Phylogenetic Study of mdm2Yosok PunY
p53 and mdm2 interactions
Mdm2Negative regulator of p53 tumor suppressorgeneDiscovery from transformed mouse cell lineMdm2 over expression with R...
Mdm2Increased levels ofmdm2 found in:Soft tissue sarcomasOsteosarcomasBreast tumors
Cn3D
E3 ligase activityTargets both itself and p53for degradation byproteasomeInhibitor of MDM2-p53interactions is nutlinMDM...
JalView
Mdm2 [Homo sapiens] FASTA>gi|155183770|gb|ABT17086.1| Mdm2 [Homo sapiens]MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYT...
ClustalW2
HomoloGeneHomologs werediscovered in thesevertebrates:Chimpanzee, Rhesusmacaque, Dog,Cattle, House mouse,Brown rat, RedJun...
ReferencesHarris. Curtis C. et. al. Proceedings of the National Academy of Sciences.http://www.pnas.org/content/103/6/165...
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
Phylogenetic Study of Mdm2
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Phylogenetic Study of Mdm2

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A phylogenetic study og Mdm2 using tools like ClustalW2 and unrooted trees.

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Phylogenetic Study of Mdm2

  1. 1. Phylogenetic Study of mdm2Yosok PunY
  2. 2. p53 and mdm2 interactions
  3. 3. Mdm2Negative regulator of p53 tumor suppressorgeneDiscovery from transformed mouse cell lineMdm2 over expression with Ras oncogene ledto tumor formation in nude miceHuman homolog is sometimes called Hdm2
  4. 4. Mdm2Increased levels ofmdm2 found in:Soft tissue sarcomasOsteosarcomasBreast tumors
  5. 5. Cn3D
  6. 6. E3 ligase activityTargets both itself and p53for degradation byproteasomeInhibitor of MDM2-p53interactions is nutlinMDM2 also interacts withubiquitin protease, USP7that reversesubiquitylation to preventdegradation withproteasomeFine regulatory circuit
  7. 7. JalView
  8. 8. Mdm2 [Homo sapiens] FASTA>gi|155183770|gb|ABT17086.1| Mdm2 [Homo sapiens]MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSE
  9. 9. ClustalW2
  10. 10. HomoloGeneHomologs werediscovered in thesevertebrates:Chimpanzee, Rhesusmacaque, Dog,Cattle, House mouse,Brown rat, RedJunglefowl, Zebrafish
  11. 11. ReferencesHarris. Curtis C. et. al. Proceedings of the National Academy of Sciences.http://www.pnas.org/content/103/6/1659/F1.expansion.html. Accessed May7th2013.Proteasome. Wikipedia. http://en.wikipedia.org/wiki/Proteasome. AccessedMay 7th2013Mdm2. Wikipedia. http://en.wikipedia.org/wiki/Mdm2. Accessed May 7th2013.Knappskog et. al. MDM2 promoter SNP285 and SNP309; phylogeny andimpact on cancer risk. PubMed Central.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260817/. Accessed May 13th2013Jayaraman A et. al. The interaction of p53 and MDM2 genes in cancers, insilico studies and phylogenetic analysis. Biology and Medicine Vol 3 (3): 01-12, 2011.Databases/Tools Used: NCBI Protein. NCBI BLASTp. ClustalW2.ClustalW2 Phylogeny. Cn3D. HomoloGene.

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