-45.• 2011: Chenghui X, et al. Atherosclerosis 216: 327-333.• 2011: Kang J, et al. Food Chemistry 128: 152-157.• 2011: Jensen GS, et al. Journal of Medicinal Food, Epub ahead of print.• 2011: Chenghui X, et al. Journal of Nutritional Biochemistry, under review.• 2011: Kang J, et al. Submitted for publication.• 2011: Poulose SM, et al. Submitted for publication.• 2011: Schauss AG. Submitted for publication.
2006-2011 Presentations atScientific Conferences• 2006: Schauss AG, et al. Federation of American Societies in Experimental Biology, San Francisco, CA. FASEB Journal 20: A145.• 2007: Schauss AG, et al. Proceedings of the Second International Symposium on Human Health Effects of Fruits and Vegetables, Houston, Texas.• 2008: Schauss AG. 236th American Chemical Society National Meeting, Division of Agricultural and Food Chemistry Symposium on Flavor and Health Effects of Small Fruits, Philadelphia, PA.• 2009: Schauss AG, et al. North American Research Conference on Complementary & Integrative Medicine, Minneapolis, MN.• 2010: Schauss AG, et al. Annual Meeting of the Society of Toxicology, Salt Lake City, UT.• 2010: Kang J, et al. Federation of American Societies in Experimental Biology, Anaheim, CA.• 2011: Xie C, et al. Federation of American Societies in Experimental Biology, Washington, DC.• 2011: Kang J, et al. Federation of American Societies in Experimental Biology, Washington, DC.
Discovery• Safety of MonaVie® juice studied.• 13 experimental in vitro and in vivo studies carried out over two years.• No evidence of genotoxicity or toxicity.• The no observable adverse effect level (NOAEL) for juice established.
Discovery• MonaVie® juice given to 48 to 84 year olds for 12 weeks. • Increased serum antioxidant status • Improved range of motion lower back and both knees • Improvement in activities of daily living
Discovery• Açai pulp contains potent anti-inflammatory and antioxidant compounds.• A flavonoid was isolated and shown to be a potent compound to help balance inflammatory mediators.
Brain Health and Aging• As we age, there is a decline in how efficiently our brain removes toxic proteins and other debris.• This is function is called autophagy, or simply brain housekeeping.• A decline in autophagy is linked to age-related memory loss, and mental decline.• As reported in August 2010, in an animal model, it was discovered that compounds in açai pulp activate autophagy and remove toxic proteins.Poulos, et al. Annual Meeting, Am Chem Soc., August, 2010, Boston. Shukitt-Hale, et al. Annual Meeting, Society Neuroscience, November, 2010.
Heart Health Myths1. It only affects the elderly.2. It doesn’t affect children.3. It doesn’t affect those who are fit and strong.4. If I had it, I’d feel sick.5. If my parents didn’t have it, I won’t get it.
DiscoveryAdding MonaVie juice to the diet in animal model*:• Significantly inhibiting formation of atherosclerotic lesions by nearly 60% (p<0.001)Proposed mechanisms of action:• Reduced lipid peroxidation• Increased antioxidant enzymes• Inhibition of pro-inflammatory cytokine production
New 3rd Edition of Açai Booktranslated into:• Chinese (Traditional)• French• German• Korean• Polish• Malaysian• Thai
Applied Research • Confirming the benefits of MonaVie® products as they are consumedEssential
MonaVie Active Antioxidant Capacity • Increase in serum antioxidants • Inhibition of lipid peroxidation
MonaVieRVL™ Study ResultsConclusions:•The study* demonstrateda statistically significantimprovement in bodymass index, weight andwaist circumference.* Small pilot study with 36 people for 28 days, inpersons 100% compliant with the RVL weightmanagement program.
E mv® Study Results• No increase in heart rate versus placebo• Perceived exertion lower with Emv• Reaction time improved with Emv• Participants felt more vigorous with Emv• Significant improvement of 20% in short- term memory with Emv
Testing the Efficacy of a New Energy Drink Robert Girandola, Ed.D. University of Southern California, Los Angeles, Ca. INTRODUCTION METHODOLOGY The popularity of energy drinks is undeniable. Over the past several years a number of energy A total of 25 volunteer subjects from the University of Southern California were used as subjects. After completion of signed informed consent forms (IRB drinks and energy shots have been introduced with incredible popularity. The present market approved), they were informed that the study was actually testing two different energy drinks, to determine which one was superior. Prior to reporting to for energy drinks in the USA is in the multi billion-dollar range. Research as to the efficacy of the laboratory, subjects were given two 9 oz clear plastic, generic bottles of the MonaVie (MV) OR Placebo (P: carbonated Arrowhead water into which energy drinks has focused on both cognitive abilities as well as performance variables. Several was mixed a red food color dye and half a package of the dietary sweetener, Splenda). The outside of the bottles was marked “A” (MV) or “B” recent studies have found that subjects had more alertness and performed better in physical (Placebo). Subjects were told to take both bottles home and to consume the contents on ONE of the bottles, one hour prior to reporting to the lab. tasks, following ingestion of an energy drink. However, others have not found similar Subjects were told not to consume and food or beverages after consuming the experimental fluid, prior to reporting to the laboratory. The subjects diet improvements. was not monitored but they were encouraged to consume the same diet on the two testing days. We endeavored to test subjects at the same times on the two testing days. Since caffeine is the major active ingredient in these energy drinks it is unclear whether theimprovement is related to this substance