Mdm2Negative regulator of p53 tumor suppressorgeneDiscovery from transformed mouse cell lineMdm2 over expression with Ras oncogene ledto tumor formation in nude miceHuman homolog is sometimes called Hdm2
Mdm2Increased levels ofmdm2 found in:Soft tissue sarcomasOsteosarcomasBreast tumors
E3 ligase activityTargets both itself and p53for degradation byproteasomeInhibitor of MDM2-p53interactions is nutlinMDM2 also interacts withubiquitin protease, USP7that reversesubiquitylation to preventdegradation withproteasomeFine regulatory circuit
HomoloGeneHomologs werediscovered in thesevertebrates:Chimpanzee, Rhesusmacaque, Dog,Cattle, House mouse,Brown rat, RedJunglefowl, Zebrafish
ReferencesHarris. Curtis C. et. al. Proceedings of the National Academy of Sciences.http://www.pnas.org/content/103/6/1659/F1.expansion.html. Accessed May7th2013.Proteasome. Wikipedia. http://en.wikipedia.org/wiki/Proteasome. AccessedMay 7th2013Mdm2. Wikipedia. http://en.wikipedia.org/wiki/Mdm2. Accessed May 7th2013.Knappskog et. al. MDM2 promoter SNP285 and SNP309; phylogeny andimpact on cancer risk. PubMed Central.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260817/. Accessed May 13th2013Jayaraman A et. al. The interaction of p53 and MDM2 genes in cancers, insilico studies and phylogenetic analysis. Biology and Medicine Vol 3 (3): 01-12, 2011.Databases/Tools Used: NCBI Protein. NCBI BLASTp. ClustalW2.ClustalW2 Phylogeny. Cn3D. HomoloGene.