or other ingredients. In addition, since the caffeine load Upon reporting to the laboratory subjects were given a choice reaction/movement time test as a warm-up/practice. A Polar heart rate (HR) recording can be substantial, the safety of these energy drinks has been called into question. The strap was attached to the chest and then subjects were asked to walk on the treadmill. Prior to the walk, subjects were shown a chart displaying 8 random introduction of a new energy drink based upon fruit juices and less caffeine was the stimulus words and were told to memorize as many as they could. For the first 2 minutes speed was 3 mph and 0%grade. At the 3rd minute, grade was increased resulting in the current research study. to 10% and HR was recorded continuously. At the 9:30 minute subject was shown the Borg scale (Rating of Perceived Exertion [RPE] – 0-10) and asked to rate his/her level of intensity. Following the exercise, subjects were given the RT/MT test, with the average of 5 trials recorded. After the MonaVie has developed such an energy drink made up of 80% fruit juices. In addition the subjects toweled off and were seated, they were given a piece of paper and were told to write down as many of the 8 words they could remember.carbohydrate source was Palatinose, a slower digested and metabolized sugar. The 8.4 oz can Subjects were then administered the Profile of Mood States (POM) to identify the vigor score. This psychological test has been shown to be a reliablecontains 40 g of CHO (22 g sugar and 15 g Palatinose) 160 Calories. Included in the ingredients measure of vigor in both average people and athletes. At the conclusion of the POMS test, subjects were told to write down their subjective feelings after are: caffeine ( < 60 mg), D-ribose, ginseng, green tea and guarana. ingesting the fluid and after the laboratory exercises. PURPOSE Statistical Analysis: a paired, 2-tailed, students T-Test was used to compare the means for each measurement between trials (A: MV) and (B: Placebo). The present study was designed to determine if a new energy drink would improve Statistical significance was determined at p<0.05. exercise and cognitive functions in human subjects, when compared to a placebo. RESULTS: Means, SD, and T-Test Results for Each Measure Following Exercise & Cognitive Testing RESULTS The average age of the subjects was 20 yrs. Of the 25, 11 were females and 14 were males. Average BMI was 22.39 kg/m2 . Heart rates for the two drinks were 150.52 and 150.16 bpm, respectively, for both days. The HR was an indication that the exercise intensity was approximately 65-70% of max. The RPE for the MV drink was 3.90 vs. 4.16 for the placebo condition, a difference of 6.7%, but this was not statistically significant. Similarly, the RT/MT values were faster and the POMS vigor score higher for the MV condition, but neither achieved statistical significance. Interestingly, the only variable that was statistically significant was the memory score, 6.00 vs. 5.04 for the placebo condition. CONCLUSIONS We attempted to use both physical and psychological tests to determine if this new drink improved exercise or cognitive function, however, based on the data, we were unable to reach any real conclusions. With some of the safety concerns regarding current energy drinks on the market, especially with the large concentration of caffeine in a relatively small volume, the MV beverage might offer a safer and healthier alternative. Future research on this energy drink should focus on a somewhat longer time frame between ingestion and testing (2 hours) and a more intense and longer bout of exercise. Acknowledgements: The author would like to acknowledgeReferences: Van den Eynde R, van Baelen PC, Portzky M, Audenaert K. The effects of energy drinks on cognitive performance. Tijdschr Psychiatr. 2008:50 (5): 273-81. Alford C, Cox H, Wescott R. The effects of red bull energy drink on human performance and mood. Amino Acids. 2001;21(2): 139-50. Rahnama N, Gaeini AA, Kazemi F. The effectiveness of two energy drinks on selected indices of maximal cardiorespiratory fitness and blood lactate levels in male athletes. J Res Med Sci. 2010 May; 15(3): 127-32. Astorino TA, Matera AJ, Basinger J, Evans M, Schurman MonaVie for their support of this study.T, Marquez R. Effects of red bull energy drink on repeated sprint performance in women athletes. Amino Acids. 2011, Apr 3. Higgins JP, Tuttle TD, Higgins CL. Energy beverages: content and safety. Mayo Clin Proc. 2010 Nov;85(11): 1033-41. Duchan E, Patel ND, Feucht C. Energy drinks:a review of use and safety for athletes. Phys Sportsmed. 2010 Jun;38(2): 171-9. Ballard SL, Wellborn-Kim JJ, Clauson KA. Effects of commercial energy drink consumption on athletic performance and body composition. Phys Sportsmed. 2010 Apr;38(1): 107-17. Candow DG, KleisingerAK, Grenier S, Dorsch KD. Effect of sugar-free Red Bull energy drink on high-intensity run time-to-exhaustion in young adults. J Strength Cond Res. 2009 Jul;23(4): 1271-5. Ivy JL, Kammer L, Ding Z, Wang B, Bernard JR, Liao YH, Hwang Improved cycling time-trial performance afteringestion of a caffeine energy drink. Int J Sport Nutr Exerc Metab. 2009 Feb; 19(1):61-78.
Studies in Progress• MonaVie (M)mun — ® confirming immune support benefits• 2nd MonaVie RVL Clinical Study
MonaVie Products...Best in Class• MonaVie is a cutting edge nutrition company providing innovative, science- based products: • Functional juices of superior nutrient density and diversity • Healthier energy drinks • Scientifically supported weight management system
What Does the Future Hold?• Searching the world for new ingredients• Enhance current health benefits• Create new categories of benefit • Continuous innovation in product form, function, and taste